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Entry version 66 (02 Jun 2021)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

16S rRNA m5C967 methyltransferase

Gene

fmu

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei301S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei325S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei341S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei394NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationARBA annotation, RNA-bindingPROSITE-ProRule annotationARBA annotation, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
16S rRNA m5C967 methyltransferaseImported
Submitted name:
FMU protein (SUN protein)Imported (EC:2.1.1.176Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fmuImported
ORF Names:C0094_07725Imported, DSI38_12960Imported, E5M05_11405Imported, E5M52_08760Imported, E5M78_08515Imported, ERS007741_02047Imported, ERS013471_03245Imported, ERS023446_03375Imported, ERS024276_00254Imported, ERS094182_01013Imported, F6W99_04132Imported, FRD82_16525Imported, GCL30_00915Imported, SAMEA2683035_01114Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000470375 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000298278 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000235535 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini174 – 456SAM_MT_RSMB_NOPInterPro annotationAdd BLAST283

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni276 – 282S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.PROSITE-ProRule annotationARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.940.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR035926, NusB-like_sf
IPR006027, NusB_RsmB_TIM44
IPR023267, RCMT
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01189, Methyltr_RsmB-F, 1 hit
PF01029, NusB, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02008, RCMTFAMILY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48013, SSF48013, 1 hit
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045J0E8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPRSRGPRR RPLDPARRAA FETLRAVSAR DAYANLVLPA LLAQRGIGGR
60 70 80 90 100
DAAFATELTY GTCRARGLLD AVIGAAAERS PQAIDPVLLD LLRLGTYQLL
110 120 130 140 150
RTRVDAHAAV STTVEQAGIE FDSARAGFVN GVLRTIAGRD ERSWVGELAP
160 170 180 190 200
DAQNDPIGHA AFVHAHPRWI AQAFADALGA AVGELEAVLA SDDERPAVHL
210 220 230 240 250
AARPGVLTAG ELARAVRGTV GRYSPFAVYL PRGDPGRLAP VRDGQALVQD
260 270 280 290 300
EGSQLVARAL TLAPVDGDTG RWLDLCAGPG GKTALLAGLG LQCAARVTAV
310 320 330 340 350
EPSPHRADLV AQNTRGLPVE LLRVDGRHTD LDPGFDRVLV DAPCTGLGAL
360 370 380 390 400
RRRPEARWRR QPADVAALAK LQRELLSAAI ALTRPGGVVL YATCSPHLAE
410 420 430 440 450
TVGAVADALR RHPVHALDTR PLFEPVIAGL GEGPHVQLWP HRHGTDAMFA

AALRRLT
Length:457
Mass (Da):48,493
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA90DEFCDBABA8C4D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP83065.1
CNCN01000031 Genomic DNA Translation: CKN71779.1
CQGE01000103 Genomic DNA Translation: CNN42204.1
CQTT01000117 Genomic DNA Translation: CNY98629.1
CHKL01000210 Genomic DNA Translation: COW27788.1
CVKR01000006 Genomic DNA Translation: CRF25588.1
WFLD01000001 Genomic DNA Translation: KAB7842479.1
CP044345 Genomic DNA Translation: QEX93305.1
QSXJ01000880 Genomic DNA Translation: REM67092.1
FPTZ01000005 Genomic DNA Translation: SGH42349.1
SRLJ01000016 Genomic DNA Translation: TGD77062.1
SRLK01000015 Genomic DNA Translation: TGD92324.1
SRLI01000021 Genomic DNA Translation: TGE03063.1
VOOQ01000566 Genomic DNA Translation: TXB92304.1

NCBI Reference Sequences

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RefSeqi
WP_003898865.1, NZ_WUJD01000014.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CKQ92940; CKQ92940; ERS027656_00253
CKS10661; CKS10661; ERS027653_02574
CKS46684; CKS46684; ERS027651_02862
CKS50376; CKS50376; ERS027644_03117
CNH41107; CNH41107; ERS124361_03594
CNN42204; CNN42204; ERS023446_03375
COW27788; COW27788; ERS007741_02047
REM95788; REM95788; DSI35_28365
SGH42349; SGH42349; SAMEA2683035_01114
SGL97105; SGL97105; SAMEA2682864_01581

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.1173

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP83065.1
CNCN01000031 Genomic DNA Translation: CKN71779.1
CQGE01000103 Genomic DNA Translation: CNN42204.1
CQTT01000117 Genomic DNA Translation: CNY98629.1
CHKL01000210 Genomic DNA Translation: COW27788.1
CVKR01000006 Genomic DNA Translation: CRF25588.1
WFLD01000001 Genomic DNA Translation: KAB7842479.1
CP044345 Genomic DNA Translation: QEX93305.1
QSXJ01000880 Genomic DNA Translation: REM67092.1
FPTZ01000005 Genomic DNA Translation: SGH42349.1
SRLJ01000016 Genomic DNA Translation: TGD77062.1
SRLK01000015 Genomic DNA Translation: TGD92324.1
SRLI01000021 Genomic DNA Translation: TGE03063.1
VOOQ01000566 Genomic DNA Translation: TXB92304.1
RefSeqiWP_003898865.1, NZ_WUJD01000014.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCKQ92940; CKQ92940; ERS027656_00253
CKS10661; CKS10661; ERS027653_02574
CKS46684; CKS46684; ERS027651_02862
CKS50376; CKS50376; ERS027644_03117
CNH41107; CNH41107; ERS124361_03594
CNN42204; CNN42204; ERS023446_03375
COW27788; COW27788; ERS007741_02047
REM95788; REM95788; DSI35_28365
SGH42349; SGH42349; SAMEA2683035_01114
SGL97105; SGL97105; SAMEA2682864_01581
PATRICifig|1773.206.peg.1173

Family and domain databases

Gene3Di1.10.940.10, 1 hit
InterProiView protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR035926, NusB-like_sf
IPR006027, NusB_RsmB_TIM44
IPR023267, RCMT
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF01189, Methyltr_RsmB-F, 1 hit
PF01029, NusB, 1 hit
PRINTSiPR02008, RCMTFAMILY
SUPFAMiSSF48013, SSF48013, 1 hit
SSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045J0E8_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045J0E8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 2, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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