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Entry version 64 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

HTH-type transcriptional regulator KstR2

Gene

kstR2_3

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi32 – 51H-T-H motifPROSITE-ProRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationARBA annotation
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HTH-type transcriptional regulator KstR2Imported
Submitted name:
TetR family transcriptional regulatorImported
Submitted name:
TetR family transcriptional regulator KstR2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:kstR2_3Imported
Synonyms:kstR2Imported, kstR2_1Imported, kstR2_2Imported, kstR2_4Imported, kstR2_5Imported, kstR2_6Imported, kstR2_7Imported
ORF Names:DSI38_11835Imported, E5M52_11325Imported, ERS007657_02212Imported, ERS007661_01547Imported, ERS007663_01227Imported, ERS007665_02346Imported, ERS007670_03546Imported, ERS007679_01533Imported, ERS007681_01345Imported, ERS007688_02819Imported, ERS007703_03859Imported, ERS007720_02465Imported, ERS007741_03423Imported, ERS013471_03528Imported, ERS023446_03581Imported, ERS027646_00142Imported, ERS075361_02115Imported, ERS094182_02344Imported, F6W99_02236Imported, F9908_05225Imported, FRD82_03390Imported, SAMEA2683035_00656Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000431688 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 69HTH tetR-typeInterPro annotationAdd BLAST61

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001647, HTH_TetR
IPR041490, KstR2_TetR_C
IPR036271, Tet_transcr_reg_TetR-rel_C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17932, TetR_C_24, 1 hit
PF00440, TetR_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00455, HTHTETR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF48498, SSF48498, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50977, HTH_TETR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045IL86-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRVAGQVNS RRGELLELAA AMFAERGLRA TTVRDIADGA GILSGSLYHH
60 70 80 90 100
FASKEEMVDE LLRGFLDWLF ARYRDIVDST ANPLERLQGL FMASFEAIEH
110 120 130 140 150
HHAQVVIYQD EAQRLASQPR FSYIEDRNKQ QRKMWVDVLN QGIEEGYFRP
160 170 180 190 200
DLDVDLVYRF IRDTTWVSVR WYRPGGPLTA QQVGQQYLAI VLGGITKEGV
Length:200
Mass (Da):22,906
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE1B29D39CF4D955F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000132 Genomic DNA Translation: CFE38974.1
CFOH01000519 Genomic DNA Translation: CFE59748.1
CGCX01000812 Genomic DNA Translation: CFR83923.1
CNGE01000011 Genomic DNA Translation: CKR59409.1
CQAC01000014 Genomic DNA Translation: CNG75222.1
CQGE01000122 Genomic DNA Translation: CNN47270.1
CQPV01000141 Genomic DNA Translation: CNU44420.1
CQQC01000441 Genomic DNA Translation: CNV03869.1
CQPW01000485 Genomic DNA Translation: CNV19794.1
CQPL01001019 Genomic DNA Translation: CNV54662.1
CQTT01000145 Genomic DNA Translation: CNZ09366.1
CSAD01000168 Genomic DNA Translation: COV29738.1
CSAJ01000319 Genomic DNA Translation: COW36410.1
CSAE01000579 Genomic DNA Translation: COW56263.1
CHKL01000515 Genomic DNA Translation: COW91807.1
CVKR01000017 Genomic DNA Translation: CRF26898.1
WFKV01000004 Genomic DNA Translation: KAB7806083.1
CP044345 Genomic DNA Translation: QEX91441.1
QSXJ01000815 Genomic DNA Translation: REM67301.1
FPTZ01000003 Genomic DNA Translation: SGH24384.1
SRLJ01000022 Genomic DNA Translation: TGD76402.1
VOOQ01000062 Genomic DNA Translation: TXB94766.1

