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Entry version 60 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Flavin-dependent monooxygenase

Gene

hsaA_1

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenaseImported, Oxidoreductase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Flavin-dependent monooxygenaseImported
Submitted name:
Flavin-dependent monooxygenase oxygenase subunit HsaAImported
Submitted name:
OxidoreductaseImported
Submitted name:
Pigment production hydroxylaseImported (EC:1.-.-.-Imported, EC:1.14.14.12Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hsaA_1Imported
Synonyms:hsaAImported, hsaA_2Imported
ORF Names:DSI38_07635Imported, E5M52_11400Imported, ERS007657_00778Imported, ERS007661_00366Imported, ERS007663_01171Imported, ERS007665_00878Imported, ERS007670_01860Imported, ERS007679_00574Imported, ERS007681_00678Imported, ERS007688_00366Imported, ERS007703_02037Imported, ERS007720_02909Imported, ERS007722_01140Imported, ERS007741_03067Imported, ERS013471_01597Imported, ERS023446_02467Imported, ERS024276_00918Imported, ERS027646_02380Imported, ERS027659_02020Imported, ERS027661_00435Imported, ERS075361_02102Imported, ERS094182_02331Imported, F6W99_02249Imported, SAMEA2683035_00669Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000041288 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini240 – 372Acyl-CoA_dh_2InterPro annotationAdd BLAST133

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013107, Acyl-CoA_DH_C_dom
IPR036250, AcylCo_DH-like_C
IPR037069, AcylCoA_DH/ox_N_sf
IPR009100, AcylCoA_DH/oxidase_NM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08028, Acyl-CoA_dh_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47203, SSF47203, 1 hit
SSF56645, SSF56645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045I4W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIQQRDAQ SVLAAIDNLL PEIRDRAQAT EDLRRLPDET VKALDDVGFF
60 70 80 90 100
TLLQPQQWGG LQCDPALFFE ATRRLASVCG STGWVSSIVG VHNWHLALFD
110 120 130 140 150
QRAQEEVWGE DPSTRISSSY APMGAGVVVD GGYLVNGSWN WSSGCDHASW
160 170 180 190 200
TFVGGPVIKD GRPVDFGSFL IPRSEYEIKD VWYVVGLRGT GSNTLVVKDV
210 220 230 240 250
FVPRHRFLSY KAMNDHTAGG LATNSAPVYK MPWGTMHPTT ISAPIVGMAY
260 270 280 290 300
GAYAAHVEHQ GKRVRAAFAG EKAKDDPFAK VRIAEAASDI DAAWRQLIGN
310 320 330 340 350
VSDEYALLAA GKEIPFELRA RARRDQVRAT GRSIASIDRL FEASGATALS
360 370 380 390
NEAPIQRFWR DAHAGRVHAA NDPERAYVIF GNHEFGLPPG DTMV
Length:394
Mass (Da):43,143
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3103435D8EB1485
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000052 Genomic DNA Translation: CFE37133.1
CFOH01000032 Genomic DNA Translation: CFE46729.1
CGCX01000193 Genomic DNA Translation: CFR69623.1
CNCN01000152 Genomic DNA Translation: CKO03088.1
CNFU01000050 Genomic DNA Translation: CKR00547.1
CNFT01000433 Genomic DNA Translation: CKR69648.1
CNGE01000430 Genomic DNA Translation: CKS73848.1
CQAC01000014 Genomic DNA Translation: CNG74853.1
CQGE01000055 Genomic DNA Translation: CNN19473.1
CQQC01000068 Genomic DNA Translation: CNU25796.1
CQPW01000115 Genomic DNA Translation: CNU32766.1
CQPV01000133 Genomic DNA Translation: CNU41650.1
CQPL01000334 Genomic DNA Translation: CNU67769.1
CQTT01000033 Genomic DNA Translation: CNY43894.1
CSAD01000046 Genomic DNA Translation: COU88736.1
CSAE01000200 Genomic DNA Translation: COV77915.1
CSAM01000059 Genomic DNA Translation: COV92912.1
CSAJ01000417 Genomic DNA Translation: COW59583.1
CHKL01000420 Genomic DNA Translation: COW74545.1
CVKR01000017 Genomic DNA Translation: CRF26885.1
CP044345 Genomic DNA Translation: QEX91454.1
QSXJ01000545 Genomic DNA Translation: REM68089.1
FPTZ01000003 Genomic DNA Translation: SGH24808.1
SRLJ01000022 Genomic DNA Translation: TGD76416.1

