Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 64 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ribonuclease VapC

Gene

vapC11

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Toxic component of a toxin-antitoxin (TA) system. An RNase.UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5MagnesiumUniRule annotation1
Metal bindingi98MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotationARBA annotation, ToxinUniRule annotation
Biological processToxin-antitoxin systemUniRule annotationARBA annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease VapCUniRule annotation (EC:3.1.-.-UniRule annotation)
Short name:
RNase VapCUniRule annotation
Alternative name(s):
Toxin VapCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vapC11Imported
Synonyms:vapCUniRule annotation
ORF Names:DSI38_14850Imported, E5M52_02610Imported, ERS007657_00583Imported, ERS007661_00773Imported, ERS007663_00058Imported, ERS007665_00095Imported, ERS007670_01294Imported, ERS007679_02029Imported, ERS007681_00162Imported, ERS007688_02673Imported, ERS007703_02348Imported, ERS007720_03902Imported, ERS007722_03216Imported, ERS007741_00106Imported, ERS013471_00968Imported, ERS023446_01347Imported, ERS024276_02275Imported, ERS027646_03019Imported, ERS027659_02661Imported, ERS027661_01763Imported, ERS075361_00094Imported, ERS094182_01467Imported, F6W99_00120Imported, F9908_17125Imported, SAMEA2683035_03188Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000041288 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000039217 Componenti: Unassembled WGS sequence
  • UP000431688 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000045274 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 124PINcInterPro annotationAdd BLAST123

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PINc/VapC protein family.UniRule annotation

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00265, VapC_Nob1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029060, PIN-like_dom_sf
IPR002716, PIN_dom
IPR022907, VapC_family

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01850, PIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88723, SSF88723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045HJR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILIDTSAWV EYFRATGSIA AVEVRRLLSE EAARIAMCEP IAMEILSGAL
60 70 80 90 100
DDNTHTTLER LVNGLPSLNV DDAIDFRAAA GIYRAARRAG ETVRSINDCL
110 120 130
IAALAIRHGA RIVHRDADFD VIARITNLQA ASFR
Length:134
Mass (Da):14,651
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D22BA3A94DE0FEB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000010 Genomic DNA Translation: CFE34851.1
CFOH01000475 Genomic DNA Translation: CFE58170.1
CGCX01000131 Genomic DNA Translation: CFR67940.1
CNCN01000583 Genomic DNA Translation: CKO99295.1
CNFU01000321 Genomic DNA Translation: CKR61545.1
CNFT01000664 Genomic DNA Translation: CKS11586.1
CNGE01000638 Genomic DNA Translation: CKT12422.1
CQAC01000001 Genomic DNA Translation: CNF95939.1
CQGE01000021 Genomic DNA Translation: CNM81821.1
CQPV01000004 Genomic DNA Translation: CNT89469.1
CQPW01000008 Genomic DNA Translation: CNT95177.1
CQPL01000198 Genomic DNA Translation: CNU32392.1
CQQC01000171 Genomic DNA Translation: CNU50320.1
CQTT01000016 Genomic DNA Translation: CNY25146.1
CHKL01000005 Genomic DNA Translation: COV53131.1
CSAD01000253 Genomic DNA Translation: COV53790.1
CSAE01000249 Genomic DNA Translation: COV93876.1
CSAM01000302 Genomic DNA Translation: COW67818.1
CSAJ01000707 Genomic DNA Translation: COX09683.1
CVKR01000009 Genomic DNA Translation: CRF26033.1
WFKV01000023 Genomic DNA Translation: KAB7800265.1
CP044345 Genomic DNA Translation: QEX89349.1
QSXJ01001014 Genomic DNA Translation: REM65032.1
FPTZ01000026 Genomic DNA Translation: SGI25590.1
SRLJ01000004 Genomic DNA Translation: TGD81048.1

NCBI Reference Sequences

More...
RefSeqi
WP_003407786.1, NZ_WUJD01000015.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC45945; AMC45945; RN05_1669
CFE34851; CFE34851; ERS007681_00162
CFE58170; CFE58170; ERS007688_02673
CFR67940; CFR67940; ERS007657_00583
CKO99295; CKO99295; ERS024276_02275
CKP69264; CKP69264; ERS024213_02551
CKQ82608; CKQ82608; ERS027656_00048
CKR26141; CKR26141; ERS027653_00962
CKR37616; CKR37616; ERS027644_01092
CKR61545; CKR61545; ERS027661_01763
CKS11586; CKS11586; ERS027659_02661
CKS40873; CKS40873; ERS027652_03155
CKS49802; CKS49802; ERS027654_03336
CKT12422; CKT12422; ERS027646_03019
CKT57457; CKT57457; ERS027666_03063
CKV36551; CKV36551; ERS031537_02602
CNG13486; CNG13486; ERS124361_00265
CNM81821; CNM81821; ERS023446_01347
CNT89469; CNT89469; ERS007663_00058
CNT95177; CNT95177; ERS007665_00095
CNU32392; CNU32392; ERS007670_01294
CNU50320; CNU50320; ERS007661_00773
CNY25146; CNY25146; ERS013471_00968
COV53131; COV53131; ERS007741_00106
COV53790; COV53790; ERS007679_02029
COV93876; COV93876; ERS007703_02348
COW09751; COW09751; ERS007672_03015
COW67818; COW67818; ERS007722_03216
COW77324; COW77324; ERS007739_00037
COX09683; COX09683; ERS007720_03902
CRH12191; CRH12191; BN1303_01477
CRH14774; CRH14774; BN1213_02962

