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Protein

General transcription factor IIH subunit 4

Gene

SPRG_13048

Organism
Saprolegnia parasitica (strain CBS 223.65)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
ORF Names:SPRG_13048Imported
OrganismiSaprolegnia parasitica (strain CBS 223.65)Imported
Taxonomic identifieri695850 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesOomycetesSaprolegnialesSaprolegniaceaeSaprolegnia
Proteomesi
  • UP000030745 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SPRG_13048

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144
OMAiFLKTHTH

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A067BTA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQSLESFHQ AATVPKGPSE AGGASASHLS IIVETNFKVY AYTSSSLHIA
60 70 80 90 100
MLSVFVDIVV RLKNMAVGFL TRESIRSALI HGISAEQIYD FLMQHAHPKM
110 120 130 140 150
VQNTPVIPEN IADQLYLWQR ERNRIQFVPG ELLEGFTLSE EFAAVVLYAR
160 170 180
DLDVLTWSDA SQHKLTVAQH GADAVRKYIQ SLRG
Length:184
Mass (Da):20,511
Last modified:September 3, 2014 - v1
Checksum:i0EC528095E1C0CEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KK583282 Genomic DNA Translation: KDO21709.1
RefSeqiXP_012207630.1, XM_012352240.1

Genome annotation databases

EnsemblProtistsiKDO21709; KDO21709; SPRG_13048
GeneIDi24134955
KEGGispar:SPRG_13048

Entry informationi

Entry nameiA0A067BTA1_SAPPC
AccessioniPrimary (citable) accession number: A0A067BTA1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: February 28, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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