NCBI Reference Sequences

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RefSeqi
WP_003419329.1, NZ_WUJD01000059.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC48071; AMC48071; RN05_3795
CFE38974; CFE38974; ERS007681_01345
CFE59748; CFE59748; ERS007688_02819
CFR83923; CFR83923; ERS007657_02212
CKR59409; CKR59409; ERS027646_00142
CKS38452; CKS38452; ERS027653_02929
CKS59978; CKS59978; ERS027656_03213
CKT46557; CKT46557; ERS027652_04544
CKT72291; CKT72291; ERS027666_03318
CNG53483; CNG53483; ERS124361_01182
CNN47270; CNN47270; ERS023446_03581
CNU44420; CNU44420; ERS007663_01227
CNV03869; CNV03869; ERS007661_01547
CNV19794; CNV19794; ERS007665_02346
CNV54662; CNV54662; ERS007670_03546
CNZ09366; CNZ09366; ERS013471_03528
COV29738; COV29738; ERS007679_01533
COW17327; COW17327; ERS007726_00236
COW36410; COW36410; ERS007720_02465
COW56263; COW56263; ERS007703_03859
COW65292; COW65292; ERS007731_00674
COW91807; COW91807; ERS007741_03423
CRH15220; CRH15220; BN1303_03037
CRH16681; CRH16681; BN1213_03930

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23490169

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.3988

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000132 Genomic DNA Translation: CFE38974.1
CFOH01000519 Genomic DNA Translation: CFE59748.1
CGCX01000812 Genomic DNA Translation: CFR83923.1
CNGE01000011 Genomic DNA Translation: CKR59409.1
CQAC01000014 Genomic DNA Translation: CNG75222.1
CQGE01000122 Genomic DNA Translation: CNN47270.1
CQPV01000141 Genomic DNA Translation: CNU44420.1
CQQC01000441 Genomic DNA Translation: CNV03869.1
CQPW01000485 Genomic DNA Translation: CNV19794.1
CQPL01001019 Genomic DNA Translation: CNV54662.1
CQTT01000145 Genomic DNA Translation: CNZ09366.1
CSAD01000168 Genomic DNA Translation: COV29738.1
CSAJ01000319 Genomic DNA Translation: COW36410.1
CSAE01000579 Genomic DNA Translation: COW56263.1
CHKL01000515 Genomic DNA Translation: COW91807.1
CVKR01000017 Genomic DNA Translation: CRF26898.1
WFKV01000004 Genomic DNA Translation: KAB7806083.1
CP044345 Genomic DNA Translation: QEX91441.1
QSXJ01000815 Genomic DNA Translation: REM67301.1
FPTZ01000003 Genomic DNA Translation: SGH24384.1
SRLJ01000022 Genomic DNA Translation: TGD76402.1
VOOQ01000062 Genomic DNA Translation: TXB94766.1
RefSeqiWP_003419329.1, NZ_WUJD01000059.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC48071; AMC48071; RN05_3795
CFE38974; CFE38974; ERS007681_01345
CFE59748; CFE59748; ERS007688_02819
CFR83923; CFR83923; ERS007657_02212
CKR59409; CKR59409; ERS027646_00142
CKS38452; CKS38452; ERS027653_02929
CKS59978; CKS59978; ERS027656_03213
CKT46557; CKT46557; ERS027652_04544
CKT72291; CKT72291; ERS027666_03318
CNG53483; CNG53483; ERS124361_01182
CNN47270; CNN47270; ERS023446_03581
CNU44420; CNU44420; ERS007663_01227
CNV03869; CNV03869; ERS007661_01547
CNV19794; CNV19794; ERS007665_02346
CNV54662; CNV54662; ERS007670_03546
CNZ09366; CNZ09366; ERS013471_03528
COV29738; COV29738; ERS007679_01533
COW17327; COW17327; ERS007726_00236
COW36410; COW36410; ERS007720_02465
COW56263; COW56263; ERS007703_03859
COW65292; COW65292; ERS007731_00674
COW91807; COW91807; ERS007741_03423
CRH15220; CRH15220; BN1303_03037
CRH16681; CRH16681; BN1213_03930
GeneIDi23490169
PATRICifig|1773.206.peg.3988

Family and domain databases

InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001647, HTH_TetR
IPR041490, KstR2_TetR_C
IPR036271, Tet_transcr_reg_TetR-rel_C_sf
PfamiView protein in Pfam
PF17932, TetR_C_24, 1 hit
PF00440, TetR_N, 1 hit
PRINTSiPR00455, HTHTETR
SUPFAMiSSF46689, SSF46689, 1 hit
SSF48498, SSF48498, 1 hit
PROSITEiView protein in PROSITE
PS50977, HTH_TETR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045IL86_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045IL86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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