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Entry version 59 (17 Jun 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

AbrB/MazE/SpoVT family DNA-binding domain-containing protein

Gene

vapB27

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AbrB/MazE/SpoVT family DNA-binding domain-containing proteinImported
Submitted name:
Antitoxin VapB27Imported
Submitted name:
Conserved protein of uncharacterized function, putative antitoxinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vapB27Imported
ORF Names:AYJ03_003140Imported, DSI38_24300Imported, E5M05_09210Imported, ERS007657_01235Imported, ERS007665_01266Imported, ERS007670_02315Imported, ERS007679_00727Imported, ERS007681_01710Imported, ERS007688_00294Imported, ERS007703_03244Imported, ERS007720_01926Imported, ERS007722_02659Imported, ERS007741_02184Imported, ERS013471_02025Imported, ERS023446_02524Imported, ERS024276_02138Imported, ERS027646_03607Imported, ERS027659_03352Imported, ERS027661_02054Imported, ERS075361_00889Imported, ERS094182_01416Imported, F6W99_03267Imported, FRD82_16895Imported, GJE03_03140Imported, SAMEA2683035_02028Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000041288 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000388593 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000321489 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000075723 Componenti: Chromosome
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 45SpoVT-AbrBInterPro annotationAdd BLAST45

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2002 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007159 SpoVT-AbrB_dom
IPR037914 SpoVT-AbrB_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04014 MazE_antitoxin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00966 SpoVT_AbrB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF89447 SSF89447, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01439 lp_hng_hel_AbrB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51740 SPOVT_ABRB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045IPP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAVVDAAGR IVVPKPLREA LGLQPGSTVE ISRYGAGLHL IPTGRTARLE
60 70
EENGVLVATG ETTIDDEVVF GLIDSGRK
Length:78
Mass (Da):8,212
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10D8C631953A6B73
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000185 Genomic DNA Translation: CFE39330.1
CFOH01000025 Genomic DNA Translation: CFE46618.1
CGCX01000358 Genomic DNA Translation: CFR73956.1
CNCN01000523 Genomic DNA Translation: CKO87376.1
CNFU01000402 Genomic DNA Translation: CKR76113.1
CNFT01000954 Genomic DNA Translation: CKS62166.1
CNGE01000876 Genomic DNA Translation: CKT45572.1
CQAC01000004 Genomic DNA Translation: CNG26590.1
CQGE01000058 Genomic DNA Translation: CNN21147.1
CQPW01000192 Genomic DNA Translation: CNU54482.1
CQPL01000476 Genomic DNA Translation: CNU97788.1
CQTT01000050 Genomic DNA Translation: CNY58019.1
CSAD01000063 Genomic DNA Translation: COU96213.1
CSAJ01000218 Genomic DNA Translation: COW17973.1
CSAE01000423 Genomic DNA Translation: COW27357.1
CHKL01000233 Genomic DNA Translation: COW32257.1
CSAM01000212 Genomic DNA Translation: COW40000.1
CVKR01000008 Genomic DNA Translation: CRF25982.1
CP044345 Genomic DNA Translation: QEX92459.1
CP045962 Genomic DNA Translation: QGK77902.1
CP046529 Genomic DNA Translation: QGV20345.1
QSXJ01001105 Genomic DNA Translation: REM59851.1
FPTZ01000012 Genomic DNA Translation: SGH79392.1
SRLI01000016 Genomic DNA Translation: TGE03968.1
VOOQ01000590 Genomic DNA Translation: TXB92235.1

NCBI Reference Sequences

More...
RefSeqi
WP_003403139.1, NZ_WJSJ01000002.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC44915; AMC44915; RN05_0639
CFE39330; CFE39330; ERS007681_01710
CFE46618; CFE46618; ERS007688_00294
CFR73956; CFR73956; ERS007657_01235
CKO87376; CKO87376; ERS024276_02138
CKP11466; CKP11466; ERS024213_01513
CKR64808; CKR64808; ERS027652_01952
CKR76113; CKR76113; ERS027661_02054
CKS50571; CKS50571; ERS027654_03347
CKS62166; CKS62166; ERS027659_03352
CKT28880; CKT28880; ERS027666_02487
CKT45572; CKT45572; ERS027646_03607
CKU07696; CKU07696; ERS027656_04966
CKU28983; CKU28983; ERS031537_00220
CKU53234; CKU53234; ERS027653_05087
CNG37139; CNG37139; ERS124361_00798
CNN21147; CNN21147; ERS023446_02524
CNU54482; CNU54482; ERS007665_01266
CNU97788; CNU97788; ERS007670_02315
CNY58019; CNY58019; ERS013471_02025
COU96213; COU96213; ERS007679_00727
COW17973; COW17973; ERS007720_01926
COW27357; COW27357; ERS007703_03244
COW32257; COW32257; ERS007741_02184
COW40000; COW40000; ERS007722_02659
COY98706; COY98706; ERS007733_01357
COZ29564; COZ29564; ERS007731_04140
CRH13596; CRH13596; BN1213_02389
CRH15353; CRH15353; BN1303_03105

