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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotationImported
Synonyms:argS_1Imported
ORF Names:ERS007663_01494Imported, ERS007670_00638Imported, ERS007681_00050Imported, ERS007688_00795Imported, ERS023446_01608Imported, ERS024276_00016Imported, ERS027646_00454Imported, ERS027651_01641Imported, ERS027653_00429Imported, ERS027656_01309Imported, ERS124361_00754Imported, SAMEA2683035_01556Imported
OrganismiMycobacterium tuberculosisImported
Taxonomic identifieri1773 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000050143 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000049114 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

SMRiA0A045J3G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 93Arg_tRNA_synt_NInterPro annotationAdd BLAST90
Domaini429 – 550DALR_1InterPro annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 140"HIGH" regionUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A0A045J3G9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPADLAELL KATAAAVLAE RGLDASALPQ MVTVERPRIP EHGDYASNLA
60 70 80 90 100
MQLAKKVGTN PRELAGWLAE ALTKVDGIAS AEVAGPGFIN MRLETAAQAK
110 120 130 140 150
VVTSVIDAGH SYGHSLLLAG RKVNLEFVSA NPTGPIHIGG TRWAAVGDAL
160 170 180 190 200
GRLLTTQGAD VVREYYFNDH GAQIDRFANS LIAAAKGEPT PQDGYAGSYI
210 220 230 240 250
TNIAEQVLQK APDALSLPDA ELRETFRAIG VDLMFDHIKQ SLHEFGTDFD
260 270 280 290 300
VYTHEDSMHT GGRVENAIAR LRETGNIYEK DGATWLRTSA FGDDKDRVVI
310 320 330 340 350
KSDGKPAYIA GDLAYYLDKR QRGFDLCIYM LGADHHGYIA RLKAAAAAFG
360 370 380 390 400
DDPATVEVLI GQMVNLVRDG QPVRMSKRAG TVLTLDDLVE AIGVDAARYS
410 420 430 440 450
LIRSSVDTAI DIDLALWSSA SNENPVYYVQ YAHARLSALA RNAAELALIP
460 470 480 490 500
DTNHLELLNH DKEGTLLRTL GEFPRVLETA ASLREPHRVC RYLEDLAGDY
510 520 530 540 550
HRFYDSCRVL PQGDEQPTDL HTARLALCQA TRQVIANGLA IIGVTAPERM
Length:550
Mass (Da):59,709
Last modified:July 9, 2014 - v1
Checksum:i4F11239A6238124D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000003 Genomic DNA Translation: CFE34362.1
CFOH01000083 Genomic DNA Translation: CFE47581.1
CNCN01000002 Genomic DNA Translation: CKN63122.1
CNFS01000056 Genomic DNA Translation: CKQ97323.1
CNFV01000164 Genomic DNA Translation: CKR45333.1
CNGE01000045 Genomic DNA Translation: CKR69968.1
CIEA01000013 Genomic DNA Translation: CKR87502.1
CHDS01000007 Genomic DNA Translation: CNG34748.1
CQGE01000027 Genomic DNA Translation: CNM91832.1
CQPL01000084 Genomic DNA Translation: CNT99297.1
CQPV01000185 Genomic DNA Translation: CNU59427.1
FPTZ01000008 Genomic DNA Translation: SGH59919.1
RefSeqiWP_003406630.1, NZ_PYQC01000072.1

Genome annotation databases

EnsemblBacteriaiAMC45658; AMC45658; RN05_1382
CFE34362; CFE34362; ERS007681_00050
CFE47581; CFE47581; ERS007688_00795
CKN63122; CKN63122; ERS024276_00016
CKQ97323; CKQ97323; ERS027653_00429
CKR45333; CKR45333; ERS027656_01309
CKR69968; CKR69968; ERS027646_00454
CNG34748; CNG34748; ERS124361_00754
CNM91832; CNM91832; ERS023446_01608
CNT99297; CNT99297; ERS007670_00638
CNU59427; CNU59427; ERS007663_01494
CNY20383; CNY20383; ERS013471_00796
PATRICifig|1773.211.peg.651

Similar proteinsi

Entry informationi

Entry nameiA0A045J3G9_MYCTX
AccessioniPrimary (citable) accession number: A0A045J3G9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 12, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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