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Entry version 36 (02 Jun 2021)
Sequence version 1 (03 Sep 2014)
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Protein
Submitted name:

Ras GTPase-activating protein nGAP-like protein

Gene

H671_5g15045

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ras GTPase-activating protein nGAP-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:H671_5g15045Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000030759 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini244 – 474PHInterPro annotationAdd BLAST231
Domaini643 – 835Ras-GAPInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni231 – 252DisorderedSequence analysisAdd BLAST22
Regioni282 – 403DisorderedSequence analysisAdd BLAST122
Regioni1065 – 1270DisorderedSequence analysisAdd BLAST206
Regioni1287 – 1311DisorderedSequence analysisAdd BLAST25
Regioni1473 – 1496DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1350 – 1409Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi330 – 354Polar residuesSequence analysisAdd BLAST25
Compositional biasi388 – 403Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1089 – 1150Polar residuesSequence analysisAdd BLAST62
Compositional biasi1151 – 1170Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1227 – 1269Polar residuesSequence analysisAdd BLAST43
Compositional biasi1294 – 1311Basic and acidic residuesSequence analysisAdd BLAST18

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR021887, DUF3498
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot

The PANTHER Classification System

More...
PANTHERi
PTHR10194, PTHR10194, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF12004, DUF3498, 1 hit
PF00616, RasGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A061HYI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSPSSGGA AEALSWPEMF SGLESDSPLP PEDLDAVVPV SGAVAGGMLD
60 70 80 90 100
RILLESVCQQ QSWVRVYGFS VDMKFYFSGL VYFCHINVVD NVLYHKESYG
110 120 130 140 150
RSLSEPAYAN SEIGASLKMY PWCGSFKSQR KKNECAVSKL EKPLEAYRWQ
160 170 180 190 200
KQPGFRKKGS KMERLQTNNG DLDEPQQKVL PETVGTNASS SAHEIPETST
210 220 230 240 250
EKLNLHNAQS LRAPFTSGFS RMLSLKGEAT NEPVEEDVKG PPTHRLSCGQ
260 270 280 290 300
SPYTETTSWE RKYCILTDSQ LVLLNKEKEI PVEGQEQQTD STKGRCLRRT
310 320 330 340 350
VSVPSEGQFP EYPPEGTAKL EVPAERSPRR RSISGTSTSE KPNSMDTANT
360 370 380 390 400
SPFKVPGFFS KRLKGSIKRT KSQSKLDRNT SFRLPSLRSA DDRSRGLPKL
410 420 430 440 450
KESRSHESLL SPCSAVECLD LGRGEPVSVK PLHSSILGQD FCFEVTYLSG
460 470 480 490 500
SKCFSCNSAS ERDKWMENLR RTVQPNKDNC RRAENVLRLW IIEAKDLAPK
510 520 530 540 550
KKYFCELCLD DTLFARTTSK TKADNIFWGE HFEFYSLPHL HSITVHIYKD
560 570 580 590 600
VEKKKKKDKN NYVGLVNIPT ASVTGRQFVE KWYPVSTPTP NKGKTGGPSI
610 620 630 640 650
RIKSRFQTIT ILPMEQYKEF AEFITSNYTM LCSVLEPVIS VRNKEELACA
660 670 680 690 700
LVHILQSTGR AKDFLTDLVM SEVDRCGEHD VLIFRENTIA TKSIEEYLKL
710 720 730 740 750
VGQQYLHDAL GEFIKALYES DENCEVDPSK CSSSELIDHQ SNLKMCCELA
760 770 780 790 800
FCKIINSYCV FPRELKEVFA SWKQQCLNRG KQDISERLIS ASLFLRFLCP
810 820 830 840 850
AIMSPSLFSL MQEYPDDRTS RTLTLIAKVI QNLANFAKFG NKEEYMAFMN
860 870 880 890 900
DFLEHEWGGM KRFLLEISNP DTISNTPGFD GYIDLGRELS VLHSLLWEVV
910 920 930 940 950
SQLDKGENSF LQATVAKLGP LPRVLADITK SLSNPTPIQQ QLRRFAEHSS
960 970 980 990 1000
SPNVSGSLSS GLQKIFEDPT DSDLHKLKSP SQENTDGYFR GKTLLLVQQA
1010 1020 1030 1040 1050
SSQSMTYSEK DEKENSLPNG RSISLMDLQD THAAQVEHAS VMLDVPMRLA
1060 1070 1080 1090 1100
GSQLSITQVA SIKQLRETQS TPQSAPQVRR PLHPALNQPG SLQPLSFQNP
1110 1120 1130 1140 1150
VYHLNNPVPT MPKASVDSSL ENLSTASSRS QSNSEDFKLS GPSNSSMEDF
1160 1170 1180 1190 1200
TKRSTHSEDY SRRHTVPDRH IPLALPRQNS TGQSQIRKMD QAGLGARAKA
1210 1220 1230 1240 1250
PPSLPHSASL RSTGSMSVAS AALVAEPVQN GSRSRQQSSS SRESPVPKVR
1260 1270 1280 1290 1300
AIQRQQTQQV QSPVDSATMS PVERTAAWVL NNGQYEEDVE ETEQNQDEAK
1310 1320 1330 1340 1350
HAEKQQEHGR SDSIYHITLG SLARKCISNF NTNIIPVIHA SSPCQYEQEI
1360 1370 1380 1390 1400
SKLKERLRVS SRRLEEYERR LLVQEQQMQK LLLEYKARLE DSEERLRRQQ
1410 1420 1430 1440 1450
EEKDSQMKSI ISRLMAVEEE LKKDHAEMQA VIDAKQKIID AQEKRIVSLD
1460 1470 1480 1490
SANTRLMSAL TQVKERYSMQ VRNGISPTNP TKLSITENGE FKNSSC
Length:1,496
Mass (Da):168,133
Last modified:September 3, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i120C9D7E2F1CD653
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KE680466 Genomic DNA Translation: ERE72404.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KE680466 Genomic DNA Translation: ERE72404.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR021887, DUF3498
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
PANTHERiPTHR10194, PTHR10194, 2 hits
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF12004, DUF3498, 1 hit
PF00616, RasGAP, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A061HYI1_CRIGR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A061HYI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: June 2, 2021
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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