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23492273

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.1347

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000010 Genomic DNA Translation: CFE34851.1
CFOH01000475 Genomic DNA Translation: CFE58170.1
CGCX01000131 Genomic DNA Translation: CFR67940.1
CNCN01000583 Genomic DNA Translation: CKO99295.1
CNFU01000321 Genomic DNA Translation: CKR61545.1
CNFT01000664 Genomic DNA Translation: CKS11586.1
CNGE01000638 Genomic DNA Translation: CKT12422.1
CQAC01000001 Genomic DNA Translation: CNF95939.1
CQGE01000021 Genomic DNA Translation: CNM81821.1
CQPV01000004 Genomic DNA Translation: CNT89469.1
CQPW01000008 Genomic DNA Translation: CNT95177.1
CQPL01000198 Genomic DNA Translation: CNU32392.1
CQQC01000171 Genomic DNA Translation: CNU50320.1
CQTT01000016 Genomic DNA Translation: CNY25146.1
CHKL01000005 Genomic DNA Translation: COV53131.1
CSAD01000253 Genomic DNA Translation: COV53790.1
CSAE01000249 Genomic DNA Translation: COV93876.1
CSAM01000302 Genomic DNA Translation: COW67818.1
CSAJ01000707 Genomic DNA Translation: COX09683.1
CVKR01000009 Genomic DNA Translation: CRF26033.1
WFKV01000023 Genomic DNA Translation: KAB7800265.1
CP044345 Genomic DNA Translation: QEX89349.1
QSXJ01001014 Genomic DNA Translation: REM65032.1
FPTZ01000026 Genomic DNA Translation: SGI25590.1
SRLJ01000004 Genomic DNA Translation: TGD81048.1
RefSeqiWP_003407786.1, NZ_WUJD01000015.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC45945; AMC45945; RN05_1669
CFE34851; CFE34851; ERS007681_00162
CFE58170; CFE58170; ERS007688_02673
CFR67940; CFR67940; ERS007657_00583
CKO99295; CKO99295; ERS024276_02275
CKP69264; CKP69264; ERS024213_02551
CKQ82608; CKQ82608; ERS027656_00048
CKR26141; CKR26141; ERS027653_00962
CKR37616; CKR37616; ERS027644_01092
CKR61545; CKR61545; ERS027661_01763
CKS11586; CKS11586; ERS027659_02661
CKS40873; CKS40873; ERS027652_03155
CKS49802; CKS49802; ERS027654_03336
CKT12422; CKT12422; ERS027646_03019
CKT57457; CKT57457; ERS027666_03063
CKV36551; CKV36551; ERS031537_02602
CNG13486; CNG13486; ERS124361_00265
CNM81821; CNM81821; ERS023446_01347
CNT89469; CNT89469; ERS007663_00058
CNT95177; CNT95177; ERS007665_00095
CNU32392; CNU32392; ERS007670_01294
CNU50320; CNU50320; ERS007661_00773
CNY25146; CNY25146; ERS013471_00968
COV53131; COV53131; ERS007741_00106
COV53790; COV53790; ERS007679_02029
COV93876; COV93876; ERS007703_02348
COW09751; COW09751; ERS007672_03015
COW67818; COW67818; ERS007722_03216
COW77324; COW77324; ERS007739_00037
COX09683; COX09683; ERS007720_03902
CRH12191; CRH12191; BN1303_01477
CRH14774; CRH14774; BN1213_02962
GeneIDi23492273
PATRICifig|1773.206.peg.1347

Family and domain databases

HAMAPiMF_00265, VapC_Nob1, 1 hit
InterProiView protein in InterPro
IPR029060, PIN-like_dom_sf
IPR002716, PIN_dom
IPR022907, VapC_family
PfamiView protein in Pfam
PF01850, PIN, 1 hit
SUPFAMiSSF88723, SSF88723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045HJR7_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045HJR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again