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Entry version 60 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA

Gene

tlyA

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseImported, RNA-bindingPROSITE-ProRule annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyAImported
Submitted name:
Cytotoxin / haemolysin homologue TlyAImported (EC:2.1.1.226Imported)
Submitted name:
Mutant TlyAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tlyAImported
ORF Names:DSI38_13410Imported, E5M52_14020Imported, ERS007663_03298Imported, ERS007720_00106Imported, ERS007741_00698Imported, ERS013471_00042Imported, ERS023446_01647Imported, ERS024276_00313Imported, ERS027646_00010Imported, ERS027659_02052Imported, ERS027661_00747Imported, ERS075361_02685Imported, ERS094182_03076Imported, F6W99_00251Imported, F9908_10990Imported, SAMEA2683035_01391Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000048948 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000431688 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 67S4 RNA-bindingInterPro annotationAdd BLAST63

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00165, S4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.290.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004538, Haemolysin_A/TlyA
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR002942, S4_RNA-bd
IPR036986, S4_RNA-bd_sf
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR32319:SF0, PTHR32319:SF0, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01728, FtsJ, 1 hit
PF01479, S4, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005578, TlyA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00363, S4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00478, tly, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50889, S4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045KH60-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRARVDAE LVRRGLARSR QQAAELIGAG KVRIDGLPAV KPATAVSDTT
60 70 80 90 100
ALTVVTDSER AWVSRGAHKL VGALEAFAIA VAGRRCLDAG ASTGGFTEVL
110 120 130 140 150
LDRGAAHVVA ADVGYGQLAW SLRNDPRVVV LERTNARGLT PEAIGGRVDL
160 170 180 190 200
VVADLSFISL ATVLPALVGC ASRDADIVPL VKPQFEVGKG QVGPGGVVHD
210 220 230 240 250
PQLRARSVLA VARRAQELGW HSVGVKASPL PGPSGNVEYF LWLRTQTDRA
260
LSAKGLEDAV HRAISEGP
Length:268
Mass (Da):28,074
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB62AB8400CCC71CE
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KJ872561 Genomic DNA Translation: AIL27673.1
CNCN01000039 Genomic DNA Translation: CKN74207.1
CNFU01000102 Genomic DNA Translation: CKR18399.1
CNGE01000001 Genomic DNA Translation: CKR55356.1
CNFT01000445 Genomic DNA Translation: CKR71332.1
CQAC01000020 Genomic DNA Translation: CNG92001.1
CQGE01000028 Genomic DNA Translation: CNM93294.1
CQPV01000635 Genomic DNA Translation: CNV43932.1
CQTT01000001 Genomic DNA Translation: CNY00746.1
CSAJ01000006 Genomic DNA Translation: COV39133.1
CHKL01000047 Genomic DNA Translation: COV80775.1
CVKR01000025 Genomic DNA Translation: CRF27611.1
WFKV01000011 Genomic DNA Translation: KAB7804216.1
CP044345 Genomic DNA Translation: QEX89478.1
QSXJ01000937 Genomic DNA Translation: REM66643.1
FPTZ01000007 Genomic DNA Translation: SGH54046.1
SRLJ01000031 Genomic DNA Translation: TGD74450.1

NCBI Reference Sequences

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RefSeqi
WP_003408382.1, NZ_WUJD01000016.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC46081; AMC46081; RN05_1805
CKN74207; CKN74207; ERS024276_00313
CKR18399; CKR18399; ERS027661_00747
CKR31286; CKR31286; ERS027644_00955
CKR39219; CKR39219; ERS027656_01181
CKR55356; CKR55356; ERS027646_00010
CKR71332; CKR71332; ERS027659_02052
CKU00293; CKU00293; ERS027666_03667
CKV16028; CKV16028; ERS031537_02103
CNG50169; CNG50169; ERS124361_01105
CNM93294; CNM93294; ERS023446_01647
CNV43932; CNV43932; ERS007663_03298
CNY00746; CNY00746; ERS013471_00042
COV39133; COV39133; ERS007720_00106
COV80775; COV80775; ERS007741_00698
CRH11935; CRH11935; BN1303_01357
CRH14532; CRH14532; BN1213_02840

Database of genes from NCBI RefSeq genomes

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GeneIDi
23492139

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.3216

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KJ872561 Genomic DNA Translation: AIL27673.1
CNCN01000039 Genomic DNA Translation: CKN74207.1
CNFU01000102 Genomic DNA Translation: CKR18399.1
CNGE01000001 Genomic DNA Translation: CKR55356.1
CNFT01000445 Genomic DNA Translation: CKR71332.1
CQAC01000020 Genomic DNA Translation: CNG92001.1
CQGE01000028 Genomic DNA Translation: CNM93294.1
CQPV01000635 Genomic DNA Translation: CNV43932.1
CQTT01000001 Genomic DNA Translation: CNY00746.1
CSAJ01000006 Genomic DNA Translation: COV39133.1
CHKL01000047 Genomic DNA Translation: COV80775.1
CVKR01000025 Genomic DNA Translation: CRF27611.1
WFKV01000011 Genomic DNA Translation: KAB7804216.1
CP044345 Genomic DNA Translation: QEX89478.1
QSXJ01000937 Genomic DNA Translation: REM66643.1
FPTZ01000007 Genomic DNA Translation: SGH54046.1
SRLJ01000031 Genomic DNA Translation: TGD74450.1
RefSeqiWP_003408382.1, NZ_WUJD01000016.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC46081; AMC46081; RN05_1805
CKN74207; CKN74207; ERS024276_00313
CKR18399; CKR18399; ERS027661_00747
CKR31286; CKR31286; ERS027644_00955
CKR39219; CKR39219; ERS027656_01181
CKR55356; CKR55356; ERS027646_00010
CKR71332; CKR71332; ERS027659_02052
CKU00293; CKU00293; ERS027666_03667
CKV16028; CKV16028; ERS031537_02103
CNG50169; CNG50169; ERS124361_01105
CNM93294; CNM93294; ERS023446_01647
CNV43932; CNV43932; ERS007663_03298
CNY00746; CNY00746; ERS013471_00042
COV39133; COV39133; ERS007720_00106
COV80775; COV80775; ERS007741_00698
CRH11935; CRH11935; BN1303_01357
CRH14532; CRH14532; BN1213_02840
GeneIDi23492139
PATRICifig|1773.206.peg.3216

Family and domain databases

CDDicd00165, S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR004538, Haemolysin_A/TlyA
IPR002877, rRNA_MeTrfase_FtsJ_dom
IPR002942, S4_RNA-bd
IPR036986, S4_RNA-bd_sf
IPR029063, SAM-dependent_MTases
PANTHERiPTHR32319:SF0, PTHR32319:SF0, 1 hit
PfamiView protein in Pfam
PF01728, FtsJ, 1 hit
PF01479, S4, 1 hit
PIRSFiPIRSF005578, TlyA, 1 hit
SMARTiView protein in SMART
SM00363, S4, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
TIGRFAMsiTIGR00478, tly, 1 hit
PROSITEiView protein in PROSITE
PS50889, S4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045KH60_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045KH60
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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