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Protein
Submitted name:

Piezo-type mechanosensitive ion channel component

Gene

pezo-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Piezo-type mechanosensitive ion channel componentImported
Gene namesi
Name:pezo-1Imported
ORF Names:C10C5.1Imported, CELE_C10C5.1Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC10C5.1k ; CE49828 ; WBGene00007505 ; pezo-1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei114 – 133HelicalSequence analysisAdd BLAST20
Transmembranei176 – 197HelicalSequence analysisAdd BLAST22
Transmembranei287 – 308HelicalSequence analysisAdd BLAST22
Transmembranei349 – 368HelicalSequence analysisAdd BLAST20
Transmembranei409 – 428HelicalSequence analysisAdd BLAST20
Transmembranei434 – 453HelicalSequence analysisAdd BLAST20
Transmembranei474 – 496HelicalSequence analysisAdd BLAST23
Transmembranei863 – 887HelicalSequence analysisAdd BLAST25
Transmembranei899 – 922HelicalSequence analysisAdd BLAST24
Transmembranei953 – 971HelicalSequence analysisAdd BLAST19
Transmembranei1075 – 1094HelicalSequence analysisAdd BLAST20
Transmembranei1114 – 1136HelicalSequence analysisAdd BLAST23
Transmembranei1145 – 1163HelicalSequence analysisAdd BLAST19
Transmembranei1287 – 1311HelicalSequence analysisAdd BLAST25
Transmembranei1595 – 1616HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiA0A061AL01

Expressioni

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Structurei

3D structure databases

SMRiA0A061AL01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini488 – 703PIEZOInterPro annotationAdd BLAST216
Domaini1226 – 1679Piezo_RRas_bdgInterPro annotationAdd BLAST454

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili592 – 612Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00390000013029

