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Protein

DNA ligase

Gene

lig

Organism
Methanoculleus sp. MH98A
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei244ATPUniRule annotation1
Active sitei246N6-AMP-lysine intermediateUniRule annotation1
Binding sitei251ATPUniRule annotation1
Binding sitei266ATPUniRule annotation1
Binding sitei295ATPUniRule annotation1
Binding sitei334ATPUniRule annotation1
Binding sitei405ATPUniRule annotation1
Binding sitei411ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
ORF Names:EI28_11045Imported
OrganismiMethanoculleus sp. MH98AImported
Taxonomic identifieri1495314 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanomicrobiaceaeMethanoculleus
Proteomesi
  • UP000027172 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini333 – 446DNA_LIGASE_A3InterPro annotationAdd BLAST114

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A063ZE17-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQFLEFARVC ERLEGIPGRL DMIEQVAAVL PRLDDGELPV FVRFVMGRVF
60 70 80 90 100
PDWSTKKLGV GPNLLYDAVA YVVGTKRETV REAINTTGDV GLAVEGLLAK
110 120 130 140 150
KEQTSFFIKE LDLTDVYREF ERMAAAEGQR SQREKLRVAE GLFGNARPLE
160 170 180 190 200
GRYLARLMLE ELRIGMGEGN VRDAVAKAFE VDVRLVEHAH QALNDLGEVA
210 220 230 240 250
LLARRDPDAL SRVTIEPFRP VKMMLAQAGT IAAQIEDHGE VAVEYKYDGS
260 270 280 290 300
RFQFHKVGGV CRIYSRKLED VTGSLPDIAN LLLEATDHDV ILDGEAVAVR
310 320 330 340 350
DGKPMPFQYV IRRFRRKHEV DSMMEQIELV PRVFDILYLD GETLMDRPLA
360 370 380 390 400
ERRKALDEVL RAHVAPQFPA TDAAAAEAIY AEALNLGHEG VMVKVLDSPY
410 420 430 440 450
TPGVRGRLWV KVKPGVETLD LAVVGAEWGE GRRAGTFGSF LLAVQDQGRL
460 470 480 490 500
LPVGKVATGI TDEVLADLYA LFKDRVIARS GKEVTLEPEV VFEVGYSEIQ
510 520 530 540
TSPNYESGYA LRFPRFVRVR EDKSVDEVET LDTLVERYAR QKNGLGSL
Length:548
Mass (Da):61,176
Last modified:September 3, 2014 - v1
Checksum:i2B5A4DCC5C4DC941
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JMIO01000067 Genomic DNA Translation: KDE54867.1
RefSeqiWP_048114359.1, NZ_JMIO01000067.1

Genome annotation databases

EnsemblBacteriaiKDE54867; KDE54867; EI28_11045

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JMIO01000067 Genomic DNA Translation: KDE54867.1
RefSeqiWP_048114359.1, NZ_JMIO01000067.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKDE54867; KDE54867; EI28_11045

Phylogenomic databases

OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A063ZE17_9EURY
AccessioniPrimary (citable) accession number: A0A063ZE17
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: March 28, 2018
This is version 18 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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