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Entry version 67 (02 Jun 2021)
Sequence version 1 (09 Jul 2014)
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Protein

Carbamoyl-phosphate synthase large chain

Gene

carB

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes carbamoyl phosphate from bicarbonate.UniRule annotation This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes carbamoyl phosphate from bicarbonate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in the pathway UMP biosynthesis via de novo pathway, which is part of Pyrimidine metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-dihydroorotate from bicarbonate.UniRule annotationARBA annotation This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-dihydroorotate from bicarbonate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigaseUniRule annotationARBA annotation
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationARBA annotation, Pyrimidine biosynthesisUniRule annotationARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, ManganeseARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00068;UER00171
UPA00070
UPA00070;UER00115

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbamoyl-phosphate synthase large chainUniRule annotation (EC:6.3.5.5UniRule annotation)
Alternative name(s):
Carbamoyl-phosphate synthetase ammonia chainUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:carBUniRule annotationImported
ORF Names:C0094_07605Imported, E5M05_11525Imported, E5M52_08640Imported, E5M78_08635Imported, ERS007663_01749Imported, ERS013471_02459Imported, ERS094182_01036Imported, F6W99_04109Imported, GCL30_01035Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000047893 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000298278 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000235535 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000470375 Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 333ATP-graspInterPro annotationAdd BLAST196
Domaini693 – 884ATP-graspInterPro annotationAdd BLAST192
Domaini966 – 1113MGS-likeInterPro annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 407Carboxyphosphate synthetic domainUniRule annotationAdd BLAST407
Regioni966 – 1115Allosteric domainUniRule annotationAdd BLAST150

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CarB family.UniRule annotationARBA annotation

Keywords - Domaini

RepeatUniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01424, MGS_CPS_II, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1030.10, 1 hit
3.40.50.1380, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01210_B, CPSase_L_chain_B, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011761, ATP-grasp
IPR006275, CarbamoylP_synth_lsu
IPR005480, CarbamoylP_synth_lsu_oligo
IPR036897, CarbamoylP_synth_lsu_oligo_sf
IPR005479, CbamoylP_synth_lsu-like_ATP-bd
IPR005483, CbamoylP_synth_lsu_CPSase_dom
IPR011607, MGS-like_dom
IPR036914, MGS-like_dom_sf
IPR033937, MGS_CPS_CarB
IPR016185, PreATP-grasp_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02786, CPSase_L_D2, 2 hits
PF02787, CPSase_L_D3, 1 hit
PF02142, MGS, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00098, CPSASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01096, CPSase_L_D3, 1 hit
SM00851, MGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48108, SSF48108, 1 hit
SSF52335, SSF52335, 1 hit
SSF52440, SSF52440, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01369, CPSaseII_lrg, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975, ATP_GRASP, 2 hits
PS00866, CPSASE_1, 1 hit
PS00867, CPSASE_2, 2 hits
PS51855, MGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045J6W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRTDLHHV LVIGSGPIVI GQACEFDYSG TQACRVLRAE GLQVSLVNSN
60 70 80 90 100
PATIMTDPEF ADHTYVEPIT PAFVERVIAQ QAERGNKIDA LLATLGGQTA
110 120 130 140 150
LNTAVALYES GVLEKYGVEL IGADFDAIQR GEDRQRFKDI VAKAGGESAR
160 170 180 190 200
SRVCFTMAEV RETVAELGLP VVVRPSFTMG GLGSGIAYST DEVDRMAGAG
210 220 230 240 250
LAASPSANVL IEESIYGWKE FELELMRDGH DNVVVVCSIE NVDPMGVHTG
260 270 280 290 300
DSVTVAPAMT LTDREYQRMR DLGIAILREV GVDTGGCNIQ FAVNPRDGRL
310 320 330 340 350
IVIEMNPRVS RSSALASKAT GFPIAKIAAK LAIGYTLDEI VNDITGETPA
360 370 380 390 400
CFEPTLDYVV VKAPRFAFEK FPGADPTLTT TMKSVGEAMS LGRNFVEALG
410 420 430 440 450
KVMRSLETTR AGFWTAPDPD GGIEEALTRL RTPAEGRLYD IELALRLGAT
460 470 480 490 500
VERVAEASGV DPWFIAQINE LVNLRNELVA APVLNAELLR RAKHSGLSDH
510 520 530 540 550
QIASLRPELA GEAGVRSLRV RLGIHPVYKT VDTCAAEFEA QTPYHYSSYE
560 570 580 590 600
LDPAAETEVA PQTERPKVLI LGSGPNRIGQ GIEFDYSCVH AATTLSQAGF
610 620 630 640 650
ETVMVNCNPE TVSTDYDTAD RLYFEPLTFE DVLEVYHAEM ESGSGGPGVA
660 670 680 690 700
GVIVQLGGQT PLGLAHRLAD AGVPIVGTPP EAIDLAEDRG AFGDLLSAAG
710 720 730 740 750
LPAPKYGTAT TFAQARRIAE EIGYPVLVRP SYVLGGRGME IVYDEETLQG
760 770 780 790 800
YITRATQLSP EHPVLVDRFL EDAVEIDVDA LCDGAEVYIG GIMEHIEEAG
810 820 830 840 850
IHSGDSACAL PPVTLGRSDI AKVRKATEAI AHGIGVVGLL NVQYALKDDV
860 870 880 890 900
LYVLEANPRA SRTVPFVSKA TAVPLAKACA RIMLGATIAQ LRAEGLLAVT
910 920 930 940 950
GDGAHAARNA PIAVKEAVLP FHRFRRADGA AIDSLLGPEM KSTGEVMGID
960 970 980 990 1000
RDFGSAFAKS QTAAYGSLPA QGTVFVSVAN RDKRSLVFPV KRLADLGFRV
1010 1020 1030 1040 1050
LATEGTAEML RRNGIPCDDV RKHFEPAQPG RPTMSAVDAI RAGEVNMVIN
1060 1070 1080 1090 1100
TPYGNSGPRI DGYEIRSAAV AGNIPCITTV QGASAAVQGI EAGIRGDIGV
1110
RSLQELHRVI GGVER
Length:1,115
Mass (Da):118,961
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i293F6A35FDE05981
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP83045.1
CQPV01000229 Genomic DNA Translation: CNU74890.1
CQTT01000070 Genomic DNA Translation: CNY71707.1
CVKR01000006 Genomic DNA Translation: CRF25610.1
WFLD01000001 Genomic DNA Translation: KAB7842500.1
CP044345 Genomic DNA Translation: QEX93283.1
SRLJ01000016 Genomic DNA Translation: TGD77041.1
SRLK01000015 Genomic DNA Translation: TGD92345.1
SRLI01000021 Genomic DNA Translation: TGE03083.1

