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Entry version 63 (17 Jun 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

HTH-type transcriptional regulator

Gene

AYJ03_009630

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HTH-type transcriptional regulatorImported
Submitted name:
MerR family DNA-binding transcriptional regulatorImported
Submitted name:
MerR family transcriptional regulatorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AYJ03_009630Imported, DSI38_20985Imported, E5M05_05955Imported, ERS007663_00643Imported, ERS007670_01688Imported, ERS007679_02165Imported, ERS007681_01195Imported, ERS007688_01732Imported, ERS007720_01275Imported, ERS007722_03043Imported, ERS007741_01862Imported, ERS013471_01901Imported, ERS023446_03418Imported, ERS024276_00819Imported, ERS027646_02085Imported, ERS027659_02841Imported, ERS027661_02413Imported, ERS075361_01459Imported, ERS094182_01222Imported, F6W99_00389Imported, FRD82_10430Imported, GJE03_09570Imported, SAMEA2683035_00861Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000075723 Componenti: Chromosome
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000388593 Componenti: Chromosome
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 85HTH merR-typeInterPro annotationAdd BLAST75

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108WBP Bacteria
COG0789 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00376 MerR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00422 HTH_MERR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50937 HTH_MERR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045KFK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPDSPALA GMSIGAVLDL LRPDFPDVTI SKIRFLEAEG LVTPRRASSG
60 70 80 90 100
YRRFTAYDCA RLRFILTAQR DHYLPLKVIR AQLDAQPDGE LPPFGSPYVL
110 120 130 140 150
PRLVPVAGDS AGGVGSDTAS VSLTGIRLSR EDLLERSEVA DELLTALLKA
160 170 180 190 200
GVITTGPGGF FDEHAVVILQ CARALAEYGV EPRHLRAFRS AADRQSDLIA
210 220 230 240
QIAGPLVKAG KAGARDRADD LAREVAALAI TLHTSLIKSA VRDVLHR
Length:247
Mass (Da):26,443
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3BA9AE7E08B3D37
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000110 Genomic DNA Translation: CFE38826.1
CFOH01000241 Genomic DNA Translation: CFE50511.1
CNCN01000133 Genomic DNA Translation: CKN98758.1
CNFU01000508 Genomic DNA Translation: CKR97795.1
CNFT01000738 Genomic DNA Translation: CKS25173.1
CNGE01000357 Genomic DNA Translation: CKS56503.1
CQAC01000008 Genomic DNA Translation: CNG51660.1
CQGE01000106 Genomic DNA Translation: CNN43075.1
CQPV01000063 Genomic DNA Translation: CNU16841.1
CQPL01000291 Genomic DNA Translation: CNU55846.1
CQTT01000045 Genomic DNA Translation: CNY54079.1
CSAD01000279 Genomic DNA Translation: COV61476.1
CSAJ01000121 Genomic DNA Translation: COV95322.1
CHKL01000182 Genomic DNA Translation: COW22270.1
CSAM01000274 Genomic DNA Translation: COW59536.1
CVKR01000007 Genomic DNA Translation: CRF25793.1
CP044345 Genomic DNA Translation: QEX89615.1
CP045962 Genomic DNA Translation: QGK79034.1
CP046529 Genomic DNA Translation: QGV21492.1
QSXJ01001068 Genomic DNA Translation: REM61828.1
FPTZ01000004 Genomic DNA Translation: SGH32679.1
SRLI01000010 Genomic DNA Translation: TGE05676.1
VOOQ01000276 Genomic DNA Translation: TXB93436.1

