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Entry version 69 (02 Jun 2021)
Sequence version 1 (09 Jul 2014)
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Protein

Aspartokinase

Gene

ask

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotationARBA annotation This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotationARBA annotation This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotationARBA annotation This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei47SubstrateUniRule annotation1
Binding sitei74SubstrateUniRule annotation1
Binding sitei185ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi7 – 10ATPUniRule annotation4
Nucleotide bindingi174 – 175ATPUniRule annotation2
Nucleotide bindingi210 – 211ATPUniRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationARBA annotation, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisARBA annotation, Lysine biosynthesisARBA annotation
LigandATP-bindingUniRule annotationARBA annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00034;UER00015
UPA00050;UER00461
UPA00051;UER00462

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AspartokinaseUniRule annotation (EC:2.7.2.4UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:askImported
ORF Names:C0094_20280Imported, DSI38_25705Imported, E5M05_18090Imported, E5M52_16400Imported, E5M78_15945Imported, ERS007663_01401Imported, ERS007670_02765Imported, ERS007681_01742Imported, ERS007703_00251Imported, ERS007720_01427Imported, ERS007722_01111Imported, ERS007741_02031Imported, ERS013471_00664Imported, ERS023446_00141Imported, ERS024276_00626Imported, ERS027646_01009Imported, ERS027659_00614Imported, ERS094182_02508Imported, F6W99_02389Imported, FRD82_04715Imported, GCL30_14185Imported, SAMEA2683035_00810Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000470375 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000298278 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000235535 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini267 – 352ACTInterPro annotationAdd BLAST86

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aspartokinase family.UniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04261, AAK_AKii-LysC-BS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1160.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036393, AceGlu_kinase-like_sf
IPR002912, ACT_dom
IPR041740, AKii-LysC-BS
IPR001048, Asp/Glu/Uridylate_kinase
IPR005260, Asp_kin_monofn
IPR001341, Asp_kinase
IPR018042, Aspartate_kinase_CS
IPR027795, CASTOR_ACT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00696, AA_kinase, 1 hit
PF01842, ACT, 1 hit
PF13840, ACT_7, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000726, Asp_kin, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53633, SSF53633, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00656, asp_kin_monofn, 1 hit
TIGR00657, asp_kinases, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51671, ACT, 1 hit
PS00324, ASPARTOKINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045I590-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALVVQKYGG SSVADAERIR RVAERIVATK KQGNDVVVVV SAMGDTTDDL
60 70 80 90 100
LDLAQQVCPA PPPRELDMLL TAGERISNAL VAMAIESLGA HARSFTGSQA
110 120 130 140 150
GVITTGTHGN AKIIDVTPGR LQTALEEGRV VLVAGFQGVS QDTKDVTTLG
160 170 180 190 200
RGGSDTTAVA MAAALGADVC EIYTDVDGIF SADPRIVRNA RKLDTVTFEE
210 220 230 240 250
MLEMAACGAK VLMLRCVEYA RRHNIPVHVR SSYSDRPGTV VVGSIKDVPM
260 270 280 290 300
EDPILTGVAH DRSEAKVTIV GLPDIPGYAA KVFRAVADAD VNIDMVLQNV
310 320 330 340 350
SKVEDGKTDI TFTCSRDVGP AAVEKLDSLR NEIGFSQLLY DDHIGKVSLI
360 370 380 390 400
GAGMRSHPGV TATFCEALAA VGVNIELIST SEIRISVLCR DTELDKAVVA
410 420
LHEAFGLGGD EEATVYAGTG R
Length:421
Mass (Da):44,462
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0567323B0D2085A7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP85175.1
CFOE01000190 Genomic DNA Translation: CFE39362.1
CNCN01000092 Genomic DNA Translation: CKN89410.1
CNFT01000086 Genomic DNA Translation: CKR04797.1
CNGE01000127 Genomic DNA Translation: CKR95824.1
CQGE01000002 Genomic DNA Translation: CNM36801.1
CQPV01000170 Genomic DNA Translation: CNU54101.1
CQPL01000639 Genomic DNA Translation: CNV24006.1
CQTT01000011 Genomic DNA Translation: CNY16808.1
CSAE01000015 Genomic DNA Translation: COV00160.1
CSAM01000057 Genomic DNA Translation: COV91832.1
CSAJ01000142 Genomic DNA Translation: COW01381.1
CHKL01000207 Genomic DNA Translation: COW27253.1
CVKR01000019 Genomic DNA Translation: CRF27061.1
WFLD01000017 Genomic DNA Translation: KAB7837370.1
CP044345 Genomic DNA Translation: QEX91591.1
QSXJ01001112 Genomic DNA Translation: REM59463.1
FPTZ01000003 Genomic DNA Translation: SGH28908.1
SRLJ01000042 Genomic DNA Translation: TGD72395.1
SRLK01000041 Genomic DNA Translation: TGD89480.1
SRLI01000046 Genomic DNA Translation: TGD98814.1
VOOQ01000095 Genomic DNA Translation: TXB94514.1

