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Entry version 36 (05 Jun 2019)
Sequence version 1 (03 Sep 2014)
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Protein

Piezo-type mechanosensitive ion channel component

Gene

pezo-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channelUniRule annotation
Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Piezo-type mechanosensitive ion channel componentUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pezo-1Imported
ORF Names:C10C5.1Imported, CELE_C10C5.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
C10C5.1g ; CE49794 ; WBGene00007505 ; pezo-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 45HelicalUniRule annotationAdd BLAST26
Transmembranei57 – 81HelicalUniRule annotationAdd BLAST25
Transmembranei122 – 143HelicalUniRule annotationAdd BLAST22
Transmembranei175 – 199HelicalUniRule annotationAdd BLAST25
Transmembranei211 – 229HelicalUniRule annotationAdd BLAST19
Transmembranei241 – 264HelicalUniRule annotationAdd BLAST24
Transmembranei307 – 325HelicalUniRule annotationAdd BLAST19
Transmembranei454 – 473HelicalUniRule annotationAdd BLAST20
Transmembranei479 – 499HelicalUniRule annotationAdd BLAST21
Transmembranei506 – 527HelicalUniRule annotationAdd BLAST22
Transmembranei551 – 573HelicalUniRule annotationAdd BLAST23
Transmembranei629 – 650HelicalUniRule annotationAdd BLAST22
Transmembranei656 – 673HelicalUniRule annotationAdd BLAST18
Transmembranei685 – 705HelicalUniRule annotationAdd BLAST21
Transmembranei742 – 760HelicalUniRule annotationAdd BLAST19
Transmembranei821 – 842HelicalUniRule annotationAdd BLAST22
Transmembranei848 – 863HelicalUniRule annotationAdd BLAST16
Transmembranei870 – 889HelicalUniRule annotationAdd BLAST20
Transmembranei932 – 953HelicalUniRule annotationAdd BLAST22
Transmembranei1043 – 1064HelicalUniRule annotationAdd BLAST22
Transmembranei1105 – 1124HelicalUniRule annotationAdd BLAST20
Transmembranei1165 – 1184HelicalUniRule annotationAdd BLAST20
Transmembranei1190 – 1209HelicalUniRule annotationAdd BLAST20
Transmembranei1230 – 1252HelicalUniRule annotationAdd BLAST23
Transmembranei1619 – 1643HelicalUniRule annotationAdd BLAST25
Transmembranei1655 – 1678HelicalUniRule annotationAdd BLAST24
Transmembranei1709 – 1727HelicalUniRule annotationAdd BLAST19
Transmembranei1831 – 1850HelicalUniRule annotationAdd BLAST20
Transmembranei1870 – 1892HelicalUniRule annotationAdd BLAST23
Transmembranei1901 – 1919HelicalUniRule annotationAdd BLAST19
Transmembranei2043 – 2067HelicalUniRule annotationAdd BLAST25
Transmembranei2351 – 2372HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A061ACU2 baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A061ACU2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1244 – 1459PIEZOInterPro annotationAdd BLAST216
Domaini1982 – 2435Piezo_RRas_bdgInterPro annotationAdd BLAST454

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni389 – 417DisorderedSequence analysisAdd BLAST29
Regioni768 – 798DisorderedSequence analysisAdd BLAST31
Regioni1463 – 1502DisorderedSequence analysisAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1348 – 1368Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi775 – 798PolarSequence analysisAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PIEZO (TC 1.A.75) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1893 Eukaryota
ENOG410YVF6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166986

Identification of Orthologs from Complete Genome Data

More...
OMAi
VVYKILY

Database of Orthologous Groups

More...
OrthoDBi
13738at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13167 PTHR13167, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