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

A0A061AL01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQLKFFHGP WSRATSPRRA ENDPPTSTTE AAAVASTSGT QGRAHAAGDT
60 70 80 90 100
LVKKLHKLAN QTIELLWRFF EVHISKIVFV IIAIFIANNI NALYIPLVIL
110 120 130 140 150
LSLAICLPSA ADGIFSLFMC AYLFLVALSK MIYQLDIVPE LSQIDRGVGA
160 170 180 190 200
DNCSHGNISM PEWFGLKKEV EGTEPIYMLF GVIVSIIALA FQSIVIYRQR
210 220 230 240 250
HYRASLGLPE SMRAKVFPDF HHSHFDRSLK NAIQFLIDYG FYKFGLEITM
260 270 280 290 300
IAIGIDIFNR MDALAAIQCF WLVLFALNKR VFVRRIWVFY VIYMAILYPL
310 320 330 340 350
QFFSYVGLPP DSCIEYPWSY WIPSYSDDAR FNLSYLLNLS IYGVNWPSAY
360 370 380 390 400
LIGDFFVLLL ASCQLAVFRR EGEDNDSIYN DGNFVIKPEN PQYDFIDTKK
410 420 430 440 450
SYVDYFKSFV FHYGHWITLM STLAAGIAGT SLFALGYIIF TLTMLWSGNN
460 470 480 490 500
LYVMNSTLRS FEHTLKRWNA LLGYTLFTIT MKVCLQIFGC VFLSWFDQSG
510 520 530 540 550
GWGKTLCIVR QLFSITCVNN ECHVLKELED FSKACAVETK EGNIGFDVIA
560 570 580 590 600
LSFLVFQIRI FHSWYFQHCM VEYRSEVILA NRGAVLKNQL IEKEMKEQNE
610 620 630 640 650
QQKAKFNDIR RRTEAIRERY QKQIERGAAE RDFEPVTYGH AKRAGDYYMF
660 670 680 690 700
KYDPENDDLV EPVDSFVPEV DPKATAYDRL DPGQIMYAAT AHDLDLAKTV
710 720 730 740 750
QQVKKGDTIK DPDSRALIAV SEPEARKPGG TEETDGDEDE DNKDSKVEST
760 770 780 790 800
AKFIQKMIAS ALDLCSVTLN KLCREHRYVG FVLSKEKQKL KSGHSESLSN
810 820 830 840 850
TSRKLTDIRS AVDLPSLQLV QSANDVEKME TAVSVDWQQK SSATRLLNAV
860 870 880 890 900
VNCIGAHTDI LCYFFAIMTQ VMTGGLITLP LPLMSLFWGN LSNPRPSKFF
910 920 930 940 950
WVTMITYTEC VIVIKFVCQF AFMPYNSITW RTEHQMDPMS LDKLFGVSQR
960 970 980 990 1000
DSFALWDIVL LFSLFFHRYM LRKLGLWKDA NLTDTFTLKE EPRSASGSDT
1010 1020 1030 1040 1050
GSPKKIAQEP KVVVTQSDTL EGTSGGEIVI PSDPNAVSNM EELDCEPPIP
1060 1070 1080 1090 1100
EKQSGPIGRF IHQLFHPKFR YIRDLYPIMF GIDVICFLIM TFGYSAFGEG
1110 1120 1130 1140 1150
GSGNVLDDVK ASRIPVTLVV MLVGMTLAII IDRALYLRKS VVGKLIYQVL
1160 1170 1180 1190 1200
MIAFLHIWVF LVLPNMTRRS AISNHVAQAL YVIKSCYFLV SAWQIRNGYP
1210 1220 1230 1240 1250
ELCIGNLLTH SYGMTNMIAF KVFMNIPFLF ELRTAIDWTW TDTSMPLFDF
1260 1270 1280 1290 1300
FNMENFYAHI FNIKCARQFE AAYPAPRGIP KGKLVKYMMG FPIIIGVVIF
1310 1320 1330 1340 1350
IFSPLLLWSL LNQIGTISMP EKVTLRISIE GYPPLYEMEA QGSNHDNAEL
1360 1370 1380 1390 1400
GMIKPDQLAS LNQALTDSYT TRDTNSILRS RMSVSYLKGY TYEDILIVRF
1410 1420 1430 1440 1450
RPESEIYWPI SQDSRNAMID KLSRNTSVNF EVSLEFTRPY DPNENAALKH
1460 1470 1480 1490 1500
SKSWLVPISL DMTIRAKIQS ALRGDPGHPI LIPQSIPAFI QVPNQGELTL
1510 1520 1530 1540 1550
PTSIGNTIIN DGNPRINTTG MEKSDEARAW FDSLTLNLEQ GKSQNEKMWI
1560 1570 1580 1590 1600
ATSEHPGDQN AKLWIKTANT TYSGRPYLQV VGFIDRAFPS FLAKVFKGGV
1610 1620 1630 1640 1650
IAVYLSVILV VGRGLVRGIF TTSPSTVMFT ELPNADHLLK ICLDIYLVRE
1660 1670 1680
AKDFMLEQDL FAKLIFLFRS PATLIEWTRM SKKKQE
Length:1,686
Mass (Da):191,615
Last modified:September 3, 2014 - v1
Checksum:iF84C411748336B88
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A061ACU2A0A061ACU2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,442Annotation score:
D0VWN8D0VWN8_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:
C6KRJ3C6KRJ3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,400Annotation score:
Q17897Q17897_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,438Annotation score:
H9G2S2H9G2S2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:
H9G2S3H9G2S3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:
A0A061AJB7A0A061AJB7_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,404Annotation score:
A0A061AE33A0A061AE33_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:
O01260O01260_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,704Annotation score:
B9WRT3B9WRT3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,730Annotation score:
There is more potential isoformShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CDR32752.1
RefSeqiNP_001293982.1, NM_001307053.1

Genome annotation databases

EnsemblMetazoaiC10C5.1k; C10C5.1k; WBGene00007505
GeneIDi182492

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CDR32752.1
RefSeqiNP_001293982.1, NM_001307053.1

3D structure databases

SMRiA0A061AL01
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA0A061AL01

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC10C5.1k; C10C5.1k; WBGene00007505
GeneIDi182492

Organism-specific databases

CTDi182492
WormBaseiC10C5.1k ; CE49828 ; WBGene00007505 ; pezo-1

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00390000013029

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A061AL01_CAEEL
AccessioniPrimary (citable) accession number: A0A061AL01
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: October 10, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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