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.821

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000185 Genomic DNA Translation: CFE39330.1
CFOH01000025 Genomic DNA Translation: CFE46618.1
CGCX01000358 Genomic DNA Translation: CFR73956.1
CNCN01000523 Genomic DNA Translation: CKO87376.1
CNFU01000402 Genomic DNA Translation: CKR76113.1
CNFT01000954 Genomic DNA Translation: CKS62166.1
CNGE01000876 Genomic DNA Translation: CKT45572.1
CQAC01000004 Genomic DNA Translation: CNG26590.1
CQGE01000058 Genomic DNA Translation: CNN21147.1
CQPW01000192 Genomic DNA Translation: CNU54482.1
CQPL01000476 Genomic DNA Translation: CNU97788.1
CQTT01000050 Genomic DNA Translation: CNY58019.1
CSAD01000063 Genomic DNA Translation: COU96213.1
CSAJ01000218 Genomic DNA Translation: COW17973.1
CSAE01000423 Genomic DNA Translation: COW27357.1
CHKL01000233 Genomic DNA Translation: COW32257.1
CSAM01000212 Genomic DNA Translation: COW40000.1
CVKR01000008 Genomic DNA Translation: CRF25982.1
CP044345 Genomic DNA Translation: QEX92459.1
CP045962 Genomic DNA Translation: QGK77902.1
CP046529 Genomic DNA Translation: QGV20345.1
QSXJ01001105 Genomic DNA Translation: REM59851.1
FPTZ01000012 Genomic DNA Translation: SGH79392.1
SRLI01000016 Genomic DNA Translation: TGE03968.1
VOOQ01000590 Genomic DNA Translation: TXB92235.1
RefSeqiWP_003403139.1, NZ_WJSJ01000002.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC44915; AMC44915; RN05_0639
CFE39330; CFE39330; ERS007681_01710
CFE46618; CFE46618; ERS007688_00294
CFR73956; CFR73956; ERS007657_01235
CKO87376; CKO87376; ERS024276_02138
CKP11466; CKP11466; ERS024213_01513
CKR64808; CKR64808; ERS027652_01952
CKR76113; CKR76113; ERS027661_02054
CKS50571; CKS50571; ERS027654_03347
CKS62166; CKS62166; ERS027659_03352
CKT28880; CKT28880; ERS027666_02487
CKT45572; CKT45572; ERS027646_03607
CKU07696; CKU07696; ERS027656_04966
CKU28983; CKU28983; ERS031537_00220
CKU53234; CKU53234; ERS027653_05087
CNG37139; CNG37139; ERS124361_00798
CNN21147; CNN21147; ERS023446_02524
CNU54482; CNU54482; ERS007665_01266
CNU97788; CNU97788; ERS007670_02315
CNY58019; CNY58019; ERS013471_02025
COU96213; COU96213; ERS007679_00727
COW17973; COW17973; ERS007720_01926
COW27357; COW27357; ERS007703_03244
COW32257; COW32257; ERS007741_02184
COW40000; COW40000; ERS007722_02659
COY98706; COY98706; ERS007733_01357
COZ29564; COZ29564; ERS007731_04140
CRH13596; CRH13596; BN1213_02389
CRH15353; CRH15353; BN1303_03105
PATRICifig|1773.211.peg.821

Phylogenomic databases

eggNOGiCOG2002 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR007159 SpoVT-AbrB_dom
IPR037914 SpoVT-AbrB_sf
PfamiView protein in Pfam
PF04014 MazE_antitoxin, 1 hit
SMARTiView protein in SMART
SM00966 SpoVT_AbrB, 1 hit
SUPFAMiSSF89447 SSF89447, 1 hit
TIGRFAMsiTIGR01439 lp_hng_hel_AbrB, 1 hit
PROSITEiView protein in PROSITE
PS51740 SPOVT_ABRB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045IPP8_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045IPP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 17, 2020
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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