A0A061ACU2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVPPLLKSC VVKLLLPAAL LAAAIIRPSF LSIGYVLLAL VSAVLPPIRK
60 70 80 90 100
SLALPKLVGT FVIITFLFCL AVALGVGSYQ ISEQVVHKND RTYICNRSDT
110 120 130 140 150
TLFRSIGLVR FHPTGTFEST RAFLPEIIAT SAALLTIIIV MFLSHRDEQL
160 170 180 190 200
DVVGDVVTVR SESGREQRRQ RKLAAIMWSA IGNSLRRLTN FVLFLFTAYV
210 220 230 240 250
GIVKPSLSNS IYFLAFLFIS TWWSTYTPLR HGVYNQIKKF LIFYSALHFL
260 270 280 290 300
VLYTYQIPIV HHSWLPTGSF LPRLFGLTVL MDSSCPEWWK FPFVAPDFND
310 320 330 340 350
DDLIMKWPLY ANPIVVLVFF YLTVAQYKFT RNGSREYIDD NEYGSSVHEE
360 370 380 390 400
RFVSAGTVET NVDDVGQLIS ISESTASAPS GRGRGNTLLL SNASSSANDD
410 420 430 440 450
EQGRARSRSP LRNGEEQGSI PLRKVTSQVV DRNKLSNIFN TTAPGDKESA
460 470 480 490 500
ASKGMIAVMT FVIFHSYSIA LTAMMTWALL YHSIFGLILL ILTCILWIFR
510 520 530 540 550
DTRKSSFAMA PIILMYIEFL LILQYFLSMD IHAEIGDPAW MNFVGIEWTT
560 570 580 590 600
LPVHAVIILC VQTLLTLPVF LLLRLARREK FYESLSDYER QRRINSYGTF
610 620 630 640 650
GASKTGAGGV AVAKFQDPKS RKFAAFVEYL SNKVSVYFIF VVSVVLLVVS
660 670 680 690 700
TCFAPNFYNI LFFALWALNL IYLKFSFRLY RGLAYAFWLT LTFYTSIVII
710 720 730 740 750
ALYIYQFPGV SQWIIRNTSL SQEWLNAIGL VDFRAIGESG ALFLQLLAPI
760 770 780 790 800
ALFVVTMLQL KFFHGPWSRA TSPRRAENDP PTSTTEAAAV ASTSGTQGRA
810 820 830 840 850
HAAGDTLVKK LHKLANQTIE LLWRFFEVHI SKIVFVIIAI FIANNINALY
860 870 880 890 900
IPLVILLSLA ICLPSAADGI FSLFMCAYLF LVALSKMIYQ LDIVPELSQI
910 920 930 940 950
DRGVGADNCS HGNISMPEWF GLKKEVEGTE PIYMLFGVIV SIIALAFQSI
960 970 980 990 1000
VIYRQRHYRA SLGLPESMRA KVFPDFHHSH FDRSLKNAIQ FLIDYGFYKF
1010 1020 1030 1040 1050
GLEITMIAIG IDIFNRMDAL AAIQCFWLVL FALNKRVFVR RIWVFYVIYM
1060 1070 1080 1090 1100
AILYPLQFFS YVGLPPDSCI EYPWSYWIPS YSDDARFNLS YLLNLSIYGV
1110 1120 1130 1140 1150
NWPSAYLIGD FFVLLLASCQ LAVFRREGED NDSIYNDGNF VIKPENPQYD
1160 1170 1180 1190 1200
FIDTKKSYVD YFKSFVFHYG HWITLMSTLA AGIAGTSLFA LGYIIFTLTM
1210 1220 1230 1240 1250
LWSGNNLYVM NSTLRSFEHT LKRWNALLGY TLFTITMKVC LQIFGCVFLS
1260 1270 1280 1290 1300
WFDQSGGWGK TLCIVRQLFS ITCVNNECHV LKELEDFSKA CAVETKEGNI
1310 1320 1330 1340 1350
GFDVIALSFL VFQIRIFHSW YFQHCMVEYR SEVILANRGA VLKNQLIEKE
1360 1370 1380 1390 1400
MKEQNEQQKA KFNDIRRRTE AIRERYQKQI ERGAAERDFE PVTYGHAKRA
1410 1420 1430 1440 1450
GDYYMFKYDP ENDDLVEPVD SFVPEVDPKA TAYDRLDPGQ IMYAATAHDL
1460 1470 1480 1490 1500
DLAKTVQQVK KGDTIKDPDS RALIAVSEPE ARKPGGTEET DGDEDEDNKD
1510 1520 1530 1540 1550
SKVESTAKFI QKMIASALDL CSVTLNKLCR EHRYVGFVLS KEKQKLKSGH
1560 1570 1580 1590 1600
SESLSNTSRK LTDIRSAVDL PSLQLVQSAN DVEKMETAVS VDWQQKSSAT
1610 1620 1630 1640 1650
RLLNAVVNCI GAHTDILCYF FAIMTQVMTG GLITLPLPLM SLFWGNLSNP
1660 1670 1680 1690 1700
RPSKFFWVTM ITYTECVIVI KFVCQFAFMP YNSITWRTEH QMDPMSLDKL
1710 1720 1730 1740 1750
FGVSQRDSFA LWDIVLLFSL FFHRYMLRKL GLWKDANLTD TFTLKEEPRS
1760 1770 1780 1790 1800
ASGSDTGSPK KIAQEPKVVV TQSDTLEGTS GGEIVIPSDP NAVSNMEELD
1810 1820 1830 1840 1850
CEPPIPEKQS GPIGRFIHQL FHPKFRYIRD LYPIMFGIDV ICFLIMTFGY
1860 1870 1880 1890 1900
SAFGEGGSGN VLDDVKASRI PVTLVVMLVG MTLAIIIDRA LYLRKSVVGK
1910 1920 1930 1940 1950
LIYQVLMIAF LHIWVFLVLP NMTRRSAISN HVAQALYVIK SCYFLVSAWQ
1960 1970 1980 1990 2000
IRNGYPELCI GNLLTHSYGM TNMIAFKVFM NIPFLFELRT AIDWTWTDTS
2010 2020 2030 2040 2050
MPLFDFFNME NFYAHIFNIK CARQFEAAYP APRGIPKGKL VKYMMGFPII
2060 2070 2080 2090 2100
IGVVIFIFSP LLLWSLLNQI GTISMPEKVT LRISIEGYPP LYEMEAQGSN