NCBI Reference Sequences

More...
RefSeqi
WP_003900101.1, NZ_WUJD01000059.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC48084; AMC48084; RN05_3808
CFE37133; CFE37133; ERS007681_00678
CFE46729; CFE46729; ERS007688_00366
CFR69623; CFR69623; ERS007657_00778
CKO03088; CKO03088; ERS024276_00918
CKP20352; CKP20352; ERS024213_01659
CKQ77293; CKQ77293; ERS027653_00063
CKR00547; CKR00547; ERS027661_00435
CKR43180; CKR43180; ERS027654_01338
CKR69648; CKR69648; ERS027659_02020
CKS31845; CKS31845; ERS027652_03032
CKS71604; CKS71604; ERS027666_01484
CKS73848; CKS73848; ERS027646_02380
CKU54123; CKU54123; ERS031537_00739
CNN19473; CNN19473; ERS023446_02467
CNU25796; CNU25796; ERS007661_00366
CNU32766; CNU32766; ERS007665_00878
CNU41650; CNU41650; ERS007663_01171
CNU67769; CNU67769; ERS007670_01860
CNY43894; CNY43894; ERS013471_01597
COU88736; COU88736; ERS007679_00574
COU97081; COU97081; ERS007672_00754
COV77915; COV77915; ERS007703_02037
COV92912; COV92912; ERS007722_01140
COW14467; COW14467; ERS007726_00169
COW59583; COW59583; ERS007720_02909
COW74545; COW74545; ERS007741_03067
CRH15245; CRH15245; BN1303_03050
CRH16656; CRH16656; BN1213_03917

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23490155

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.3973

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000052 Genomic DNA Translation: CFE37133.1
CFOH01000032 Genomic DNA Translation: CFE46729.1
CGCX01000193 Genomic DNA Translation: CFR69623.1
CNCN01000152 Genomic DNA Translation: CKO03088.1
CNFU01000050 Genomic DNA Translation: CKR00547.1
CNFT01000433 Genomic DNA Translation: CKR69648.1
CNGE01000430 Genomic DNA Translation: CKS73848.1
CQAC01000014 Genomic DNA Translation: CNG74853.1
CQGE01000055 Genomic DNA Translation: CNN19473.1
CQQC01000068 Genomic DNA Translation: CNU25796.1
CQPW01000115 Genomic DNA Translation: CNU32766.1
CQPV01000133 Genomic DNA Translation: CNU41650.1
CQPL01000334 Genomic DNA Translation: CNU67769.1
CQTT01000033 Genomic DNA Translation: CNY43894.1
CSAD01000046 Genomic DNA Translation: COU88736.1
CSAE01000200 Genomic DNA Translation: COV77915.1
CSAM01000059 Genomic DNA Translation: COV92912.1
CSAJ01000417 Genomic DNA Translation: COW59583.1
CHKL01000420 Genomic DNA Translation: COW74545.1
CVKR01000017 Genomic DNA Translation: CRF26885.1
CP044345 Genomic DNA Translation: QEX91454.1
QSXJ01000545 Genomic DNA Translation: REM68089.1
FPTZ01000003 Genomic DNA Translation: SGH24808.1
SRLJ01000022 Genomic DNA Translation: TGD76416.1
RefSeqiWP_003900101.1, NZ_WUJD01000059.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC48084; AMC48084; RN05_3808
CFE37133; CFE37133; ERS007681_00678
CFE46729; CFE46729; ERS007688_00366
CFR69623; CFR69623; ERS007657_00778
CKO03088; CKO03088; ERS024276_00918
CKP20352; CKP20352; ERS024213_01659
CKQ77293; CKQ77293; ERS027653_00063
CKR00547; CKR00547; ERS027661_00435
CKR43180; CKR43180; ERS027654_01338
CKR69648; CKR69648; ERS027659_02020
CKS31845; CKS31845; ERS027652_03032
CKS71604; CKS71604; ERS027666_01484
CKS73848; CKS73848; ERS027646_02380
CKU54123; CKU54123; ERS031537_00739
CNN19473; CNN19473; ERS023446_02467
CNU25796; CNU25796; ERS007661_00366
CNU32766; CNU32766; ERS007665_00878
CNU41650; CNU41650; ERS007663_01171
CNU67769; CNU67769; ERS007670_01860
CNY43894; CNY43894; ERS013471_01597
COU88736; COU88736; ERS007679_00574
COU97081; COU97081; ERS007672_00754
COV77915; COV77915; ERS007703_02037
COV92912; COV92912; ERS007722_01140
COW14467; COW14467; ERS007726_00169
COW59583; COW59583; ERS007720_02909
COW74545; COW74545; ERS007741_03067
CRH15245; CRH15245; BN1303_03050
CRH16656; CRH16656; BN1213_03917
GeneIDi23490155
PATRICifig|1773.206.peg.3973

Family and domain databases

Gene3Di1.10.540.10, 1 hit
InterProiView protein in InterPro
IPR013107, Acyl-CoA_DH_C_dom
IPR036250, AcylCo_DH-like_C
IPR037069, AcylCoA_DH/ox_N_sf
IPR009100, AcylCoA_DH/oxidase_NM_dom
PfamiView protein in Pfam
PF08028, Acyl-CoA_dh_2, 1 hit
SUPFAMiSSF47203, SSF47203, 1 hit
SSF56645, SSF56645, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045I4W3_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045I4W3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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