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UniProtKB - A0A045HU02 (A0A045HU02_MYCTX)

Entry version 66 (07 Apr 2021)
Sequence version 1 (09 Jul 2014)
Previous versions | rss
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Protein
Submitted name:

Alternative RNA polymerase sigma factor SIGK

Gene

sigK

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation, Sigma factorARBA annotation
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alternative RNA polymerase sigma factor SIGKImported
Submitted name:
ECF RNA polymerase sigma factor SigKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sigKImported
ORF Names:DSI38_10960Imported, E5M05_01500Imported, E5M52_01735Imported, E5M78_01735Imported, ERS007657_01107Imported, ERS007661_00706Imported, ERS007663_01690Imported, ERS007670_01761Imported, ERS007679_03537Imported, ERS007681_01010Imported, ERS007688_03231Imported, ERS007720_02160Imported, ERS007722_02929Imported, ERS007741_01743Imported, ERS013471_02438Imported, ERS023446_00614Imported, ERS027646_02299Imported, ERS094182_00241Imported, F6W99_03100Imported, FRD82_01855Imported, GCL30_07845Imported, SAMEA2683035_00918Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000470375 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000298278 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 96Sigma70_r2InterPro annotationAdd BLAST68
Domaini133 – 182Sigma70_r4InterPro annotationAdd BLAST50

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sigma-70 factor family. ECF subfamily.ARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039425, RNA_pol_sigma-70-like
IPR014284, RNA_pol_sigma-70_dom
IPR007627, RNA_pol_sigma70_r2
IPR007630, RNA_pol_sigma70_r4
IPR013325, RNA_pol_sigma_r2
IPR013324, RNA_pol_sigma_r3/r4-like
IPR036388, WH-like_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR43133, PTHR43133, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04542, Sigma70_r2, 1 hit
PF04545, Sigma70_r4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF88659, SSF88659, 1 hit
SSF88946, SSF88946, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02937, sigma70-ECF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045HU02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGPPRLSSD LDALLRRVAG HDQAAFAEFY DHTKSRVYGL VMRVLRDTGY 
        60         70         80         90        100
SEETTQEIYL EVWRNASEFD SAKGSALAWL LTMAHRRAVD RVRCEQAGNQ 
       110        120        130        140        150
REVRYGAANV DPASDVVADL AIAGDERRRV TECLKALTDT QRQCIELAYY 
       160        170        180 
GGLTYVEVSR RLAANLSTIK SRMRDALRSL RNCLDVS
Length:187
Mass (Da):21,035
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2156CEB813620F02
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CFOE01000088 Genomic DNA Translation: CFE38458.1
CFOH01000664 Genomic DNA Translation: CFE65003.1
CGCX01000311 Genomic DNA Translation: CFR72523.1
CNGE01000408 Genomic DNA Translation: CKS68899.1
CQGE01000008 Genomic DNA Translation: CNM54333.1
CQQC01000154 Genomic DNA Translation: CNU46038.1
CQPL01000308 Genomic DNA Translation: CNU60817.1
CQPV01000219 Genomic DNA Translation: CNU71586.1
CQTT01000069 Genomic DNA Translation: CNY71063.1
CHKL01000163 Genomic DNA Translation: COW18290.1
CSAJ01000260 Genomic DNA Translation: COW25960.1
CSAD01000665 Genomic DNA Translation: COW27897.1
CSAM01000254 Genomic DNA Translation: COW53193.1
CVKR01000002 Genomic DNA Translation: CRF24830.1
WFLD01000007 Genomic DNA Translation: KAB7839749.1
CP044345 Genomic DNA Translation: QEX92293.1
QSXJ01000736 Genomic DNA Translation: REM67492.1
FPTZ01000004 Genomic DNA Translation: SGH34476.1
SRLJ01000002 Genomic DNA Translation: TGD82156.1
SRLK01000002 Genomic DNA Translation: TGD94171.1
SRLI01000002 Genomic DNA Translation: TGE07413.1
VOOQ01000030 Genomic DNA Translation: TXB95060.1

