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Entry version 62 (17 Jun 2020)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Alpha/beta fold hydrolase

Gene

ephA

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha/beta fold hydrolaseImported
Submitted name:
Alpha/beta hydrolaseImported
Submitted name:
Epoxide hydrolase EphAImported
Submitted name:
Putative epoxide hydrolase EPHAImported (EC:3.3.2.10Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ephAImported
ORF Names:AYJ03_019090Imported, DSI38_17955Imported, E5M05_20865Imported, ERS007679_03409Imported, ERS007681_03435Imported, ERS007722_03890Imported, ERS013471_03193Imported, ERS023446_03876Imported, ERS027646_02720Imported, ERS027659_01885Imported, ERS027661_01688Imported, ERS075361_04034Imported, ERS094182_04071Imported, F6W99_02293Imported, FRD82_05300Imported, GJE03_19000Imported, SAMEA2683035_00712Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000321489 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000048948 Componenti: Unassembled WGS sequence
  • UP000256245 Componenti: Unassembled WGS sequence
  • UP000045842 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000048289 Componenti: Unassembled WGS sequence
  • UP000075723 Componenti: Chromosome
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000042440 Componenti: Unassembled WGS sequence
  • UP000326088 Componenti: Chromosome
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000388593 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 131AB hydrolase-1InterPro annotationAdd BLAST105

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105D74 Bacteria
ENOG410XVV6 LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00561 Abhydrolase_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00412 EPOXHYDRLASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045H6J6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAPTERLVD TNGVRLRVVE AGEPGAPVVI LAHGFPELAY SWRHQIPALA
60 70 80 90 100
DAGYHVLAPD QRGYGGSSRP EAIEAYDIHR LTADLVGLLD DVGAERAVWV
110 120 130 140 150
GHDWGAVVVW NAPLLHADRV AAVAALSVPA LPRAQVPPTQ AFRSRFGENF
160 170 180 190 200
FYILYFQEPG IADAELNGDP ARTMRRMIGG LRPPGDQSAA MRMLAPGPDG
210 220 230 240 250
FIDRLPEPAG LPAWISQEEL DHYIGEFTRT GFTGGLNWYR NFDRNWETTA
260 270 280 290 300
DLAGKTISVP SLFIAGTADP VLTFTRTDRA AEVISGPYRE VLIDGAGHWL
310 320
QQERPGEVTA ALLEFLTGLE LR
Length:322
Mass (Da):35,097
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA270066838AF442
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000594 Genomic DNA Translation: CFE43540.1
CNFU01000304 Genomic DNA Translation: CKR58567.1
CNFT01000391 Genomic DNA Translation: CKR63210.1
CNGE01000540 Genomic DNA Translation: CKS94633.1
CQAC01000053 Genomic DNA Translation: CNH41903.1
CQGE01000156 Genomic DNA Translation: CNN55138.1
CQTT01000114 Genomic DNA Translation: CNY96808.1
CSAD01000615 Genomic DNA Translation: COW22288.1
CSAM01000462 Genomic DNA Translation: COW99339.1
CVKR01000058 Genomic DNA Translation: CRF28575.1
CP044345 Genomic DNA Translation: QEX91498.1
CP045962 Genomic DNA Translation: QGK80704.1
CP046529 Genomic DNA Translation: QGV23185.1
QSXJ01001043 Genomic DNA Translation: REM63252.1
FPTZ01000003 Genomic DNA Translation: SGH26242.1
SRLI01000075 Genomic DNA Translation: TGD96669.1
VOOQ01000110 Genomic DNA Translation: TXB94401.1

NCBI Reference Sequences

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RefSeqi
WP_003899600.1, NZ_WJSJ01000037.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC48129; AMC48129; RN05_3853
CFE43540; CFE43540; ERS007681_03435
CKR00703; CKR00703; ERS027654_00475
CKR20265; CKR20265; ERS027653_00847
CKR58567; CKR58567; ERS027661_01688
CKR63210; CKR63210; ERS027659_01885
CKS94633; CKS94633; ERS027646_02720
CKU69551; CKU69551; ERS031537_01073
CNI34386; CNI34386; ERS124361_05408
CNN55138; CNN55138; ERS023446_03876
CNY96808; CNY96808; ERS013471_03193
COW22288; COW22288; ERS007679_03409
COW99339; COW99339; ERS007722_03890
CRH10313; CRH10313; BN1213_00634
CRH16971; CRH16971; BN1303_03961

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.3929

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000594 Genomic DNA Translation: CFE43540.1
CNFU01000304 Genomic DNA Translation: CKR58567.1
CNFT01000391 Genomic DNA Translation: CKR63210.1
CNGE01000540 Genomic DNA Translation: CKS94633.1
CQAC01000053 Genomic DNA Translation: CNH41903.1
CQGE01000156 Genomic DNA Translation: CNN55138.1
CQTT01000114 Genomic DNA Translation: CNY96808.1
CSAD01000615 Genomic DNA Translation: COW22288.1
CSAM01000462 Genomic DNA Translation: COW99339.1
CVKR01000058 Genomic DNA Translation: CRF28575.1
CP044345 Genomic DNA Translation: QEX91498.1
CP045962 Genomic DNA Translation: QGK80704.1
CP046529 Genomic DNA Translation: QGV23185.1
QSXJ01001043 Genomic DNA Translation: REM63252.1
FPTZ01000003 Genomic DNA Translation: SGH26242.1
SRLI01000075 Genomic DNA Translation: TGD96669.1
VOOQ01000110 Genomic DNA Translation: TXB94401.1
RefSeqiWP_003899600.1, NZ_WJSJ01000037.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC48129; AMC48129; RN05_3853
CFE43540; CFE43540; ERS007681_03435
CKR00703; CKR00703; ERS027654_00475
CKR20265; CKR20265; ERS027653_00847
CKR58567; CKR58567; ERS027661_01688
CKR63210; CKR63210; ERS027659_01885
CKS94633; CKS94633; ERS027646_02720
CKU69551; CKU69551; ERS031537_01073
CNI34386; CNI34386; ERS124361_05408
CNN55138; CNN55138; ERS023446_03876
CNY96808; CNY96808; ERS013471_03193
COW22288; COW22288; ERS007679_03409
COW99339; COW99339; ERS007722_03890
CRH10313; CRH10313; BN1213_00634
CRH16971; CRH16971; BN1303_03961
PATRICifig|1773.206.peg.3929

Phylogenomic databases

eggNOGiENOG4105D74 Bacteria
ENOG410XVV6 LUCA

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR000639 Epox_hydrolase-like
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
PRINTSiPR00412 EPOXHYDRLASE
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045H6J6_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045H6J6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 17, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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