Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UvrABC system protein B

Gene

uvrB

Organism
Streptococcus pneumoniae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nucleaseUniRule annotationSAAS annotation, HelicaseImported, Hydrolase
Biological processDNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotationSAAS annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotationImported
Synonyms:uvrB_1Imported, uvrB_2Imported, uvrB_3Imported
ORF Names:AWW74_10375Imported, AZJ08_04145Imported, AZJ10_00430Imported, AZJ11_08790Imported, AZJ13_05165Imported, AZJ14_05325Imported, AZJ15_09675Imported, AZJ17_09025Imported, AZJ19_05185Imported, AZJ20_07075Imported, AZJ80_04535Imported, AZK24_06195Imported, C4N11_05835Imported, CHL72_02980Imported, ERS019260_00707Imported, ERS019367_01221Imported, ERS019416_00440Imported, ERS020178_03752Imported, ERS020835_00402Imported, ERS021189_03816Imported, ERS021218_00529Imported, ERS021300_01825Imported, ERS021360_00307Imported, ERS021634_05386Imported, ERS021762_00047Imported, ERS022045_04735Imported, ERS022363_00296Imported, ERS022390_00246Imported, ERS043879_00913Imported, ERS232471_01604Imported, ERS232499_01087Imported, ERS367337_01939Imported, ERS409064_01233Imported, NTPn46_01315Imported, SAMEA1026615_00803Imported, SpnNT_01070Imported
OrganismiStreptococcus pneumoniaeImported
Taxonomic identifieri1313 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000234783 Componenti: Unassembled WGS sequence
  • UP000234866 Componenti: Unassembled WGS sequence
  • UP000039962 Componenti: Unassembled WGS sequence
  • UP000045067 Componenti: Unassembled WGS sequence
  • UP000075530 Componenti: Unassembled WGS sequence
  • UP000234916 Componenti: Unassembled WGS sequence
  • UP000235048 Componenti: Unassembled WGS sequence
  • UP000234900 Componenti: Unassembled WGS sequence
  • UP000042505 Componenti: Unassembled WGS sequence
  • UP000234890 Componenti: Unassembled WGS sequence
  • UP000234762 Componenti: Unassembled WGS sequence
  • UP000044228 Componenti: Unassembled WGS sequence
  • UP000039440 Componenti: Unassembled WGS sequence
  • UP000235003 Componenti: Unassembled WGS sequence
  • UP000234868 Componenti: Unassembled WGS sequence
  • UP000043857 Componenti: Unassembled WGS sequence
  • UP000216248 Componenti: Unassembled WGS sequence
  • UP000074995 Componenti: Unassembled WGS sequence
  • UP000238028 Componenti: Chromosome
  • UP000046356 Componenti: Unassembled WGS sequence
  • UP000031393 Componenti: Chromosome
  • UP000071227 Componenti: Unassembled WGS sequence
  • UP000070671 Componenti: Unassembled WGS sequence
  • UP000042781 Componenti: Unassembled WGS sequence
  • UP000044493 Componenti: Unassembled WGS sequence
  • UP000235012 Componenti: Unassembled WGS sequence
  • UP000198094 Componenti: Unassembled WGS sequence
  • UP000045409 Componenti: Unassembled WGS sequence
  • UP000044692 Componenti: Unassembled WGS sequence
  • UP000039362 Componenti: Unassembled WGS sequence
  • UP000043492 Componenti: Unassembled WGS sequence
  • UP000046095 Componenti: Unassembled WGS sequence
  • UP000234831 Componenti: Unassembled WGS sequence
  • UP000042569 Componenti: Unassembled WGS sequence
  • UP000044899 Componenti: Unassembled WGS sequence
  • UP000044836 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 188Helicase ATP-bindingInterPro annotationAdd BLAST158
Domaini435 – 601Helicase C-terminalInterPro annotationAdd BLAST167
Domaini626 – 661UVRInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili269 – 289Sequence analysisAdd BLAST21
Coiled coili622 – 649Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 120Beta-hairpinUniRule annotationAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CCW Bacteria
COG0556 LUCA

Family and domain databases

CDDicd00079 HELICc, 1 hit
HAMAPiMF_00204 UvrB, 1 hit
InterProiView protein in InterPro
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
IPR036876 UVR_dom_sf
IPR004807 UvrB
IPR024759 UvrB_YAD/RRR_dom
PANTHERiPTHR24029 PTHR24029, 1 hit
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF04851 ResIII, 1 hit
PF02151 UVR, 1 hit
PF12344 UvrB, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF46600 SSF46600, 1 hit
SSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00631 uvrb, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

