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Entry version 62 (12 Aug 2020)
Sequence version 1 (09 Jul 2014)
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Protein

Ribonuclease VapC

Gene

vapC3_3

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Toxic component of a toxin-antitoxin (TA) system. An RNase.UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationARBA annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi5MagnesiumUniRule annotation1
Metal bindingi91MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotationARBA annotation, ToxinUniRule annotation
Biological processToxin-antitoxin systemUniRule annotationARBA annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease VapCUniRule annotation (EC:3.1.-.-UniRule annotation)
Short name:
RNase VapCUniRule annotation
Alternative name(s):
Toxin VapCUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vapC3_3Imported
Synonyms:vapCUniRule annotation, vapC3_1Imported, vapC3_2Imported, vapC3_4Imported, vapC9Imported
ORF Names:DSI38_18975Imported, E5M52_02450Imported, ERS007657_01854Imported, ERS007670_01993Imported, ERS007679_01393Imported, ERS007681_01445Imported, ERS007688_02157Imported, ERS007703_01498Imported, ERS007720_02214Imported, ERS007722_03689Imported, ERS007741_00987Imported, ERS013471_03038Imported, ERS023446_00862Imported, ERS024276_02857Imported, ERS027646_02038Imported, ERS027661_00830Imported, ERS075361_01044Imported, ERS094182_02854Imported, F6W99_03657Imported, F9908_09555Imported, FRD82_15950Imported, SAMEA2683035_04098Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000297584 Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000041288 Componenti: Unassembled WGS sequence
  • UP000431688 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000046947 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000046680 Componenti: Unassembled WGS sequence
  • UP000038802 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000044938 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 115PINcInterPro annotationAdd BLAST114

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PINc/VapC protein family.UniRule annotation

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00265, VapC_Nob1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029060, PIN-like_dom_sf
IPR002716, PIN_dom
IPR022907, VapC_family

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01850, PIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88723, SSF88723, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045H7X4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVVDASAAL AALLNDGQAR QLIAAERLHV PHLVDSEIAS GLRRLAQRDR
60 70 80 90 100
LGAADGRRAL QTWRRLAVTR YPVVGLFERI WEIRANLSAY DASYVALAEA
110 120
LNCALVTADL RLSDTGQAQC PITVVPR
Length:127
Mass (Da):13,859
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6804DC5EE9269AC0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000146 Genomic DNA Translation: CFE39073.1
CFOH01000334 Genomic DNA Translation: CFE52784.1
CGCX01000635 Genomic DNA Translation: CFR80610.1
CNCN01000854 Genomic DNA Translation: CKP44361.1
CNFU01000117 Genomic DNA Translation: CKR22864.1
CNGE01000346 Genomic DNA Translation: CKS53817.1
CQAC01000005 Genomic DNA Translation: CNG33561.1
CQGE01000012 Genomic DNA Translation: CNM63502.1
CQPL01000372 Genomic DNA Translation: CNU76450.1
CQTT01000103 Genomic DNA Translation: CNY90810.1
CSAD01000146 Genomic DNA Translation: COV23935.1
CSAE01000127 Genomic DNA Translation: COV48914.1
CHKL01000072 Genomic DNA Translation: COV93221.1
CSAJ01000269 Genomic DNA Translation: COW27681.1
CSAM01000405 Genomic DNA Translation: COW90115.1
CVKR01000022 Genomic DNA Translation: CRF27394.1
WFKV01000009 Genomic DNA Translation: KAB7804738.1
CP044345 Genomic DNA Translation: QEX92839.1
QSXJ01001050 Genomic DNA Translation: REM62899.1
FPTZ01000053 Genomic DNA Translation: SGI66994.1
SRLJ01000003 Genomic DNA Translation: TGD82041.1
VOOQ01000532 Genomic DNA Translation: TXB92411.1

