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Entry version 55 (11 Dec 2019)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Sulfolipid-1 RND transporter MmpL8

Gene

mmpL8

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sulfolipid-1 RND transporter MmpL8Imported
Submitted name:
Transporter MMPL8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mmpL8Imported
Synonyms:mmpL8_1Imported, mmpL8_4Imported, mmpL8_5Imported
ORF Names:ERS023446_01459Imported, ERS027651_02771Imported, EZX46_10840Imported, FDK60_11625Imported, FDK62_08915Imported, SAMEA2683035_00026Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000306581 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000298273 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000305204 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei43 – 61HelicalSequence analysisAdd BLAST19
Transmembranei218 – 235HelicalSequence analysisAdd BLAST18
Transmembranei241 – 269HelicalSequence analysisAdd BLAST29
Transmembranei319 – 342HelicalSequence analysisAdd BLAST24
Transmembranei348 – 371HelicalSequence analysisAdd BLAST24
Transmembranei403 – 424HelicalSequence analysisAdd BLAST22
Transmembranei871 – 890HelicalSequence analysisAdd BLAST20
Transmembranei897 – 922HelicalSequence analysisAdd BLAST26
Transmembranei928 – 948HelicalSequence analysisAdd BLAST21
Transmembranei969 – 994HelicalSequence analysisAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini244 – 370SSDInterPro annotationAdd BLAST127

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 26DisorderedSequence analysisAdd BLAST26
Regioni1056 – 1078DisorderedSequence analysisAdd BLAST23

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004869 MMPL_dom
IPR000731 SSD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03176 MMPL, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50156 SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045ILW7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDVLMQPVR TPRPSTNLRS KPLRPTGDGG VFPRLGRLIV RRPWVVIAFW
60 70 80 90 100
VALAGLLAPT VPSLDAISQR HPVAILPSDA PVLVSTRQMT AAFREAGLQS
110 120 130 140 150
VAVVVLSDAK GLGAADERSY KELVDALRRD TRDVVMLQDF VTTPPLRELM
160 170 180 190 200
TSKDNQAWIL PVGLPGDLGS TQSKQAYARV ADIVEHQVAG STLTANLTGP
210 220 230 240 250
AATVADLNLT GQRDRSRIEF AITILLLVIL LIIYGNPITM VLPLITIGMS
260 270 280 290 300
VVVAQRLVAI AGLAGLGIAN QSIIFMSGMM VGAGTDYAVF LISRYHDYLR
310 320 330 340 350
QGADSDQAVK KALTSIGKVI AASAATVAIT FLGMVFTQLG ILKTVGPMLG
360 370 380 390 400
ISVAVVFFAA VTLLPALMVL TGRRGWIAPR RDLTRRFWRS SGVHIVRRPK
410 420 430 440 450
THLLASALVL VILAGCAGLA RYNYDDRKTL PASVESSIGY AALDKHFPSN
460 470 480 490 500
LIIPEYLFIQ SSTDLRTPKA LADLEQMVQR VSQVPGVAMV RGITRPAGRS
510 520 530 540 550
LEQARTSWQA GEVGSKLDEG SKQIAVHTGD IDKLAGGANL MASKLGDVRA
560 570 580 590 600
QVNRAISTVG GLIDALAYLQ DLLGGNRVLG ELEGAEKLIG SMRALGDTID
610 620 630 640 650
ADASFVANNT EWASPVLGAL DSSPMCTADP ACASARTELQ RLVTARDDGT
660 670 680 690 700
LAKISELARQ LQATRAVQTL AATVSGLRGA LATVIRAMGS LGMSSPGGVR
710 720 730 740 750
SKINLVNKGV NDLADGSRQL AEGVQLLVDQ VKKMGFGLGE ASAFLLAMKD
760 770 780 790 800
TATTPAMAGF YIPPELLSYA TGESVKAETM PSEYRDLLGG LNVDQLKKVA
810 820 830 840 850
AAFISPDGHS IRYLIQTDLN PFSTAAMDQI DAITAAARGA QPNTALADAK
860 870 880 890 900
VSVVGLPVVL KDTRDYSDHD LRLIIAMTVC IVLLILIVLL RAIVAPLYLI
910 920 930 940 950
GSVIVSYLAA LGIGVIVFQF LLGQEMHWSI PGLTFVILVA VGADYNMLLI
960 970 980 990 1000
SRLREEAVLG VRSGVIRTVA STGGVITAAG LIMAASMYGL VFASLGSVVQ
1010 1020 1030 1040 1050
GAFVLGTGLL LDTFLVRTVT VPAIAVLVGQ ANWWLPSSWR PATWWPLGRR
1060 1070 1080
RGRAQRTKRK PLLPKEEEEQ SPPDDDDLIG LWLHDGLRL
Length:1,089
Mass (Da):115,998
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9F842026831060F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CIEA01000031 Genomic DNA Translation: CKS42163.1
CQGE01000023 Genomic DNA Translation: CNM86031.1
FPTZ01000001 Genomic DNA Translation: SGG99302.1
SMOE01000091 Genomic DNA Translation: TFB22188.1
SZTS01000036 Genomic DNA Translation: TKR39621.1
SZTU01000034 Genomic DNA Translation: TKR51641.1

NCBI Reference Sequences

More...
RefSeqi
WP_003899710.1, NZ_VOVY01000026.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC48346; AMC48346; RN05_4070
CKQ75538; CKQ75538; ERS027661_00003
CKR13571; CKR13571; ERS027656_00661
CKR83554; CKR83554; ERS027666_00066
CKR89063; CKR89063; ERS027646_00885
CNG67045; CNG67045; ERS124361_01537
CNM86031; CNM86031; ERS023446_01459
CNT74837; CNT74837; ERS007670_00080
CNT92796; CNT92796; ERS007665_00041
CNY11609; CNY11609; ERS013471_00466
COU60430; COU60430; ERS007672_00021
COV36453; COV36453; ERS007720_00035
CRH09894; CRH09894; BN1213_00413
CRH14730; CRH14730; BN1303_02801

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.3364

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CIEA01000031 Genomic DNA Translation: CKS42163.1
CQGE01000023 Genomic DNA Translation: CNM86031.1
FPTZ01000001 Genomic DNA Translation: SGG99302.1
SMOE01000091 Genomic DNA Translation: TFB22188.1
SZTS01000036 Genomic DNA Translation: TKR39621.1
SZTU01000034 Genomic DNA Translation: TKR51641.1
RefSeqiWP_003899710.1, NZ_VOVY01000026.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC48346; AMC48346; RN05_4070
CKQ75538; CKQ75538; ERS027661_00003
CKR13571; CKR13571; ERS027656_00661
CKR83554; CKR83554; ERS027666_00066
CKR89063; CKR89063; ERS027646_00885
CNG67045; CNG67045; ERS124361_01537
CNM86031; CNM86031; ERS023446_01459
CNT74837; CNT74837; ERS007670_00080
CNT92796; CNT92796; ERS007665_00041
CNY11609; CNY11609; ERS013471_00466
COU60430; COU60430; ERS007672_00021
COV36453; COV36453; ERS007720_00035
CRH09894; CRH09894; BN1213_00413
CRH14730; CRH14730; BN1303_02801
PATRICifig|1773.211.peg.3364

Family and domain databases

InterProiView protein in InterPro
IPR004869 MMPL_dom
IPR000731 SSD
PfamiView protein in Pfam
PF03176 MMPL, 2 hits
PROSITEiView protein in PROSITE
PS50156 SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045ILW7_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045ILW7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: December 11, 2019
This is version 55 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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