NCBI Reference Sequences

More...
RefSeqi
WP_003409239.1, NZ_WJSJ01000062.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC46229; AMC46229; RN05_1953
CFE38826; CFE38826; ERS007681_01195
CFE50511; CFE50511; ERS007688_01732
CKN98758; CKN98758; ERS024276_00819
CKP46266; CKP46266; ERS024213_02096
CKR67523; CKR67523; ERS027656_01852
CKR77435; CKR77435; ERS027644_02058
CKR97795; CKR97795; ERS027661_02413
CKS25173; CKS25173; ERS027659_02841
CKS56503; CKS56503; ERS027646_02085
CKT04683; CKT04683; ERS027666_02038
CNH18780; CNH18780; ERS124361_03065
CNN43075; CNN43075; ERS023446_03418
CNU16841; CNU16841; ERS007663_00643
CNU55846; CNU55846; ERS007670_01688
CNY54079; CNY54079; ERS013471_01901
COU93734; COU93734; ERS007672_00681
COV61476; COV61476; ERS007679_02165
COV95322; COV95322; ERS007720_01275
COW22270; COW22270; ERS007741_01862
COW59536; COW59536; ERS007722_03043
COX12876; COX12876; ERS007731_01490
CRH10654; CRH10654; BN1303_00774
CRH12610; CRH12610; BN1213_01909

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.1992

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000110 Genomic DNA Translation: CFE38826.1
CFOH01000241 Genomic DNA Translation: CFE50511.1
CNCN01000133 Genomic DNA Translation: CKN98758.1
CNFU01000508 Genomic DNA Translation: CKR97795.1
CNFT01000738 Genomic DNA Translation: CKS25173.1
CNGE01000357 Genomic DNA Translation: CKS56503.1
CQAC01000008 Genomic DNA Translation: CNG51660.1
CQGE01000106 Genomic DNA Translation: CNN43075.1
CQPV01000063 Genomic DNA Translation: CNU16841.1
CQPL01000291 Genomic DNA Translation: CNU55846.1
CQTT01000045 Genomic DNA Translation: CNY54079.1
CSAD01000279 Genomic DNA Translation: COV61476.1
CSAJ01000121 Genomic DNA Translation: COV95322.1
CHKL01000182 Genomic DNA Translation: COW22270.1
CSAM01000274 Genomic DNA Translation: COW59536.1
CVKR01000007 Genomic DNA Translation: CRF25793.1
CP044345 Genomic DNA Translation: QEX89615.1
CP045962 Genomic DNA Translation: QGK79034.1
CP046529 Genomic DNA Translation: QGV21492.1
QSXJ01001068 Genomic DNA Translation: REM61828.1
FPTZ01000004 Genomic DNA Translation: SGH32679.1
SRLI01000010 Genomic DNA Translation: TGE05676.1
VOOQ01000276 Genomic DNA Translation: TXB93436.1
RefSeqiWP_003409239.1, NZ_WJSJ01000062.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC46229; AMC46229; RN05_1953
CFE38826; CFE38826; ERS007681_01195
CFE50511; CFE50511; ERS007688_01732
CKN98758; CKN98758; ERS024276_00819
CKP46266; CKP46266; ERS024213_02096
CKR67523; CKR67523; ERS027656_01852
CKR77435; CKR77435; ERS027644_02058
CKR97795; CKR97795; ERS027661_02413
CKS25173; CKS25173; ERS027659_02841
CKS56503; CKS56503; ERS027646_02085
CKT04683; CKT04683; ERS027666_02038
CNH18780; CNH18780; ERS124361_03065
CNN43075; CNN43075; ERS023446_03418
CNU16841; CNU16841; ERS007663_00643
CNU55846; CNU55846; ERS007670_01688
CNY54079; CNY54079; ERS013471_01901
COU93734; COU93734; ERS007672_00681
COV61476; COV61476; ERS007679_02165
COV95322; COV95322; ERS007720_01275
COW22270; COW22270; ERS007741_01862
COW59536; COW59536; ERS007722_03043
COX12876; COX12876; ERS007731_01490
CRH10654; CRH10654; BN1303_00774
CRH12610; CRH12610; BN1213_01909
PATRICifig|1773.206.peg.1992

Phylogenomic databases

eggNOGiENOG4108WBP Bacteria
COG0789 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF00376 MerR, 1 hit
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
PROSITEiView protein in PROSITE
PS50937 HTH_MERR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045KFK4_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045KFK4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 17, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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