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UniProtKB - A0A045K6P8 (A0A045K6P8_MYCTX)

Entry version 64 (02 Dec 2020)
Sequence version 1 (09 Jul 2014)
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Protein

Ribosome-recycling factor

Gene

frr

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein biosynthesisUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribosome-recycling factorUniRule annotation
Short name:
RRFUniRule annotation
Alternative name(s):
Ribosome-releasing factorUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:frrUniRule annotationImported
ORF Names:DSI38_19340Imported, E5M52_19490Imported, ERS007657_01511Imported, ERS007661_01511Imported, ERS007663_02936Imported, ERS007665_01955Imported, ERS007670_02537Imported, ERS007679_01749Imported, ERS007681_04689Imported, ERS007688_03661Imported, ERS007703_02850Imported, ERS007720_02746Imported, ERS007722_02462Imported, ERS007741_01761Imported, ERS013471_00403Imported, ERS023446_00771Imported, ERS027659_03706Imported, ERS027661_02117Imported, ERS075361_01996Imported, ERS094182_02077Imported, F6W99_01492Imported, SAMEA2683035_02118Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000256245 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 183RRFInterPro annotationAdd BLAST163

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 164DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RRF family.UniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd00520, RRF, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00040, RRF, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002661, Ribosome_recyc_fac
IPR023584, Ribosome_recyc_fac_dom
IPR036191, RRF_sf

The PANTHER Classification System

More...PANTHERi		PTHR20982, PTHR20982, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01765, RRF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55194, SSF55194, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00496, frr, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045K6P8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIDEALFDAE EKMEKAVAVA RDDLSTIRTG RANPGMFSRI TIDYYGAATP 
        60         70         80         90        100
ITQLASINVP EARLVVIKPY EANQLRAIET AIRNSDLGVN PTNDGALIRV 
       110        120        130        140        150
AVPQLTEERR RELVKQAKHK GEEAKVSVRN IRRKAMEELH RIRKEGEAGE 
       160        170        180 
DEVGRAEKDL DKTTHQYVTQ IDELVKHKEG ELLEV
Length:185
Mass (Da):20,828
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8C711A42089F5CA2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CFOE01001290 Genomic DNA Translation: CFE49563.1
CFOH01000844 Genomic DNA Translation: CFE71404.1
CGCX01000472 Genomic DNA Translation: CFR76809.1
CNFU01000421 Genomic DNA Translation: CKR79603.1
CNFT01001132 Genomic DNA Translation: CKS89872.1
CQAC01000013 Genomic DNA Translation: CNG71320.1
CQGE01000010 Genomic DNA Translation: CNM60052.1
CQPW01000368 Genomic DNA Translation: CNU98426.1
CQQC01000427 Genomic DNA Translation: CNV01722.1
CQPL01000556 Genomic DNA Translation: CNV11363.1
CQPV01000515 Genomic DNA Translation: CNV33270.1
CQTT01000006 Genomic DNA Translation: CNY09853.1
CSAD01000202 Genomic DNA Translation: COV39064.1
CSAE01000340 Genomic DNA Translation: COW13348.1
CHKL01000166 Genomic DNA Translation: COW18867.1
CSAM01000184 Genomic DNA Translation: COW33480.1
CSAJ01000376 Genomic DNA Translation: COW49777.1
CVKR01000014 Genomic DNA Translation: CRF26637.1
CP044345 Genomic DNA Translation: QEX90704.1
QSXJ01001053 Genomic DNA Translation: REM62628.1
FPTZ01000013 Genomic DNA Translation: SGH83459.1
SRLJ01000066 Genomic DNA Translation: TGD70502.1

NCBI Reference Sequences

More...RefSeqi		WP_003414663.1, NZ_WUJD01000041.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AMC47338; AMC47338; RN05_3062
CFE49563; CFE49563; ERS007681_04689
CFE71404; CFE71404; ERS007688_03661
CFR76809; CFR76809; ERS007657_01511
CKP75539; CKP75539; ERS024213_02673
CKR03018; CKR03018; ERS027653_00529
CKR03790; CKR03790; ERS027652_00565
CKR30625; CKR30625; ERS027644_00944
CKR79603; CKR79603; ERS027661_02117
CKS89872; CKS89872; ERS027659_03706
CKT16735; CKT16735; ERS027666_02252
CKV27421; CKV27421; ERS031537_02393
CNH14037; CNH14037; ERS124361_02938
CNM60052; CNM60052; ERS023446_00771
CNU98426; CNU98426; ERS007665_01955
CNV01722; CNV01722; ERS007661_01511
CNV11363; CNV11363; ERS007670_02537
CNV33270; CNV33270; ERS007663_02936
CNY09853; CNY09853; ERS013471_00403
COV39064; COV39064; ERS007679_01749
COW13348; COW13348; ERS007703_02850
COW18867; COW18867; ERS007741_01761
COW33480; COW33480; ERS007722_02462
COW40150; COW40150; ERS007672_03685
COW49777; COW49777; ERS007720_02746
COW67801; COW67801; ERS007737_00187
COX79836; COX79836; ERS007726_02590
COY20867; COY20867; ERS007739_02260
COY58801; COY58801; ERS007731_03472
CRH11253; CRH11253; BN1303_00986
CRH12521; CRH12521; BN1213_01854

