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Entry version 69 (02 Jun 2021)
Sequence version 1 (09 Jul 2014)
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Protein

SsrA-binding protein

Gene

smpB

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SsrA-binding proteinUniRule annotation
Alternative name(s):
Small protein BUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:smpBUniRule annotationImported
Synonyms:smpB_1Imported
ORF Names:C0094_17000Imported, DSI38_22440Imported, E5M05_07885Imported, E5M52_06370Imported, E5M78_06375Imported, ERS007657_00024Imported, ERS007661_00537Imported, ERS007663_02032Imported, ERS007665_00057Imported, ERS007670_00142Imported, ERS007679_03025Imported, ERS007720_01210Imported, ERS007722_01176Imported, ERS007741_01645Imported, ERS013471_02494Imported, ERS023446_02894Imported, ERS027646_02593Imported, ERS027661_03535Imported, ERS094182_02615Imported, F6W99_01728Imported, FRD82_02015Imported, GCL30_15290Imported, SAMEA2683035_03214Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000470375 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000298278 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000235535 Componenti: Chromosome
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotationARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SmpB family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09294, SmpB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.280.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00023, SmpB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023620, SmpB
IPR000037, SsrA-bd_prot
IPR020081, SsrA-bd_prot_CS

The PANTHER Classification System

More...
PANTHERi
PTHR30308, PTHR30308, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01668, SmpB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74982, SSF74982, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00086, smpB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01317, SSRP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045I136-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKSSRGGRQ IVASNRKARH NYSIIEVFEA GVALQGTEVK SLREGQASLA
60 70 80 90 100
DSFATIDDGE VWLRNAHIPE YRHGSWTNHE PRRNRKLLLH RRQIDTLVGK
110 120 130 140 150
IREGNFALVP LSLYFAEGKV KVELALARGK QARDKRQDMA RRDAQREVLR
160
ELGRRAKGMT
Length:160
Mass (Da):18,230
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i949F6327A03ACCD3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP84632.1
CGCX01000004 Genomic DNA Translation: CFR64306.1
CNFU01000948 Genomic DNA Translation: CKS79102.1
CNGE01000496 Genomic DNA Translation: CKS86568.1
CQGE01000074 Genomic DNA Translation: CNN30606.1
CQPL01000016 Genomic DNA Translation: CNT77272.1
CQPW01000004 Genomic DNA Translation: CNT93464.1
CQQC01000110 Genomic DNA Translation: CNU35892.1
CQPV01000283 Genomic DNA Translation: CNU90625.1
CQTT01000072 Genomic DNA Translation: CNY72828.1
CSAJ01000111 Genomic DNA Translation: COV92339.1
CSAM01000061 Genomic DNA Translation: COV94207.1
CSAD01000487 Genomic DNA Translation: COW06097.1
CHKL01000149 Genomic DNA Translation: COW15098.1
CVKR01000020 Genomic DNA Translation: CRF27164.1
WFLD01000020 Genomic DNA Translation: KAB7836528.1
CP044345 Genomic DNA Translation: QEX90936.1
QSXJ01001085 Genomic DNA Translation: REM61001.1
FPTZ01000027 Genomic DNA Translation: SGI27022.1
SRLJ01000011 Genomic DNA Translation: TGD78139.1
SRLK01000011 Genomic DNA Translation: TGD92790.1
SRLI01000013 Genomic DNA Translation: TGE04507.1
VOOQ01000033 Genomic DNA Translation: TXB95027.1

NCBI Reference Sequences

More...
RefSeqi
WP_003416113.1, NZ_WUJD01000045.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CKQ75240; CKQ75240; ERS027653_00026
CKQ92447; CKQ92447; ERS027644_00149
CKR27191; CKR27191; ERS027654_00989
CKR40324; CKR40324; ERS027656_01204
CKR82228; CKR82228; ERS027651_01530
CKS79102; CKS79102; ERS027661_03535
CKS86568; CKS86568; ERS027646_02593
CKU20626; CKU20626; ERS031537_00038
CNG57196; CNG57196; ERS124361_01271
CNN30606; CNN30606; ERS023446_02894
COV94207; COV94207; ERS007722_01176
COW15098; COW15098; ERS007741_01645
REM96237; REM96237; DSI35_27265
SGI27022; SGI27022; SAMEA2683035_03214
SGM65086; SGM65086; SAMEA2682864_02880

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45427099

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.550

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP025599 Genomic DNA Translation: AUP84632.1
CGCX01000004 Genomic DNA Translation: CFR64306.1
CNFU01000948 Genomic DNA Translation: CKS79102.1
CNGE01000496 Genomic DNA Translation: CKS86568.1
CQGE01000074 Genomic DNA Translation: CNN30606.1
CQPL01000016 Genomic DNA Translation: CNT77272.1
CQPW01000004 Genomic DNA Translation: CNT93464.1
CQQC01000110 Genomic DNA Translation: CNU35892.1
CQPV01000283 Genomic DNA Translation: CNU90625.1
CQTT01000072 Genomic DNA Translation: CNY72828.1
CSAJ01000111 Genomic DNA Translation: COV92339.1
CSAM01000061 Genomic DNA Translation: COV94207.1
CSAD01000487 Genomic DNA Translation: COW06097.1
CHKL01000149 Genomic DNA Translation: COW15098.1
CVKR01000020 Genomic DNA Translation: CRF27164.1
WFLD01000020 Genomic DNA Translation: KAB7836528.1
CP044345 Genomic DNA Translation: QEX90936.1
QSXJ01001085 Genomic DNA Translation: REM61001.1
FPTZ01000027 Genomic DNA Translation: SGI27022.1
SRLJ01000011 Genomic DNA Translation: TGD78139.1
SRLK01000011 Genomic DNA Translation: TGD92790.1
SRLI01000013 Genomic DNA Translation: TGE04507.1
VOOQ01000033 Genomic DNA Translation: TXB95027.1
RefSeqiWP_003416113.1, NZ_WUJD01000045.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCKQ75240; CKQ75240; ERS027653_00026
CKQ92447; CKQ92447; ERS027644_00149
CKR27191; CKR27191; ERS027654_00989
CKR40324; CKR40324; ERS027656_01204
CKR82228; CKR82228; ERS027651_01530
CKS79102; CKS79102; ERS027661_03535
CKS86568; CKS86568; ERS027646_02593
CKU20626; CKU20626; ERS031537_00038
CNG57196; CNG57196; ERS124361_01271
CNN30606; CNN30606; ERS023446_02894
COV94207; COV94207; ERS007722_01176
COW15098; COW15098; ERS007741_01645
REM96237; REM96237; DSI35_27265
SGI27022; SGI27022; SAMEA2683035_03214
SGM65086; SGM65086; SAMEA2682864_02880
GeneIDi45427099
PATRICifig|1773.206.peg.550

Family and domain databases

CDDicd09294, SmpB, 1 hit
Gene3Di2.40.280.10, 1 hit
HAMAPiMF_00023, SmpB, 1 hit
InterProiView protein in InterPro
IPR023620, SmpB
IPR000037, SsrA-bd_prot
IPR020081, SsrA-bd_prot_CS
PANTHERiPTHR30308, PTHR30308, 1 hit
PfamiView protein in Pfam
PF01668, SmpB, 1 hit
SUPFAMiSSF74982, SSF74982, 1 hit
TIGRFAMsiTIGR00086, smpB, 1 hit
PROSITEiView protein in PROSITE
PS01317, SSRP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045I136_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045I136
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 2, 2021
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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