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Entry version 57 (13 Nov 2019)
Sequence version 1 (03 Sep 2014)
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Protein

Pyruvate dehydrogenase E1 component

Gene

aceE_1

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi260MagnesiumUniRule annotation1
Metal bindingi290MagnesiumUniRule annotation1
Metal bindingi292Magnesium; via carbonyl oxygenUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation, PyruvateUniRule annotationImported, Thiamine pyrophosphateUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aceE_1Imported
Synonyms:aceEImported, aceE_2Imported
ORF Names:DSI35_30220Imported, ERS023446_01407Imported, ERS024213_00469Imported, ERS027651_00110Imported, ERS124361_03142Imported, EZX46_16110Imported, FDK60_17345Imported, SAMEA2682835_04576Imported, SAMEA2682864_00429Imported, SAMEA2683035_01253Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000183655 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256252 Componenti: Unassembled WGS sequence
  • UP000298273 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000305204 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000298647 Componenti: Unassembled WGS sequence
  • UP000049139 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

SAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini165 – 331TRANSKETOLASE_1InterPro annotationAdd BLAST167
Domaini506 – 733PDH_E1_MInterPro annotationAdd BLAST228

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20PolarSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105DAQ Bacteria
COG2609 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02017 TPP_E1_EcPDC_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.920, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035807 PDC_E1_N
IPR004660 PDH_E1
IPR041621 PDH_E1_M
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N

The PANTHER Classification System

More...
PANTHERi
PTHR43825:SF3 PTHR43825:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17831 PDH_E1_M, 1 hit
PF00456 Transketolase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000156 Pyruvate_dh_E1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00759 aceE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A062WIC9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTDFARHDL AQNSNSASEP DRVRVIREGV ASYLPDIDPE ETSEWLESFD
60 70 80 90 100
TLLQRCGPSR ARYLMLRLLE RAGEQRVAIP ALTSTDYVNT IPTELEPWFP
110 120 130 140 150
GDEDVERRYR AWIRWNAAIM VHRAQRPGVG VGGHISTYAS SAALYEVGFN
160 170 180 190 200
HFFRGKSHPG GGDQVFIQGH ASPGIYARAF LEGRLTAEQL DGFRQEHSHV
210 220 230 240 250
GGGLPSYPHP RLMPDFWEFP TVSMGLGPLN AIYQARFNHY LHDRGIKDTS
260 270 280 290 300
DQHVWCFLGD GEMDEPESRG LAHVGALEGL DNLTFVINCN LQRLDGPVRG
310 320 330 340 350
NGKIIQELES FFRGAGWNVI KVVWGREWDA LLHADRDGAL VNLMNTTPDG
360 370 380 390 400
DYQTYKANDG GYVRDHFFGR DPRTKALVEN MSDQDIWNLK RGGHDYRKVY
410 420 430 440 450
AAYRAAVDHK GQPTVILAKT IKGYALGKHF EGRNATHQMK KLTLEDLKEF
460 470 480 490 500
RDTQRIPVSD AQLEENPYLP PYYHPGLNAP EIRYMLDRRR ALGGFVPERR
510 520 530 540 550
TKSKALTLPG RDIYAPLKKG SGHQEVATTM ATVRTFKEVL RDKQIGPRIV
560 570 580 590 600
PIIPDEARTF GMDSWFPSLK IYNRNGQLYT AVDADLMLAY KESEVGQILH
610 620 630 640 650
EGINEAGSVG SFIAAGTSYA THNEPMIPIY IFYSMFGFQR TGDSFWAAAD
660 670 680 690 700
QMARGFVLGA TAGRTTLTGE GLQHADGHSL LLAATNPAVV AYDPAFAYEI
710 720 730 740 750
AYIVESGLAR MCGENPENIF FYITVYNEPY VQPPEPENFD PEGVLRGIYR
760 770 780 790 800
YHAATEQRTN KAQILASGVA MPAALRAAQM LAAEWDVAAD VWSVTSWGEL
810 820 830 840 850
NRDGVAIETE KLRHPDRPAG VPYVTRALEN ARGPVIAVSD WMRAVPEQIR
860 870 880 890 900
PWVPGTYLTL GTDGFGFSDT RPAARRYFNT DAESQVVAVL EALAGDGEID
910 920 930
PSVPVAAARQ YRIDDVAAAP EQTTDPGPGA
Length:930
Mass (Da):103,440
Last modified:September 3, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6542FF8373756D53
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CNDE01000068 Genomic DNA Translation: CKO44676.1
CIEA01000001 Genomic DNA Translation: CKR37379.1
CHDS01000068 Genomic DNA Translation: CNH21735.1
CQGE01000022 Genomic DNA Translation: CNM84150.1
QSXG01002195 Genomic DNA Translation: REM95272.1
FPPU01000022 Genomic DNA Translation: SGD64757.1
FPTZ01000006 Genomic DNA Translation: SGH48534.1
FPXX01000002 Genomic DNA Translation: SGL45286.1
SMOE01000097 Genomic DNA Translation: TFB18998.1
SZTS01000068 Genomic DNA Translation: TKR37460.1

NCBI Reference Sequences

More...
RefSeqi
WP_003911788.1, NZ_VOVY01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC46670; AMC46670; RN05_2394
CKO44676; CKO44676; ERS024213_00469
CNH21735; CNH21735; ERS124361_03142
CNM84150; CNM84150; ERS023446_01407
CNY46681; CNY46681; ERS013471_01679
CRH09775; CRH09775; BN1303_00330

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.1654

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CNDE01000068 Genomic DNA Translation: CKO44676.1
CIEA01000001 Genomic DNA Translation: CKR37379.1
CHDS01000068 Genomic DNA Translation: CNH21735.1
CQGE01000022 Genomic DNA Translation: CNM84150.1
QSXG01002195 Genomic DNA Translation: REM95272.1
FPPU01000022 Genomic DNA Translation: SGD64757.1
FPTZ01000006 Genomic DNA Translation: SGH48534.1
FPXX01000002 Genomic DNA Translation: SGL45286.1
SMOE01000097 Genomic DNA Translation: TFB18998.1
SZTS01000068 Genomic DNA Translation: TKR37460.1
RefSeqiWP_003911788.1, NZ_VOVY01000005.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC46670; AMC46670; RN05_2394
CKO44676; CKO44676; ERS024213_00469
CNH21735; CNH21735; ERS124361_03142
CNM84150; CNM84150; ERS023446_01407
CNY46681; CNY46681; ERS013471_01679
CRH09775; CRH09775; BN1303_00330
PATRICifig|1773.206.peg.1654

Phylogenomic databases

eggNOGiENOG4105DAQ Bacteria
COG2609 LUCA

Family and domain databases

CDDicd02017 TPP_E1_EcPDC_like, 1 hit
Gene3Di3.40.50.920, 1 hit
InterProiView protein in InterPro
IPR035807 PDC_E1_N
IPR004660 PDH_E1
IPR041621 PDH_E1_M
IPR029061 THDP-binding
IPR009014 Transketo_C/PFOR_II
IPR005474 Transketolase_N
PANTHERiPTHR43825:SF3 PTHR43825:SF3, 1 hit
PfamiView protein in Pfam
PF17831 PDH_E1_M, 1 hit
PF00456 Transketolase_N, 1 hit
PIRSFiPIRSF000156 Pyruvate_dh_E1, 1 hit
SUPFAMiSSF52518 SSF52518, 2 hits
SSF52922 SSF52922, 1 hit
TIGRFAMsiTIGR00759 aceE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A062WIC9_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A062WIC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: November 13, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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