2110 2120 2130 2140 2150
HDNAELGMIK PDQLASLNQA LTDSYTTRDT NSILRSRMSV SYLKGYTYED
2160 2170 2180 2190 2200
ILIVRFRPES EIYWPISQDS RNAMIDKLSR NTSVNFEVSL EFTRPYDPNE
2210 2220 2230 2240 2250
NAALKHSKSW LVPISLDMTI RAKIQSALRG DPGHPILIPQ SIPAFIQVPN
2260 2270 2280 2290 2300
QGELTLPTSI GNTIINDGNP RINTTGMEKS DEARAWFDSL TLNLEQGKSQ
2310 2320 2330 2340 2350
NEKMWIATSE HPGDQNAKLW IKTANTTYSG RPYLQVVGFI DRAFPSFLAK
2360 2370 2380 2390 2400
VFKGGVIAVY LSVILVVGRG LVRGIFTTSP STVMFTELPN ADHLLKICLD
2410 2420 2430 2440
IYLVREAKDF MLEQDLFAKL IFLFRSPATL IEWTRMSKKK QE
Length:2,442
Mass (Da):276,793
Last modified:September 3, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB7D9F5248DB4814
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D0VWN8D0VWN8_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C6KRJ3C6KRJ3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,400Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q17897Q17897_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,438Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9G2S3H9G2S3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,440Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AJB7A0A061AJB7_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,404Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9G2S2H9G2S2_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AE33A0A061AE33_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
2,402Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A061AL01A0A061AL01_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,686Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O01260O01260_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,704Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B9WRT3B9WRT3_CAEEL
Piezo-type mechanosensitive ion cha...
pezo-1 C10C5.1, CELE_C10C5.1
1,730Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CDR32750.1

NCBI Reference Sequences

More...
RefSeqi
NP_001293980.1, NM_001307051.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C10C5.1g; C10C5.1g; WBGene00007505

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
182492

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284604 Genomic DNA Translation: CDR32750.1
RefSeqiNP_001293980.1, NM_001307051.1

3D structure databases

SMRiA0A061ACU2
ModBaseiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC10C5.1g; C10C5.1g; WBGene00007505
GeneIDi182492

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
182492
WormBaseiC10C5.1g ; CE49794 ; WBGene00007505 ; pezo-1

Phylogenomic databases

eggNOGiKOG1893 Eukaryota
ENOG410YVF6 LUCA
GeneTreeiENSGT00940000166986
OMAiVVYKILY
OrthoDBi13738at2759

Gene expression databases

BgeeiWBGene00007505 Expressed in 4 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiA0A061ACU2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR027272 Piezo
IPR031805 Piezo_dom
IPR031334 Piezo_RRas-bd_dom
PANTHERiPTHR13167 PTHR13167, 1 hit
PfamiView protein in Pfam
PF15917 PIEZO, 1 hit
PF12166 Piezo_RRas_bdg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A061ACU2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A061ACU2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: June 5, 2019
This is version 36 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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