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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Enterococcus faecalis 918
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
ORF Names:HMPREF2097_00887Imported
OrganismiEnterococcus faecalis 918Imported
Taxonomic identifieri1338519 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000026654 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 28HelicalUniRule annotationAdd BLAST23
Transmembranei54 – 74HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 97HelicalUniRule annotationAdd BLAST18
Transmembranei117 – 133HelicalUniRule annotationAdd BLAST17
Transmembranei145 – 165HelicalUniRule annotationAdd BLAST21
Transmembranei177 – 196HelicalUniRule annotationAdd BLAST20
Transmembranei202 – 219HelicalUniRule annotationAdd BLAST18
Transmembranei226 – 247HelicalUniRule annotationAdd BLAST22
Transmembranei253 – 278HelicalUniRule annotationAdd BLAST26
Transmembranei299 – 320HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A059N462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWTQIFIPI VVSFAITVSV MPLFIGYFQM KKQGQVTRED GPTWHSVKTG
60 70 80 90 100
TPTMGGVVFL VASLITSLAM GLFFHQFTPS LLIILFILVL YGLLGYLDDF
110 120 130 140 150
IKVFKKRNMG LNSRQKLIGQ IFGGLVFYFV YRSEGFSDTL DLFGVAEVPL
160 170 180 190 200
GIFYGVFIIF WLVGFSNAVN LTDGIDGLVA GLGTISFGTY AIIAWKQQQF
210 220 230 240 250
DVVIICLSVI GGLIGFFPYN RKPAKIFMGD VGSLALGGLL AAISIILHQE
260 270 280 290 300
WTLLLIGLVY VCETASVILQ VASFKLFGRR IFKMSPIHHH FEMCGWSEWK
310 320
IDFVFWSVGL ICSGITLWIL F
Length:321
Mass (Da):35,814
Last modified:July 9, 2014 - v1
Checksum:iE1525D0C07FAEB92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AVNY01000044 Genomic DNA Translation: KDE18051.1
RefSeqiWP_002355894.1, NZ_KK640435.1

Genome annotation databases

EnsemblBacteriaiKDE18051; KDE18051; HMPREF2097_00887
PATRICifig|1338519.3.peg.808

Entry informationi

Entry nameiA0A059N462_ENTFL
AccessioniPrimary (citable) accession number: A0A059N462
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 27, 2017
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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