A0A064C029-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINHITDNQF KLVSKYQPSG DQPQAIEQLV DNIEGGEKAQ ILMGATGTGK
60 70 80 90 100
TYTMSQVISK VNKPTLVIAH NKTLAGQLYG EFKEFFPENA VEYFVSYYDY
110 120 130 140 150
YQPEAYVPSS DTYIEKDSSV NDEIDKLRHS ATSALLERND VIVVASVSCI
160 170 180 190 200
YGLGSPKEYA DSVVSLRPGL EISRDKLLND LVDIQFERND IDFQRGRFRV
210 220 230 240 250
RGDVVEIFPA SRDEHAFRVE FFGDEIDRIR EVEALTGQVL GEVDHLAIFP
260 270 280 290 300
ATHFVTNDDH MEVAIAKIQA ELEEQLAVFE KEGKLLEAQR LKQRTEYDIE
310 320 330 340 350
MLREMGYTNG VENYSRHMDG RSEGEPPYTL LDFFPDDFLI MIDESHMTIG
360 370 380 390 400
QIKGMYNGDR SRKEMLVNYG FRLPSALDNR PLRREEFESH VHQIVYVSAT
410 420 430 440 450
PGDYENEQTE TVIEQIIRPT GLLDPEVEVR PTMGQIDDLL GEINARVEKN
460 470 480 490 500
ERTFITTLTK KMAEDLTDYF KEMGIKVKYM HSDIKTLERT EIIRDLRLGV
510 520 530 540 550
FDVLVGINLL REGIDVPEVS LVAILDADKE GFLRNERGLI QTIGRAARNS
560 570 580 590 600
EGHVIMYADT VTQSMQRAID ETARRRKIQM AYNEEHGIVP QTIKKEIRDL
610 620 630 640 650
IAVTKAVAKE EDKEVDINSL NKQERKELVK KLEKQMQEAV EVLDFELAAQ
660
IRDMMLEVKA LD
Length:662
Mass (Da):75,734
Last modified:September 3, 2014 - v1
Checksum:iC2EB617ED537BDD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP007593 Genomic DNA Translation: AJD72009.1
CP026670 Genomic DNA Translation: AVD75074.1
CKCQ01000009 Genomic DNA Translation: CIP97426.1
CKOI01000004 Genomic DNA Translation: CIX00195.1
CKRO01000014 Genomic DNA Translation: CIZ03724.1
CKTJ01000003 Genomic DNA Translation: CIZ81409.1
CLAY01000004 Genomic DNA Translation: CJE89531.1
CLBL01000027 Genomic DNA Translation: CJF68922.1
CLFU01000049 Genomic DNA Translation: CJJ79047.1
CLJU01000046 Genomic DNA Translation: CJM06229.1
CMAP01000002 Genomic DNA Translation: CJV09751.1
CMBJ01000006 Genomic DNA Translation: CJV63805.1
CMJQ01000001 Genomic DNA Translation: CKA62733.1
CMOR01000026 Genomic DNA Translation: CKE28549.1
CMQD01000015 Genomic DNA Translation: CKE89273.1
CQZO01000017 Genomic DNA Translation: COD53196.1
CRTN01000029 Genomic DNA Translation: COR38720.1
CRVC01000004 Genomic DNA Translation: COR39860.1
CNOG02000129 Genomic DNA Translation: CTO25792.1
FDEX01000008 Genomic DNA Translation: CVT08300.1
FEBA01000019 Genomic DNA Translation: CWE86993.1
LRSN01000134 Genomic DNA Translation: KWX83099.1
LJWP01000037 Genomic DNA Translation: KXW43671.1
NOIM01000130 Genomic DNA Translation: OZS33071.1
LTCG01000241 Genomic DNA Translation: PLV66179.1
LTCI01000023 Genomic DNA Translation: PLV72743.1
LTCJ01000175 Genomic DNA Translation: PLV73417.1
LTCL01000177 Genomic DNA Translation: PLV75121.1
LTCO01000115 Genomic DNA Translation: PLV82150.1
LTCQ01000285 Genomic DNA Translation: PLV84479.1
LTCP01000165 Genomic DNA Translation: PLV85132.1
LTCR01000146 Genomic DNA Translation: PLV85280.1
LTCT01000137 Genomic DNA Translation: PLV93711.1
LTCV01000178 Genomic DNA Translation: PLV96034.1
LTCU01000192 Genomic DNA Translation: PLV96237.1
FYQS01000006 Genomic DNA Translation: SNI81745.1
RefSeqiWP_000607027.1, NZ_PEKA01000021.1

Genome annotation databases

EnsemblBacteriaiAJD72009; AJD72009; SpnNT_01070
CEW67834; CEW67834; ERS021528_00389
CFP91348; CFP91348; ERS013931_00983
CIP97426; CIP97426; ERS019260_00707
CIT80466; CIT80466; ERS019595_00798
CIX00195; CIX00195; ERS019416_00440
CIZ03724; CIZ03724; ERS019367_01221
CIZ81409; CIZ81409; ERS021360_00307
CJE89531; CJE89531; ERS020835_00402
CJF68922; CJF68922; ERS021300_01825
CJJ79047; CJJ79047; ERS021634_05386
CJK50723; CJK50723; ERS022016_01704
CJM06229; CJM06229; ERS022045_04735
CJV09751; CJV09751; ERS022390_00246
CJV63805; CJV63805; ERS022363_00296
CJY48501; CJY48501; ERS022329_01484
CKA62733; CKA62733; ERS021762_00047
CKE28549; CKE28549; ERS232471_01604
CKE89273; CKE89273; ERS232499_01087
CMX09837; CMX09837; ERS077238_01558
CNA89347; CNA89347; ERS077235_01737
CNB11305; CNB11305; ERS077244_01635
CNY97600; CNY97600; ERS020873_00678
COD53196; COD53196; ERS020178_03752
COR38720; COR38720; ERS021189_03816
COR39860; COR39860; ERS021218_00529
CTE04215; CTE04215; ERS044129_00912
CTO25792; CTO25792; ERS043879_00913
CVM60221; CVM60221; ERS367628_00852
CVO65986; CVO65986; ERS367764_00217
CVO89808; CVO89808; ERS408893_01785
CVQ15436; CVQ15436; ERS515225_00617
CVT08300; CVT08300; ERS409064_01233
CVY82093; CVY82093; ERS409372_00798
CWE86993; CWE86993; ERS367337_01939
CWM26056; CWM26056; ERS515182_01406
CYI54601; CYI54601; ERS394170_00264
KWX83099; KWX83099; AWW74_10375
KXW43671; KXW43671; NTPn46_01315
PATRICifig|1313.5270.peg.10

Similar proteinsi

Entry informationi

Entry nameiA0A064C029_STREE
AccessioniPrimary (citable) accession number: A0A064C029
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: July 18, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health