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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bacillus subtilis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotationSAAS annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei425UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotationSAAS annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00181

UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
ORF Names:B4122_3374Imported, B4417_2936Imported, C0W65_04025Imported, HS3_02447Imported, SC09_contig4orf00055Imported
OrganismiBacillus subtilisImported
Taxonomic identifieri1423 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000249704 Componenti: Unassembled WGS sequence
  • UP000076589 Componenti: Unassembled WGS sequence
  • UP000032247 Componenti: Unassembled WGS sequence
  • UP000076442 Componenti: Unassembled WGS sequence
  • UP000236279 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphothreonineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 2 hits
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A063X6V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTHVRFDYSK ALTFFNEHEL TYLRDFVKTA HHNIHEKTGA GSDFLGWVDL
60 70 80 90 100
PEHYDKEEFA RIKKSAEKIK SDSDVLLVVG IGGSYLGARA AIEALNHAFY
110 120 130 140 150
NTLPKAKRGN PQVIFIGNNI SSSYMRDVMD LLEDVDFSIN VISKSGTTTE
160 170 180 190 200
PAIAFRIFRK LLEEKYGKEE AKARIYATTD KERGALKTLS NEEGFESFVI
210 220 230 240 250
PDDVGGRYSV LTAVGLLPIA VSGVNIDDMM KGALDASKDF ATSELEDNPA
260 270 280 290 300
YQYAVVRNVL YNKGKTIEML INYEPALQYF AEWWKQLFGE SEGKDEKGIY
310 320 330 340 350
PSSANYSTDL HSLGQYVQEG RRDLFETVLN VEKPKHELTI EEADNDLDGL
360 370 380 390 400
NYLAGKTVDF VNKKAFQGTM LAHTDGNVPN LIVNIPELNA YTFGYLVYFF
410 420 430 440 450
EKACAMSGYL LGVNPFDQPG VEAYKVNMFA LLGKPGFEEK KAELEKRLED
Length:450
Mass (Da):50,543
Last modified:September 3, 2014 - v1
Checksum:iDAAA87AFB81E1DA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025941 Genomic DNA Translation: AUS11258.1
JXBC01000013 Genomic DNA Translation: KIU05314.1
LJSM01000042 Genomic DNA Translation: KZD78147.1
LJZV01000016 Genomic DNA Translation: KZD90453.1
QJJA01000002 Genomic DNA Translation: RAP08505.1
RefSeqiWP_003243401.1, NZ_QJJA01000002.1

Genome annotation databases

EnsemblBacteriaiAOL98991; AOL98991; BS16045_03301
KIU05314; KIU05314; SC09_contig4orf00055
KZD78147; KZD78147; B4417_2936
KZD90453; KZD90453; B4122_3374
PATRICifig|1423.134.peg.2215

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025941 Genomic DNA Translation: AUS11258.1
JXBC01000013 Genomic DNA Translation: KIU05314.1
LJSM01000042 Genomic DNA Translation: KZD78147.1
LJZV01000016 Genomic DNA Translation: KZD90453.1
QJJA01000002 Genomic DNA Translation: RAP08505.1
RefSeqiWP_003243401.1, NZ_QJJA01000002.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAOL98991; AOL98991; BS16045_03301
KIU05314; KIU05314; SC09_contig4orf00055
KZD78147; KZD78147; B4417_2936
KZD90453; KZD90453; B4122_3374
PATRICifig|1423.134.peg.2215

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00181

UPA00138

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 2 hits
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A063X6V5_BACIU
AccessioniPrimary (citable) accession number: A0A063X6V5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: November 7, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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