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23490877

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1773.206.peg.1536

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01001290 Genomic DNA Translation: CFE49563.1
CFOH01000844 Genomic DNA Translation: CFE71404.1
CGCX01000472 Genomic DNA Translation: CFR76809.1
CNFU01000421 Genomic DNA Translation: CKR79603.1
CNFT01001132 Genomic DNA Translation: CKS89872.1
CQAC01000013 Genomic DNA Translation: CNG71320.1
CQGE01000010 Genomic DNA Translation: CNM60052.1
CQPW01000368 Genomic DNA Translation: CNU98426.1
CQQC01000427 Genomic DNA Translation: CNV01722.1
CQPL01000556 Genomic DNA Translation: CNV11363.1
CQPV01000515 Genomic DNA Translation: CNV33270.1
CQTT01000006 Genomic DNA Translation: CNY09853.1
CSAD01000202 Genomic DNA Translation: COV39064.1
CSAE01000340 Genomic DNA Translation: COW13348.1
CHKL01000166 Genomic DNA Translation: COW18867.1
CSAM01000184 Genomic DNA Translation: COW33480.1
CSAJ01000376 Genomic DNA Translation: COW49777.1
CVKR01000014 Genomic DNA Translation: CRF26637.1
CP044345 Genomic DNA Translation: QEX90704.1
QSXJ01001053 Genomic DNA Translation: REM62628.1
FPTZ01000013 Genomic DNA Translation: SGH83459.1
SRLJ01000066 Genomic DNA Translation: TGD70502.1
RefSeqiWP_003414663.1, NZ_WUJD01000041.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC47338; AMC47338; RN05_3062
CFE49563; CFE49563; ERS007681_04689
CFE71404; CFE71404; ERS007688_03661
CFR76809; CFR76809; ERS007657_01511
CKP75539; CKP75539; ERS024213_02673
CKR03018; CKR03018; ERS027653_00529
CKR03790; CKR03790; ERS027652_00565
CKR30625; CKR30625; ERS027644_00944
CKR79603; CKR79603; ERS027661_02117
CKS89872; CKS89872; ERS027659_03706
CKT16735; CKT16735; ERS027666_02252
CKV27421; CKV27421; ERS031537_02393
CNH14037; CNH14037; ERS124361_02938
CNM60052; CNM60052; ERS023446_00771
CNU98426; CNU98426; ERS007665_01955
CNV01722; CNV01722; ERS007661_01511
CNV11363; CNV11363; ERS007670_02537
CNV33270; CNV33270; ERS007663_02936
CNY09853; CNY09853; ERS013471_00403
COV39064; COV39064; ERS007679_01749
COW13348; COW13348; ERS007703_02850
COW18867; COW18867; ERS007741_01761
COW33480; COW33480; ERS007722_02462
COW40150; COW40150; ERS007672_03685
COW49777; COW49777; ERS007720_02746
COW67801; COW67801; ERS007737_00187
COX79836; COX79836; ERS007726_02590
COY20867; COY20867; ERS007739_02260
COY58801; COY58801; ERS007731_03472
CRH11253; CRH11253; BN1303_00986
CRH12521; CRH12521; BN1213_01854
GeneIDi23490877
PATRICifig|1773.206.peg.1536

Family and domain databases

CDDicd00520, RRF, 1 hit
HAMAPiMF_00040, RRF, 1 hit
InterProiView protein in InterPro
IPR002661, Ribosome_recyc_fac
IPR023584, Ribosome_recyc_fac_dom
IPR036191, RRF_sf
PANTHERiPTHR20982, PTHR20982, 1 hit
PfamiView protein in Pfam
PF01765, RRF, 1 hit
SUPFAMiSSF55194, SSF55194, 1 hit
TIGRFAMsiTIGR00496, frr, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045K6P8_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045K6P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: December 2, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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