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Entry version 56 (11 Dec 2019)
Sequence version 1 (09 Jul 2014)
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Protein

Diacylglycerol O-acyltransferase

Gene

tgs1_2

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: triacylglycerol biosynthesis

This protein is involved in the pathway triacylglycerol biosynthesis, which is part of Glycerolipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway triacylglycerol biosynthesis and in Glycerolipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
Biological processGlycerol metabolismUniRule annotation, Lipid biosynthesisUniRule annotation, Lipid metabolism

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00282

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diacylglycerol O-acyltransferaseUniRule annotation (EC:2.3.1.20UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tgs1_2Imported
Synonyms:tgs1_1Imported
ORF Names:ERS007703_01797Imported, ERS023446_02733Imported, ERS027651_03989Imported, EZX46_08595Imported, FDK60_02670Imported, SAMEA2682864_03246Imported, SAMEA2683035_03432Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000183655 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000298273 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000305204 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 237WES_acyltransfInterPro annotationAdd BLAST234
Domaini271 – 400DUF1298InterPro annotationAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 446DisorderedSequence analysisAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the long-chain O-acyltransferase family.UniRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014292 Acyl_transf_WS/DGAT
IPR009721 O-acyltransferase_WSD1_C
IPR004255 O-acyltransferase_WSD1_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06974 DUF1298, 1 hit
PF03007 WES_acyltransf, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02946 acyl_WS_DGAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045I6M8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLTALDAG FLKSRDPERH PGLAIGAVAV VNGAAPSYDQ LKTVLTERIK
60 70 80 90 100
SIPRCTQVLA TEWIDYPGFD LTQHVRRVAL PRPGDEAELF RAIALALERP
110 120 130 140 150
LDPDRPLWEC WIIEGLNGNR WAILIKIHHC MAGAMSAAHL LARLCDDADG
160 170 180 190 200
SAFANNVDIK QIPPYGDARS WAETLWRMSV SIAGAVCTAA ARAVSWPAVT
210 220 230 240 250
SPAGPVTTRR RYQAVRVPRD AVDAVCHKFG VTANDVALAA ITEGFRTVLL
260 270 280 290 300
HRGQQPRADS LRTLEKTDGS SAMLPYLPVE YDDPVRRLRT VHNRSQQSGR
310 320 330 340 350
RQPDSLSDYT PLMLCAKMIH ALARLPQQGI VTLATSAPRP RHQLRLMGQK
360 370 380 390 400
MDQVLPIPPT ALQLSTGIAV LSYGDELVFG ITADYDAASE MQQLVNGIEL
410 420 430 440
GVARLVALSD DSVLLFTKDR RKRSSRALPS AARRGRPSVP TARARH
Length:446
Mass (Da):48,847
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E7CC07E93CC15AD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CIEA01000076 Genomic DNA Translation: CKS98440.1
CQGE01000067 Genomic DNA Translation: CNN26577.1
CSAE01000167 Genomic DNA Translation: COV65084.1
FPTZ01000031 Genomic DNA Translation: SGI36417.1
FPXX01000023 Genomic DNA Translation: SGM82555.1
SMOE01000087 Genomic DNA Translation: TFB24646.1
SZTS01000005 Genomic DNA Translation: TKR41822.1

NCBI Reference Sequences

More...
RefSeqi
WP_003900036.1, NZ_VOVY01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC47858; AMC47858; RN05_3582
CFE43190; CFE43190; ERS007681_03356
CFE48502; CFE48502; ERS007688_01107
CKO50995; CKO50995; ERS024276_01667
CKP23429; CKP23429; ERS024213_01708
CKR29670; CKR29670; ERS027652_01093
CKR42796; CKR42796; ERS027653_01291
CKR44261; CKR44261; ERS027656_01289
CKR58935; CKR58935; ERS027659_01791
CKS10604; CKS10604; ERS027661_02596
CKS94787; CKS94787; ERS027646_02722
CKU07126; CKU07126; ERS027666_03749
CNH33734; CNH33734; ERS124361_03423
CNN26577; CNN26577; ERS023446_02733
CNV40834; CNV40834; ERS007663_03192
CNY85505; CNY85505; ERS013471_02882
COV65084; COV65084; ERS007703_01797
COV79961; COV79961; ERS007722_00839
COW06086; COW06086; ERS007672_02927
COW15434; COW15434; ERS007679_03251
COW39752; COW39752; ERS007741_02403
CRH11642; CRH11642; BN1213_01346
CRH16231; CRH16231; BN1303_03563

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.2645

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CIEA01000076 Genomic DNA Translation: CKS98440.1
CQGE01000067 Genomic DNA Translation: CNN26577.1
CSAE01000167 Genomic DNA Translation: COV65084.1
FPTZ01000031 Genomic DNA Translation: SGI36417.1
FPXX01000023 Genomic DNA Translation: SGM82555.1
SMOE01000087 Genomic DNA Translation: TFB24646.1
SZTS01000005 Genomic DNA Translation: TKR41822.1
RefSeqiWP_003900036.1, NZ_VOVY01000034.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC47858; AMC47858; RN05_3582
CFE43190; CFE43190; ERS007681_03356
CFE48502; CFE48502; ERS007688_01107
CKO50995; CKO50995; ERS024276_01667
CKP23429; CKP23429; ERS024213_01708
CKR29670; CKR29670; ERS027652_01093
CKR42796; CKR42796; ERS027653_01291
CKR44261; CKR44261; ERS027656_01289
CKR58935; CKR58935; ERS027659_01791
CKS10604; CKS10604; ERS027661_02596
CKS94787; CKS94787; ERS027646_02722
CKU07126; CKU07126; ERS027666_03749
CNH33734; CNH33734; ERS124361_03423
CNN26577; CNN26577; ERS023446_02733
CNV40834; CNV40834; ERS007663_03192
CNY85505; CNY85505; ERS013471_02882
COV65084; COV65084; ERS007703_01797
COV79961; COV79961; ERS007722_00839
COW06086; COW06086; ERS007672_02927
COW15434; COW15434; ERS007679_03251
COW39752; COW39752; ERS007741_02403
CRH11642; CRH11642; BN1213_01346
CRH16231; CRH16231; BN1303_03563
PATRICifig|1773.206.peg.2645

Enzyme and pathway databases

UniPathwayiUPA00282

Family and domain databases

InterProiView protein in InterPro
IPR014292 Acyl_transf_WS/DGAT
IPR009721 O-acyltransferase_WSD1_C
IPR004255 O-acyltransferase_WSD1_N
PfamiView protein in Pfam
PF06974 DUF1298, 1 hit
PF03007 WES_acyltransf, 1 hit
TIGRFAMsiTIGR02946 acyl_WS_DGAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045I6M8_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045I6M8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: December 11, 2019
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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