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Entry version 63 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Mycofactocin biosynthesis transcriptional regulator MftR

Gene

mftR

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi35 – 54H-T-H motifPROSITE-ProRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mycofactocin biosynthesis transcriptional regulator MftRImported
Submitted name:
Mycofactocin system transcriptional regulatorImported
Submitted name:
TetR family transcriptional regulatorImported
Submitted name:
Transcriptional regulatory proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mftRImported
ORF Names:DSI38_24830Imported, ERS007657_01951Imported, ERS007661_00558Imported, ERS007663_03275Imported, ERS007665_01657Imported, ERS007670_02023Imported, ERS007679_02465Imported, ERS007681_02443Imported, ERS007688_03081Imported, ERS007703_03930Imported, ERS007720_01439Imported, ERS007722_02681Imported, ERS013471_00598Imported, ERS023446_00434Imported, ERS024276_03118Imported, ERS027646_03153Imported, ERS027659_02490Imported, ERS027661_00544Imported, ERS075361_00788Imported, ERS094182_01316Imported, F6W99_03366Imported, F9908_03420Imported, FRD82_01395Imported, SAMEA2683035_02499Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000041288 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000321489 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000431688 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 72HTH tetR-typeInterPro annotationAdd BLAST61

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001647, HTH_TetR
IPR041347, MftR_C
IPR023851, Tscrpt_reg_TetR-type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17754, TetR_C_14, 1 hit
PF00440, TetR_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00455, HTHTETR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03968, mycofact_TetR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50977, HTH_TETR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045IQX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHESRVGRR RSTTPHHISD VAIELFAAHG FTDVSVDDIA RAAGIARRTL
60 70 80 90 100
FRYYASKNAI PWGDFSTHLA QLQGLLDNID SRIQLRDALR AALLAFNTFD
110 120 130 140 150
ESETIRHRKR MRVILQTPEL QAYSMTMYAG WREVIAKFVA RRSGGKTTDF
160 170 180 190
MPQTVAWTML GVALSAYEHW LRDESVSLTE ALGAAFDVVG AGLDRLNQ
Length:198
Mass (Da):22,264
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0167B32FB5687C2A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000322 Genomic DNA Translation: CFE40257.1
CFOH01000608 Genomic DNA Translation: CFE62910.1
CGCX01000681 Genomic DNA Translation: CFR81583.1
CNCN01000998 Genomic DNA Translation: CKP62372.1
CNFU01000067 Genomic DNA Translation: CKR07053.1
CNFT01000600 Genomic DNA Translation: CKR99378.1
CNGE01000690 Genomic DNA Translation: CKT20616.1
CQAC01000004 Genomic DNA Translation: CNG23077.1
CQGE01000005 Genomic DNA Translation: CNM47297.1
CQQC01000115 Genomic DNA Translation: CNU37180.1
CQPL01000381 Genomic DNA Translation: CNU78369.1
CQPW01000287 Genomic DNA Translation: CNU80434.1
CQPV01000627 Genomic DNA Translation: CNV43273.1
CQTT01000009 Genomic DNA Translation: CNY15001.1
CSAD01000342 Genomic DNA Translation: COV79058.1
CSAJ01000144 Genomic DNA Translation: COW01906.1
CSAM01000215 Genomic DNA Translation: COW40923.1
CSAE01000603 Genomic DNA Translation: COW61295.1
CVKR01000008 Genomic DNA Translation: CRF25886.1
WFKV01000003 Genomic DNA Translation: KAB7806472.1
CP044345 Genomic DNA Translation: QEX92555.1
QSXJ01001105 Genomic DNA Translation: REM59939.1
FPTZ01000017 Genomic DNA Translation: SGH98208.1
VOOQ01000022 Genomic DNA Translation: TXB95152.1

NCBI Reference Sequences

More...
RefSeqi
WP_003403482.1, NZ_WUJD01000006.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC45012; AMC45012; RN05_0736
CFE40257; CFE40257; ERS007681_02443
CFE62910; CFE62910; ERS007688_03081
CFR81583; CFR81583; ERS007657_01951
CFS29658; CFS29658; ERS007734_00191
CKP62372; CKP62372; ERS024276_03118
CKQ76433; CKQ76433; ERS027654_00007
CKQ93245; CKQ93245; ERS027644_00166
CKR07053; CKR07053; ERS027661_00544
CKR23151; CKR23151; ERS027656_00854
CKR79632; CKR79632; ERS027652_02253
CKR99378; CKR99378; ERS027659_02490
CKS18496; CKS18496; ERS027653_02681
CKT20616; CKT20616; ERS027646_03153
CKT71368; CKT71368; ERS027666_03305
CKV54838; CKV54838; ERS031537_02946
CNG73377; CNG73377; ERS124361_01718
CNM47297; CNM47297; ERS023446_00434
CNU37180; CNU37180; ERS007661_00558
CNU78369; CNU78369; ERS007670_02023
CNU80434; CNU80434; ERS007665_01657
CNV43273; CNV43273; ERS007663_03275
CNY15001; CNY15001; ERS013471_00598
COV79058; COV79058; ERS007679_02465
COW01906; COW01906; ERS007720_01439
COW40923; COW40923; ERS007722_02681
COW61295; COW61295; ERS007703_03930
COW87324; COW87324; ERS007672_04342
COX05034; COX05034; ERS007726_01657
COX41403; COX41403; ERS007731_01980
CRH15949; CRH15949; BN1213_03564
CRH16900; CRH16900; BN1303_03906

