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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Wolbachia endosymbiont of Cimex lectularius
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei617ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotationImported
ORF Names:WCLE_001130Imported
OrganismiWolbachia endosymbiont of Cimex lectulariusImported
Taxonomic identifieri246273 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000031663 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 165tRNA-synt_1InterPro annotationAdd BLAST149
Domaini216 – 415tRNA-synt_1_2InterPro annotationAdd BLAST200
Domaini428 – 580tRNA-synt_1InterPro annotationAdd BLAST153
Domaini612 – 654tRNA-synt_1InterPro annotationAdd BLAST43
Domaini696 – 811Anticodon_1InterPro annotationAdd BLAST116

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionUniRule annotationAdd BLAST11
Motifi614 – 618"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK01869

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A060PUR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDFKNVEK FYQDKWNFSV SKNSKQEKCY VLEMFPYPSG KIHMGHLRNY
60 70 80 90 100
AIGDVIARYK RACGFEVLHP IGWDAFGLPA ENAARDNNIS PAAWTKENID
110 120 130 140 150
SMHAQLRSIG LSYNWERELS TCEPDYYKHE QKFFLDFLKH GLAYRKESWV
160 170 180 190 200
NWDPVDQTVL ANEQVVDGKG WRSGTVVEKR KLSQWFLKIT DFAEDLLKCL
210 220 230 240 250
QDLKNWPEKV KTMQERWIGK SEGVIIEFEI VGLNKKLKIF TTSPHTLFGA
260 270 280 290 300
SFLAVAAEHP IVQDIMLPDA PEVLSSQCFD TGIQQKDEWI PASRTGMTID
310 320 330 340 350
NINTKGENDE KFGIYTGLNV KHPFLDKELP LYIANFVLME YGEGAIFGCP
360 370 380 390 400
AHDQRDFEFV QKYDLPIIPV VREEVPQATE TLKEVYTGDG VMFNSEFLNG
410 420 430 440 450
LTVSKAKEVA IKKLEEKGIG KKTINYRLHD WGISRQRYWG CPIPIIYCKD
460 470 480 490 500
CGTVQVPERD LPVVLPTDVE FTSGGNPLDK HPTWKFVDCP KCGKQAERET
510 520 530 540 550
DTFDTFFESS WYFAAFCSEN KSINKDACNR FMPVDYYIGG IEHAILHLLY
560 570 580 590 600
SRFFCRALTK CGYLDTKEPF STLITQGMVC HVTYKDENGK WLFPEEAKEL
610 620 630 640 650
MAQGAEVQVG KVEKMSKSKK NTVDPNFIIE KYGADTARLF VLSDTPPEKD
660 670 680 690 700
MEWSDDGVEG CSRYINKLWR MVMQLRPVNM RYDNESVTGK LLEYRKKIHK
710 720 730 740 750
LLHGLTDDLE SCRLNCVVAK FREMTNLIAE IDVKDGKSLI DEGICILIRV
760 770 780 790 800
IEPFIPHLAE NLWQEIRDEG MLYLKPWPQA TKSLLIDDVV TVAVQINGKL
810 820 830 840
RTTIEVAADL SQEELKKIAI DSVSNRIDQS KVRAIYAVPN KIVNIVI
Length:847
Mass (Da):97,193
Last modified:September 3, 2014 - v1
Checksum:iA0A8736A86C003DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP013028 Genomic DNA Translation: BAO99432.1
RefSeqiWP_041045089.1, NZ_AP013028.1

Genome annotation databases

EnsemblBacteriaiBAO99432; BAO99432; WCLE_001130
KEGGiwcl:WCLE_001130

Similar proteinsi

Entry informationi

Entry nameiA0A060PUR9_9RICK
AccessioniPrimary (citable) accession number: A0A060PUR9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 3, 2014
Last sequence update: September 3, 2014
Last modified: June 20, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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