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Entry version 60 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein

Cell division protein SepF

Gene

sepF

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotationARBA annotation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTUB443150:G1H6J-2344-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division protein SepFUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sepFUniRule annotationImported
ORF Names:E5M52_15770Imported, ERS007663_03956Imported, ERS007665_02963Imported, ERS007670_01323Imported, ERS007679_00910Imported, ERS007681_01327Imported, ERS007703_02687Imported, ERS007722_01768Imported, ERS007741_01788Imported, ERS013471_02073Imported, ERS023446_02289Imported, ERS027646_02048Imported, ERS027659_02376Imported, ERS027661_01281Imported, ERS075361_03086Imported, ERS094182_01827Imported, F6W99_00742Imported, F9908_01045Imported, FRD82_10230Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000431688 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with FtsZ.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 81DisorderedSequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi24 – 63PolyampholyteSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SepF family.UniRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.110.150, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01197, SepF, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023052, Cell_div_SepF
IPR007561, Cell_div_SepF/SepF-rel
IPR038594, SepF-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR35798, PTHR35798, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04472, SepF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045JPV2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTLHKVKAY FGMAPMEDYD DEYYDDRAPS RGYARPRFDD DYGRYDGRDY
60 70 80 90 100
DDARSDSRGD LRGEPADYPP PGYRGGYADE PRFRPREFDR AEMTRPRFGS
110 120 130 140 150
WLRNSTRGAL AMDPRRMAMM FEDGHPLSKI TTLRPKDYSE ARTIGERFRD
160 170 180 190 200
GSPVIMDLVS MDNADAKRLV DFAAGLAFAL RGSFDKVATK VFLLSPADVD
210
VSPEERRRIA ETGFYAYQ
Length:218
Mass (Da):25,028
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE457753E15514EF8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000128 Genomic DNA Translation: CFE38956.1
CNFU01000203 Genomic DNA Translation: CKR42598.1
CNFT01000555 Genomic DNA Translation: CKR91140.1
CNGE01000348 Genomic DNA Translation: CKS54410.1
CQAC01000026 Genomic DNA Translation: CNH04363.1
CQGE01000048 Genomic DNA Translation: CNN14322.1
CQPL01000204 Genomic DNA Translation: CNU33931.1
CQPW01000720 Genomic DNA Translation: CNV43645.1
CQPV01000958 Genomic DNA Translation: CNV72922.1
CQTT01000051 Genomic DNA Translation: CNY59404.1
CSAD01000084 Genomic DNA Translation: COV04733.1
CSAE01000309 Genomic DNA Translation: COW07263.1
CSAM01000110 Genomic DNA Translation: COW12932.1
CHKL01000170 Genomic DNA Translation: COW19746.1
CVKR01000012 Genomic DNA Translation: CRF26389.1
WFKV01000001 Genomic DNA Translation: KAB7807639.1
CP044345 Genomic DNA Translation: QEX89967.1
SRLJ01000039 Genomic DNA Translation: TGD72927.1
VOOQ01000268 Genomic DNA Translation: TXB93475.1

NCBI Reference Sequences

More...
RefSeqi
WP_003411133.1, NZ_WUJD01000032.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC46571; AMC46571; RN05_2295
CFE38956; CFE38956; ERS007681_01327
CKR27669; CKR27669; ERS027656_00949
CKR30929; CKR30929; ERS027652_01120
CKR42598; CKR42598; ERS027661_01281
CKR76515; CKR76515; ERS027644_02038
CKR91140; CKR91140; ERS027659_02376
CKS54410; CKS54410; ERS027646_02048
CKV26541; CKV26541; ERS031537_02369
CNG97617; CNG97617; ERS124361_02479
CNN14322; CNN14322; ERS023446_02289
CNU33931; CNU33931; ERS007670_01323
CNV43645; CNV43645; ERS007665_02963
CNV72922; CNV72922; ERS007663_03956
CNY59404; CNY59404; ERS013471_02073
COV04733; COV04733; ERS007679_00910
COW07263; COW07263; ERS007703_02687
COW12932; COW12932; ERS007722_01768
COW19746; COW19746; ERS007741_01788

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23491661

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.1011

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000128 Genomic DNA Translation: CFE38956.1
CNFU01000203 Genomic DNA Translation: CKR42598.1
CNFT01000555 Genomic DNA Translation: CKR91140.1
CNGE01000348 Genomic DNA Translation: CKS54410.1
CQAC01000026 Genomic DNA Translation: CNH04363.1
CQGE01000048 Genomic DNA Translation: CNN14322.1
CQPL01000204 Genomic DNA Translation: CNU33931.1
CQPW01000720 Genomic DNA Translation: CNV43645.1
CQPV01000958 Genomic DNA Translation: CNV72922.1
CQTT01000051 Genomic DNA Translation: CNY59404.1
CSAD01000084 Genomic DNA Translation: COV04733.1
CSAE01000309 Genomic DNA Translation: COW07263.1
CSAM01000110 Genomic DNA Translation: COW12932.1
CHKL01000170 Genomic DNA Translation: COW19746.1
CVKR01000012 Genomic DNA Translation: CRF26389.1
WFKV01000001 Genomic DNA Translation: KAB7807639.1
CP044345 Genomic DNA Translation: QEX89967.1
SRLJ01000039 Genomic DNA Translation: TGD72927.1
VOOQ01000268 Genomic DNA Translation: TXB93475.1
RefSeqiWP_003411133.1, NZ_WUJD01000032.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC46571; AMC46571; RN05_2295
CFE38956; CFE38956; ERS007681_01327
CKR27669; CKR27669; ERS027656_00949
CKR30929; CKR30929; ERS027652_01120
CKR42598; CKR42598; ERS027661_01281
CKR76515; CKR76515; ERS027644_02038
CKR91140; CKR91140; ERS027659_02376
CKS54410; CKS54410; ERS027646_02048
CKV26541; CKV26541; ERS031537_02369
CNG97617; CNG97617; ERS124361_02479
CNN14322; CNN14322; ERS023446_02289
CNU33931; CNU33931; ERS007670_01323
CNV43645; CNV43645; ERS007665_02963
CNV72922; CNV72922; ERS007663_03956
CNY59404; CNY59404; ERS013471_02073
COV04733; COV04733; ERS007679_00910
COW07263; COW07263; ERS007703_02687
COW12932; COW12932; ERS007722_01768
COW19746; COW19746; ERS007741_01788
GeneIDi23491661
PATRICifig|1773.206.peg.1011

Enzyme and pathway databases

BioCyciMTUB443150:G1H6J-2344-MONOMER

Family and domain databases

Gene3Di3.30.110.150, 1 hit
HAMAPiMF_01197, SepF, 1 hit
InterProiView protein in InterPro
IPR023052, Cell_div_SepF
IPR007561, Cell_div_SepF/SepF-rel
IPR038594, SepF-like_sf
PANTHERiPTHR35798, PTHR35798, 1 hit
PfamiView protein in Pfam
PF04472, SepF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045JPV2_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045JPV2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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