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Entry version 57 (11 Dec 2019)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Cytochrome P450

Gene

cyp123

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenaseUniRule annotationSAAS annotation, Oxidoreductase
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cytochrome P450Imported (EC:1.14.-.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cyp123Imported
ORF Names:ERS023446_03544Imported, ERS027651_02746Imported, SAMEA2683035_02981Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000039953 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG4106A3M Bacteria
COG2124 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001128 Cyt_P450
IPR002397 Cyt_P450_B
IPR017972 Cyt_P450_CS
IPR036396 Cyt_P450_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00067 p450, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00359 BP450
PR00385 P450

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48264 SSF48264, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045IR45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTVRVGDPEL VLDPYDYDFH EDPYPYYRRL RDEAPLYRNE ERNFWAVSRH
60 70 80 90 100
HDVLQGFRDS TALSNAYGVS LDPSSRTSEA YRVMSMLAMD DPAHLRMRTL
110 120 130 140 150
VSKGFTPRRI RELEPQVLEL ARIHLDSALQ TESFDFVAEF AGKLPMDVIS
160 170 180 190 200
ELIGVPDTDR ARIRALADAV LHREDGVADV PPPAMAASIE LMRYYADLIA
210 220 230 240 250
EFRRRPANNL TSALLAAELD GDRLSDQEIM AFLFLMVIAG NETTTKLLAN
260 270 280 290 300
AVYWAAHHPG QLARVFADHS RIPMWVEETL RYDTSSQILA RTVAHDLTLY
310 320 330 340 350
DTTIPEGEVL LLLPGSANRD DRVFDDPDDY RIGREIGCKL VSFGSGAHFC
360 370 380 390 400
LGAHLARMEA RVALGALLRR IRNYEVDDDN VVRVHSSNVR GFAHLPISVQ

AR
Length:402
Mass (Da):45,421
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76AD843019361798
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CIEA01000030 Genomic DNA Translation: CKS40600.1
CQGE01000117 Genomic DNA Translation: CNN46181.1
FPTZ01000023 Genomic DNA Translation: SGI16639.1

NCBI Reference Sequences

More...
RefSeqi
WP_003403911.1, NZ_VOVY01000031.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC45093; AMC45093; RN05_0817
CFE34431; CFE34431; ERS007681_00063
CFE47031; CFE47031; ERS007688_00569
CKO29430; CKO29430; ERS024213_00213
CKQ82447; CKQ82447; ERS027654_00129
CKQ85408; CKQ85408; ERS027656_00104
CKQ96072; CKQ96072; ERS027644_00223
CKR28146; CKR28146; ERS027661_00933
CKS95745; CKS95745; ERS027652_03881
CKT55613; CKT55613; ERS027646_03794
CKT82272; CKT82272; ERS027666_03453
CKU32386; CKU32386; ERS031537_00294
CNG82246; CNG82246; ERS124361_01988
CNN46181; CNN46181; ERS023446_03544
CNU04593; CNU04593; ERS007665_00285
CNV34071; CNV34071; ERS007670_03003
CNY52479; CNY52479; ERS013471_01852
COV34129; COV34129; ERS007679_01642
COV49832; COV49832; ERS007720_00350
COV57201; COV57201; ERS007722_00346
CRH15086; CRH15086; BN1303_02977
CRH15779; CRH15779; BN1213_03487

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.1263

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CIEA01000030 Genomic DNA Translation: CKS40600.1
CQGE01000117 Genomic DNA Translation: CNN46181.1
FPTZ01000023 Genomic DNA Translation: SGI16639.1
RefSeqiWP_003403911.1, NZ_VOVY01000031.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC45093; AMC45093; RN05_0817
CFE34431; CFE34431; ERS007681_00063
CFE47031; CFE47031; ERS007688_00569
CKO29430; CKO29430; ERS024213_00213
CKQ82447; CKQ82447; ERS027654_00129
CKQ85408; CKQ85408; ERS027656_00104
CKQ96072; CKQ96072; ERS027644_00223
CKR28146; CKR28146; ERS027661_00933
CKS95745; CKS95745; ERS027652_03881
CKT55613; CKT55613; ERS027646_03794
CKT82272; CKT82272; ERS027666_03453
CKU32386; CKU32386; ERS031537_00294
CNG82246; CNG82246; ERS124361_01988
CNN46181; CNN46181; ERS023446_03544
CNU04593; CNU04593; ERS007665_00285
CNV34071; CNV34071; ERS007670_03003
CNY52479; CNY52479; ERS013471_01852
COV34129; COV34129; ERS007679_01642
COV49832; COV49832; ERS007720_00350
COV57201; COV57201; ERS007722_00346
CRH15086; CRH15086; BN1303_02977
CRH15779; CRH15779; BN1213_03487
PATRICifig|1773.211.peg.1263

Phylogenomic databases

eggNOGiENOG4106A3M Bacteria
COG2124 LUCA

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR002397 Cyt_P450_B
IPR017972 Cyt_P450_CS
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00359 BP450
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045IR45_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045IR45
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: December 11, 2019
This is version 57 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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