Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 41 (02 Jun 2021)
Sequence version 1 (03 Sep 2014)
Previous versions | rss
Add a publicationFeedback
Protein

Bifunctional ligase/repressor BirA

Gene

birA

Organism
Bacillus cereus
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei118BiotinUniRule annotation1
Binding sitei189BiotinUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi23 – 42H-T-H motifUniRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, LigaseUniRule annotationImported, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotation
LigandATP-bindingUniRule annotation, BiotinUniRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional ligase/repressor BirAUniRule annotation
Alternative name(s):
Biotin--[acetyl-CoA-carboxylase] ligaseUniRule annotation (EC:6.3.4.15UniRule annotation)
Biotin--protein ligaseUniRule annotation
Biotin-[acetyl-CoA carboxylase] synthetaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:birAUniRule annotationImported
ORF Names:AT274_00330Imported, B2J90_08220Imported, BcrFT9_01307Imported, BG03_3596Imported, CEW46_00635Imported, CON22_06590Imported, HPG46_07250Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus cereusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1396 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000075591 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000503196 Componenti: Chromosome
  • UP000231827 Componenti: Unassembled WGS sequence
  • UP000031911 Componenti: Chromosome
  • UP000027990 Componenti: Chromosome
  • UP000220268 Componenti: Unassembled WGS sequence
  • UP000193458 Componenti: Chromosome

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 262BPL/LPL catalyticInterPro annotationAdd BLAST192

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 124Biotin bindingUniRule annotation3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the biotin--protein ligase family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16442, BPL, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00978, Bifunct_BirA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030855, Bifunct_BirA
IPR004408, Biotin_CoA_COase_ligase
IPR003142, BPL_C
IPR004143, BPL_LPL_catalytic
IPR013196, HTH_11
IPR008988, Transcriptional_repressor_C
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02237, BPL_C, 1 hit
PF03099, BPL_LplA_LipB, 1 hit
PF08279, HTH_11, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 1 hit
SSF50037, SSF50037, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00121, birA_ligase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51733, BPL_LPL_CATALYTIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A063CSD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSTIRKQLL QVFSEADGEF VSGQTISDKL GCSRTAVWKH MEDLRNEGYE
60 70 80 90 100
LEAVRRLGYR IASKPDKVTA NEIQLGLQTK HIGRTVYFEE SVESTQHIAA
110 120 130 140 150
KLAYEGAEEG TIVVAEEQTA GRGRLSRKWH SPKGTGIWMS IILRPSIPVH
160 170 180 190 200
HAPQLTLLAA VSVAQAIEKC TGVNVGIKWP NDILIQGKKA VGILTEMQAD
210 220 230 240 250
PDKINAVIMG IGINANQKQE HFDEEIQHIA TSLAIESGKP IVRAELMQQI
260 270 280 290 300
FLQLEKLYEE YLQNGFSVIK ILWESYAVSI GKEINARTMR ETITGVAKGI
310 320
TEDGVLLLED HEGKVHHIHS ADIEIK
Length:326
Mass (Da):36,235
Last modified:September 3, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA0901872A4779CB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP008712 Genomic DNA Translation: AIE78851.1
CP009369 Genomic DNA Translation: AJG93920.1
CP020937 Genomic DNA Translation: ARO17473.1
LOMT01000068 Genomic DNA Translation: KXX98448.1
NVMO01000007 Genomic DNA Translation: PEF47199.1
NJNO01000001 Genomic DNA Translation: PJZ23642.1
CP053656 Genomic DNA Translation: QKE06679.1

NCBI Reference Sequences

More...
RefSeqi
WP_001192043.1, NZ_VVXM01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AJG93920; AJG93920; BG03_3596
ARO17473; ARO17473; B2J90_08220
KXX98448; KXX98448; AT274_00330
PEF47199; PEF47199; CON22_06590
PJZ23642; PJZ23642; CEW46_00635

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45021532
56651392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bcef:BcrFT9_01307

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1396.419.peg.44

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP008712 Genomic DNA Translation: AIE78851.1
CP009369 Genomic DNA Translation: AJG93920.1
CP020937 Genomic DNA Translation: ARO17473.1
LOMT01000068 Genomic DNA Translation: KXX98448.1
NVMO01000007 Genomic DNA Translation: PEF47199.1
NJNO01000001 Genomic DNA Translation: PJZ23642.1
CP053656 Genomic DNA Translation: QKE06679.1
RefSeqiWP_001192043.1, NZ_VVXM01000008.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAJG93920; AJG93920; BG03_3596
ARO17473; ARO17473; B2J90_08220
KXX98448; KXX98448; AT274_00330
PEF47199; PEF47199; CON22_06590
PJZ23642; PJZ23642; CEW46_00635
GeneIDi45021532
56651392
KEGGibcef:BcrFT9_01307
PATRICifig|1396.419.peg.44

Family and domain databases

CDDicd16442, BPL, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00978, Bifunct_BirA, 1 hit
InterProiView protein in InterPro
IPR030855, Bifunct_BirA
IPR004408, Biotin_CoA_COase_ligase
IPR003142, BPL_C
IPR004143, BPL_LPL_catalytic
IPR013196, HTH_11
IPR008988, Transcriptional_repressor_C
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PfamiView protein in Pfam
PF02237, BPL_C, 1 hit
PF03099, BPL_LplA_LipB, 1 hit
PF08279, HTH_11, 1 hit
SUPFAMiSSF46785, SSF46785, 1 hit
SSF50037, SSF50037, 1 hit
TIGRFAMsiTIGR00121, birA_ligase, 1 hit
PROSITEiView protein in PROSITE
PS51733, BPL_LPL_CATALYTIC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A063CSD4_BACCE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A063CSD4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: June 2, 2021
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again