NCBI Reference Sequences

More...
RefSeqi
WP_003404903.1, NZ_WUJD01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC45297; AMC45297; RN05_1021
CFE39073; CFE39073; ERS007681_01445
CFE52784; CFE52784; ERS007688_02157
CFR80610; CFR80610; ERS007657_01854
CKP44361; CKP44361; ERS024276_02857
CKQ43567; CKQ43567; ERS024213_03690
CKR22864; CKR22864; ERS027661_00830
CKR35047; CKR35047; ERS027652_01209
CKR55462; CKR55462; ERS027644_01545
CKR62443; CKR62443; ERS027653_01779
CKR71895; CKR71895; ERS027654_02088
CKS33310; CKS33310; ERS027666_00879
CKS53817; CKS53817; ERS027646_02038
CKS76562; CKS76562; ERS027656_03436
CKW87961; CKW87961; ERS031537_04693
CNH15397; CNH15397; ERS124361_02974
CNM63502; CNM63502; ERS023446_00862
CNU76450; CNU76450; ERS007670_01993
CNY90810; CNY90810; ERS013471_03038
COV05726; COV05726; ERS007672_00940
COV23935; COV23935; ERS007679_01393
COV48914; COV48914; ERS007703_01498
COV93221; COV93221; ERS007741_00987
COW27681; COW27681; ERS007720_02214
COW90115; COW90115; ERS007722_03689
COX19704; COX19704; ERS007731_01599
COX50065; COX50065; ERS007739_01380
CRH13272; CRH13272; BN1213_02231
CRH13536; CRH13536; BN1303_02153

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23492912

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.3632

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000146 Genomic DNA Translation: CFE39073.1
CFOH01000334 Genomic DNA Translation: CFE52784.1
CGCX01000635 Genomic DNA Translation: CFR80610.1
CNCN01000854 Genomic DNA Translation: CKP44361.1
CNFU01000117 Genomic DNA Translation: CKR22864.1
CNGE01000346 Genomic DNA Translation: CKS53817.1
CQAC01000005 Genomic DNA Translation: CNG33561.1
CQGE01000012 Genomic DNA Translation: CNM63502.1
CQPL01000372 Genomic DNA Translation: CNU76450.1
CQTT01000103 Genomic DNA Translation: CNY90810.1
CSAD01000146 Genomic DNA Translation: COV23935.1
CSAE01000127 Genomic DNA Translation: COV48914.1
CHKL01000072 Genomic DNA Translation: COV93221.1
CSAJ01000269 Genomic DNA Translation: COW27681.1
CSAM01000405 Genomic DNA Translation: COW90115.1
CVKR01000022 Genomic DNA Translation: CRF27394.1
WFKV01000009 Genomic DNA Translation: KAB7804738.1
CP044345 Genomic DNA Translation: QEX92839.1
QSXJ01001050 Genomic DNA Translation: REM62899.1
FPTZ01000053 Genomic DNA Translation: SGI66994.1
SRLJ01000003 Genomic DNA Translation: TGD82041.1
VOOQ01000532 Genomic DNA Translation: TXB92411.1
RefSeqiWP_003404903.1, NZ_WUJD01000008.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC45297; AMC45297; RN05_1021
CFE39073; CFE39073; ERS007681_01445
CFE52784; CFE52784; ERS007688_02157
CFR80610; CFR80610; ERS007657_01854
CKP44361; CKP44361; ERS024276_02857
CKQ43567; CKQ43567; ERS024213_03690
CKR22864; CKR22864; ERS027661_00830
CKR35047; CKR35047; ERS027652_01209
CKR55462; CKR55462; ERS027644_01545
CKR62443; CKR62443; ERS027653_01779
CKR71895; CKR71895; ERS027654_02088
CKS33310; CKS33310; ERS027666_00879
CKS53817; CKS53817; ERS027646_02038
CKS76562; CKS76562; ERS027656_03436
CKW87961; CKW87961; ERS031537_04693
CNH15397; CNH15397; ERS124361_02974
CNM63502; CNM63502; ERS023446_00862
CNU76450; CNU76450; ERS007670_01993
CNY90810; CNY90810; ERS013471_03038
COV05726; COV05726; ERS007672_00940
COV23935; COV23935; ERS007679_01393
COV48914; COV48914; ERS007703_01498
COV93221; COV93221; ERS007741_00987
COW27681; COW27681; ERS007720_02214
COW90115; COW90115; ERS007722_03689
COX19704; COX19704; ERS007731_01599
COX50065; COX50065; ERS007739_01380
CRH13272; CRH13272; BN1213_02231
CRH13536; CRH13536; BN1303_02153
GeneIDi23492912
PATRICifig|1773.206.peg.3632

Family and domain databases

HAMAPiMF_00265, VapC_Nob1, 1 hit
InterProiView protein in InterPro
IPR029060, PIN-like_dom_sf
IPR002716, PIN_dom
IPR022907, VapC_family
PfamiView protein in Pfam
PF01850, PIN, 1 hit
SUPFAMiSSF88723, SSF88723, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045H7X4_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045H7X4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: August 12, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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