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23493200

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.977

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000322 Genomic DNA Translation: CFE40257.1
CFOH01000608 Genomic DNA Translation: CFE62910.1
CGCX01000681 Genomic DNA Translation: CFR81583.1
CNCN01000998 Genomic DNA Translation: CKP62372.1
CNFU01000067 Genomic DNA Translation: CKR07053.1
CNFT01000600 Genomic DNA Translation: CKR99378.1
CNGE01000690 Genomic DNA Translation: CKT20616.1
CQAC01000004 Genomic DNA Translation: CNG23077.1
CQGE01000005 Genomic DNA Translation: CNM47297.1
CQQC01000115 Genomic DNA Translation: CNU37180.1
CQPL01000381 Genomic DNA Translation: CNU78369.1
CQPW01000287 Genomic DNA Translation: CNU80434.1
CQPV01000627 Genomic DNA Translation: CNV43273.1
CQTT01000009 Genomic DNA Translation: CNY15001.1
CSAD01000342 Genomic DNA Translation: COV79058.1
CSAJ01000144 Genomic DNA Translation: COW01906.1
CSAM01000215 Genomic DNA Translation: COW40923.1
CSAE01000603 Genomic DNA Translation: COW61295.1
CVKR01000008 Genomic DNA Translation: CRF25886.1
WFKV01000003 Genomic DNA Translation: KAB7806472.1
CP044345 Genomic DNA Translation: QEX92555.1
QSXJ01001105 Genomic DNA Translation: REM59939.1
FPTZ01000017 Genomic DNA Translation: SGH98208.1
VOOQ01000022 Genomic DNA Translation: TXB95152.1
RefSeqiWP_003403482.1, NZ_WUJD01000006.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC45012; AMC45012; RN05_0736
CFE40257; CFE40257; ERS007681_02443
CFE62910; CFE62910; ERS007688_03081
CFR81583; CFR81583; ERS007657_01951
CFS29658; CFS29658; ERS007734_00191
CKP62372; CKP62372; ERS024276_03118
CKQ76433; CKQ76433; ERS027654_00007
CKQ93245; CKQ93245; ERS027644_00166
CKR07053; CKR07053; ERS027661_00544
CKR23151; CKR23151; ERS027656_00854
CKR79632; CKR79632; ERS027652_02253
CKR99378; CKR99378; ERS027659_02490
CKS18496; CKS18496; ERS027653_02681
CKT20616; CKT20616; ERS027646_03153
CKT71368; CKT71368; ERS027666_03305
CKV54838; CKV54838; ERS031537_02946
CNG73377; CNG73377; ERS124361_01718
CNM47297; CNM47297; ERS023446_00434
CNU37180; CNU37180; ERS007661_00558
CNU78369; CNU78369; ERS007670_02023
CNU80434; CNU80434; ERS007665_01657
CNV43273; CNV43273; ERS007663_03275
CNY15001; CNY15001; ERS013471_00598
COV79058; COV79058; ERS007679_02465
COW01906; COW01906; ERS007720_01439
COW40923; COW40923; ERS007722_02681
COW61295; COW61295; ERS007703_03930
COW87324; COW87324; ERS007672_04342
COX05034; COX05034; ERS007726_01657
COX41403; COX41403; ERS007731_01980
CRH15949; CRH15949; BN1213_03564
CRH16900; CRH16900; BN1303_03906
GeneIDi23493200
PATRICifig|1773.211.peg.977

Family and domain databases

InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001647, HTH_TetR
IPR041347, MftR_C
IPR023851, Tscrpt_reg_TetR-type
PfamiView protein in Pfam
PF17754, TetR_C_14, 1 hit
PF00440, TetR_N, 1 hit
PRINTSiPR00455, HTHTETR
SUPFAMiSSF46689, SSF46689, 1 hit
TIGRFAMsiTIGR03968, mycofact_TetR, 1 hit
PROSITEiView protein in PROSITE
PS50977, HTH_TETR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045IQX9_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045IQX9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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