NCBI Reference Sequences

More...RefSeqi		WP_003402246.1, NZ_WUJD01000004.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		CKR06007; CKR06007; ERS027653_00586
CKR75490; CKR75490; ERS027644_02017
CKR91355; CKR91355; ERS027651_01730
CKS50939; CKS50939; ERS027654_03353
CKS68899; CKS68899; ERS027646_02299
CKS87777; CKS87777; ERS027656_03577
CKV06252; CKV06252; ERS031537_01851
CNG07426; CNG07426; ERS124361_00109
CNM54333; CNM54333; ERS023446_00614
COW18290; COW18290; ERS007741_01743
COW53193; COW53193; ERS007722_02929
REM95915; REM95915; DSI35_28025
SGH34476; SGH34476; SAMEA2683035_00918
SGL67214; SGL67214; SAMEA2682864_01079

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1773.206.peg.4120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000088 Genomic DNA Translation: CFE38458.1
CFOH01000664 Genomic DNA Translation: CFE65003.1
CGCX01000311 Genomic DNA Translation: CFR72523.1
CNGE01000408 Genomic DNA Translation: CKS68899.1
CQGE01000008 Genomic DNA Translation: CNM54333.1
CQQC01000154 Genomic DNA Translation: CNU46038.1
CQPL01000308 Genomic DNA Translation: CNU60817.1
CQPV01000219 Genomic DNA Translation: CNU71586.1
CQTT01000069 Genomic DNA Translation: CNY71063.1
CHKL01000163 Genomic DNA Translation: COW18290.1
CSAJ01000260 Genomic DNA Translation: COW25960.1
CSAD01000665 Genomic DNA Translation: COW27897.1
CSAM01000254 Genomic DNA Translation: COW53193.1
CVKR01000002 Genomic DNA Translation: CRF24830.1
WFLD01000007 Genomic DNA Translation: KAB7839749.1
CP044345 Genomic DNA Translation: QEX92293.1
QSXJ01000736 Genomic DNA Translation: REM67492.1
FPTZ01000004 Genomic DNA Translation: SGH34476.1
SRLJ01000002 Genomic DNA Translation: TGD82156.1
SRLK01000002 Genomic DNA Translation: TGD94171.1
SRLI01000002 Genomic DNA Translation: TGE07413.1
VOOQ01000030 Genomic DNA Translation: TXB95060.1
RefSeqiWP_003402246.1, NZ_WUJD01000004.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiCKR06007; CKR06007; ERS027653_00586
CKR75490; CKR75490; ERS027644_02017
CKR91355; CKR91355; ERS027651_01730
CKS50939; CKS50939; ERS027654_03353
CKS68899; CKS68899; ERS027646_02299
CKS87777; CKS87777; ERS027656_03577
CKV06252; CKV06252; ERS031537_01851
CNG07426; CNG07426; ERS124361_00109
CNM54333; CNM54333; ERS023446_00614
COW18290; COW18290; ERS007741_01743
COW53193; COW53193; ERS007722_02929
REM95915; REM95915; DSI35_28025
SGH34476; SGH34476; SAMEA2683035_00918
SGL67214; SGL67214; SAMEA2682864_01079
PATRICifig|1773.206.peg.4120

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR039425, RNA_pol_sigma-70-like
IPR014284, RNA_pol_sigma-70_dom
IPR007627, RNA_pol_sigma70_r2
IPR007630, RNA_pol_sigma70_r4
IPR013325, RNA_pol_sigma_r2
IPR013324, RNA_pol_sigma_r3/r4-like
IPR036388, WH-like_DNA-bd_sf
PANTHERiPTHR43133, PTHR43133, 1 hit
PfamiView protein in Pfam
PF04542, Sigma70_r2, 1 hit
PF04545, Sigma70_r4, 1 hit
SUPFAMiSSF88659, SSF88659, 1 hit
SSF88946, SSF88946, 1 hit
TIGRFAMsiTIGR02937, sigma70-ECF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045HU02_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045HU02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: April 7, 2021
This is version 66 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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