NCBI Reference Sequences

More...
RefSeqi
WP_003419828.1, NZ_WUJD01000060.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CKQ96089; CKQ96089; ERS027654_00385
CKQ97809; CKQ97809; ERS027644_00257
CKR04797; CKR04797; ERS027659_00614
CKR55033; CKR55033; ERS027651_00679
CKR95824; CKR95824; ERS027646_01009
CKT01214; CKT01214; ERS027656_03766
CNG96115; CNG96115; ERS124361_02433
CNM36801; CNM36801; ERS023446_00141
COV91832; COV91832; ERS007722_01111
COW27253; COW27253; ERS007741_02031
SGH28908; SGH28908; SAMEA2683035_00810
SGM80025; SGM80025; SAMEA2682864_03207

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.2476

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP85175.1
CFOE01000190 Genomic DNA Translation: CFE39362.1
CNCN01000092 Genomic DNA Translation: CKN89410.1
CNFT01000086 Genomic DNA Translation: CKR04797.1
CNGE01000127 Genomic DNA Translation: CKR95824.1
CQGE01000002 Genomic DNA Translation: CNM36801.1
CQPV01000170 Genomic DNA Translation: CNU54101.1
CQPL01000639 Genomic DNA Translation: CNV24006.1
CQTT01000011 Genomic DNA Translation: CNY16808.1
CSAE01000015 Genomic DNA Translation: COV00160.1
CSAM01000057 Genomic DNA Translation: COV91832.1
CSAJ01000142 Genomic DNA Translation: COW01381.1
CHKL01000207 Genomic DNA Translation: COW27253.1
CVKR01000019 Genomic DNA Translation: CRF27061.1
WFLD01000017 Genomic DNA Translation: KAB7837370.1
CP044345 Genomic DNA Translation: QEX91591.1
QSXJ01001112 Genomic DNA Translation: REM59463.1
FPTZ01000003 Genomic DNA Translation: SGH28908.1
SRLJ01000042 Genomic DNA Translation: TGD72395.1
SRLK01000041 Genomic DNA Translation: TGD89480.1
SRLI01000046 Genomic DNA Translation: TGD98814.1
VOOQ01000095 Genomic DNA Translation: TXB94514.1
RefSeqiWP_003419828.1, NZ_WUJD01000060.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCKQ96089; CKQ96089; ERS027654_00385
CKQ97809; CKQ97809; ERS027644_00257
CKR04797; CKR04797; ERS027659_00614
CKR55033; CKR55033; ERS027651_00679
CKR95824; CKR95824; ERS027646_01009
CKT01214; CKT01214; ERS027656_03766
CNG96115; CNG96115; ERS124361_02433
CNM36801; CNM36801; ERS023446_00141
COV91832; COV91832; ERS007722_01111
COW27253; COW27253; ERS007741_02031
SGH28908; SGH28908; SAMEA2683035_00810
SGM80025; SGM80025; SAMEA2682864_03207
PATRICifig|1773.206.peg.2476

Enzyme and pathway databases

UniPathwayiUPA00034;UER00015
UPA00050;UER00461
UPA00051;UER00462

Family and domain databases

CDDicd04261, AAK_AKii-LysC-BS, 1 hit
Gene3Di3.40.1160.10, 1 hit
InterProiView protein in InterPro
IPR036393, AceGlu_kinase-like_sf
IPR002912, ACT_dom
IPR041740, AKii-LysC-BS
IPR001048, Asp/Glu/Uridylate_kinase
IPR005260, Asp_kin_monofn
IPR001341, Asp_kinase
IPR018042, Aspartate_kinase_CS
IPR027795, CASTOR_ACT_dom
PfamiView protein in Pfam
PF00696, AA_kinase, 1 hit
PF01842, ACT, 1 hit
PF13840, ACT_7, 1 hit
PIRSFiPIRSF000726, Asp_kin, 2 hits
SUPFAMiSSF53633, SSF53633, 1 hit
TIGRFAMsiTIGR00656, asp_kin_monofn, 1 hit
TIGR00657, asp_kinases, 1 hit
PROSITEiView protein in PROSITE
PS51671, ACT, 1 hit
PS00324, ASPARTOKINASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045I590_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045I590
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 2, 2021
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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