NCBI Reference Sequences

More...
RefSeqi
WP_003898855.1, NZ_WUJD01000014.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CKS61396; CKS61396; ERS027651_03175
CNG89832; CNG89832; ERS124361_02240
SGL98033; SGL98033; SAMEA2682864_01605

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP83045.1
CQPV01000229 Genomic DNA Translation: CNU74890.1
CQTT01000070 Genomic DNA Translation: CNY71707.1
CVKR01000006 Genomic DNA Translation: CRF25610.1
WFLD01000001 Genomic DNA Translation: KAB7842500.1
CP044345 Genomic DNA Translation: QEX93283.1
SRLJ01000016 Genomic DNA Translation: TGD77041.1
SRLK01000015 Genomic DNA Translation: TGD92345.1
SRLI01000021 Genomic DNA Translation: TGE03083.1
RefSeqiWP_003898855.1, NZ_WUJD01000014.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCKS61396; CKS61396; ERS027651_03175
CNG89832; CNG89832; ERS124361_02240
SGL98033; SGL98033; SAMEA2682864_01605

Enzyme and pathway databases

UniPathwayiUPA00068;UER00171
UPA00070
UPA00070;UER00115

Family and domain databases

CDDicd01424, MGS_CPS_II, 1 hit
Gene3Di1.10.1030.10, 1 hit
3.40.50.1380, 1 hit
HAMAPiMF_01210_B, CPSase_L_chain_B, 1 hit
InterProiView protein in InterPro
IPR011761, ATP-grasp
IPR006275, CarbamoylP_synth_lsu
IPR005480, CarbamoylP_synth_lsu_oligo
IPR036897, CarbamoylP_synth_lsu_oligo_sf
IPR005479, CbamoylP_synth_lsu-like_ATP-bd
IPR005483, CbamoylP_synth_lsu_CPSase_dom
IPR011607, MGS-like_dom
IPR036914, MGS-like_dom_sf
IPR033937, MGS_CPS_CarB
IPR016185, PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF02786, CPSase_L_D2, 2 hits
PF02787, CPSase_L_D3, 1 hit
PF02142, MGS, 1 hit
PRINTSiPR00098, CPSASE
SMARTiView protein in SMART
SM01096, CPSase_L_D3, 1 hit
SM00851, MGS, 1 hit
SUPFAMiSSF48108, SSF48108, 1 hit
SSF52335, SSF52335, 1 hit
SSF52440, SSF52440, 2 hits
TIGRFAMsiTIGR01369, CPSaseII_lrg, 1 hit
PROSITEiView protein in PROSITE
PS50975, ATP_GRASP, 2 hits
PS00866, CPSASE_1, 1 hit
PS00867, CPSASE_2, 2 hits
PS51855, MGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045J6W7_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045J6W7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 2, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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