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Entry version 58 (13 Nov 2019)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

GTP pyrophosphokinase

Gene

relA

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GTP pyrophosphokinaseImported (EC:2.7.6.5Imported)
Submitted name:
RelA/SpoT family proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:relAImported
Synonyms:relA_1Imported, relA_2Imported
ORF Names:DSI35_04165Imported, ERS007670_00394Imported, ERS007672_02061Imported, ERS007679_01443Imported, ERS007681_01023Imported, ERS007720_03265Imported, ERS007722_00382Imported, ERS007741_01829Imported, ERS023446_01042Imported, ERS027644_00377Imported, ERS027651_02630Imported, ERS027653_01355Imported, ERS027661_01493Imported, ERS031537_00470Imported, ERS124361_00354Imported, EZX46_13525Imported, FDK60_14475Imported, SAMEA2682835_04472Imported, SAMEA2682864_02506Imported, SAMEA2683035_01876Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000049498 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000256252 Componenti: Unassembled WGS sequence
  • UP000298273 Componenti: Unassembled WGS sequence
  • UP000047075 Componenti: Unassembled WGS sequence
  • UP000298647 Componenti: Unassembled WGS sequence
  • UP000043293 Componenti: Unassembled WGS sequence
  • UP000049023 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000183655 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000305204 Componenti: Unassembled WGS sequence
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000049114 Componenti: Unassembled WGS sequence
  • UP000050038 Componenti: Unassembled WGS sequence
  • UP000049058 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini105 – 202HDInterPro annotationAdd BLAST98
Domaini714 – 788ACTInterPro annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni620 – 644DisorderedSequence analysisAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the relA/spoT family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CWR Bacteria
COG0317 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00077 HDc, 1 hit
cd05399 NT_Rel-Spo_like, 1 hit
cd01668 TGS_RSH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002912 ACT_dom
IPR012675 Beta-grasp_dom_sf
IPR003607 HD/PDEase_dom
IPR004811 RelA/Spo_fam
IPR007685 RelA_SpoT
IPR004095 TGS
IPR012676 TGS-like
IPR033655 TGS_RelA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13291 ACT_4, 1 hit
PF04607 RelA_SpoT, 1 hit
PF02824 TGS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00471 HDc, 1 hit
SM00954 RelA_SpoT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81271 SSF81271, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00691 spoT_relA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51671 ACT, 1 hit
PS51831 HD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045GTV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDQLTAQA VAPPTEASAA LEPALETPES PVETLKTSIS ASRRVRARLA
60 70 80 90 100
RRMTAQRSTT NPVLEPLVAV HREIYPKADL SILQRAYEVA DQRHASQLRQ
110 120 130 140 150
SGDPYITHPL AVANILAELG MDTTTLVAAL LHDTVEDTGY TLEALTEEFG
160 170 180 190 200
EEVGHLVDGV TKLDRVVLGS AAEGETIRKM ITAMARDPRV LVIKVADRLH
210 220 230 240 250
NMRTMRFLPP EKQARKARET LEVIAPLAHR LGMASVKWEL EDLSFAILHP
260 270 280 290 300
KKYEEIVRLV AGRAPSRDTY LAKVRAEIVN TLTASKIKAT VEGRPKHYWS
310 320 330 340 350
IYQKMIVKGR DFDDIHDLVG VRILCDEIRD CYAAVGVVHS LWQPMAGRFK
360 370 380 390 400
DYIAQPRYGV YQSLHTTVVG PEGKPLEVQI RTRDMHRTAE YGIAAHWRYK
410 420 430 440 450
EAKGRNGVLH PHAAAEIDDM AWMRQLLDWQ REAADPGEFL ESLRYDLAVQ
460 470 480 490 500
EIFVFTPKGD VITLPTGSTP VDFAYAVHTE VGHRCIGARV NGRLVALERK
510 520 530 540 550
LENGEVVEVF TSKAPNAGPS RDWQQFVVSP RAKTKIRQWF AKERREEALE
560 570 580 590 600
TGKDAMAREV RRGGLPLQRL VNGESMAAVA RELHYADVSA LYTAIGEGHV
610 620 630 640 650
SAKHVVQRLL AELGGIDQAE EELAERSTPA TMPRRPRSTD DVGVSVPGAP
660 670 680 690 700
GVLTKLAKCC TPVPGDVIMG FVTRGGGVSV HRTDCTNAAS LQQQAERIIE
710 720 730 740 750
VLWAPSPSSV FLVAIQVEAL DRHRLLSDVT RALADEKVNI LSASVTTSGD
760 770 780 790
RVAISRFTFE MGDPKHLGHL LNAVRNVEGV YDVYRVTSAA
Length:790
Mass (Da):87,354
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7A7E669241C0E299
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CFOE01000090 Genomic DNA Translation: CFE38500.1
CNFW01000036 Genomic DNA Translation: CKR03847.1
CNFS01000252 Genomic DNA Translation: CKR45623.1
CNFU01000256 Genomic DNA Translation: CKR50936.1
CIEA01000028 Genomic DNA Translation: CKS34602.1
CNIS01000042 Genomic DNA Translation: CKU41067.1
CHDS01000003 Genomic DNA Translation: CNG17369.1
CQGE01000015 Genomic DNA Translation: CNM70234.1
CQPL01000050 Genomic DNA Translation: CNT87630.1
CSAD01000154 Genomic DNA Translation: COV25984.1
CHEE01000349 Genomic DNA Translation: COV57728.1
CSAM01000014 Genomic DNA Translation: COV58942.1
CHKL01000176 Genomic DNA Translation: COW21054.1
CSAJ01000505 Genomic DNA Translation: COW78132.1
QSXG01000353 Genomic DNA Translation: REN15914.1
FPPU01000021 Genomic DNA Translation: SGD62656.1
FPTZ01000011 Genomic DNA Translation: SGH73451.1
FPXX01000015 Genomic DNA Translation: SGM48443.1
SMOE01000094 Genomic DNA Translation: TFB21243.1
SZTS01000050 Genomic DNA Translation: TKR38744.1

NCBI Reference Sequences

More...
RefSeqi
WP_003413368.1, NZ_VOVY01000013.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC47034; AMC47034; RN05_2758
CFE38500; CFE38500; ERS007681_01023
CKR03847; CKR03847; ERS027644_00377
CKR45623; CKR45623; ERS027653_01355
CKR50936; CKR50936; ERS027661_01493
CKU41067; CKU41067; ERS031537_00470
CNG17369; CNG17369; ERS124361_00354
CNM70234; CNM70234; ERS023446_01042
CNT87630; CNT87630; ERS007670_00394
CNY30503; CNY30503; ERS013471_01154
COV25984; COV25984; ERS007679_01443
COV57728; COV57728; ERS007672_02061
COV58942; COV58942; ERS007722_00382
COW21054; COW21054; ERS007741_01829
COW78132; COW78132; ERS007720_03265
CRH11638; CRH11638; BN1303_01233
CRH15132; CRH15132; BN1213_03150

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.206.peg.3024

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CFOE01000090 Genomic DNA Translation: CFE38500.1
CNFW01000036 Genomic DNA Translation: CKR03847.1
CNFS01000252 Genomic DNA Translation: CKR45623.1
CNFU01000256 Genomic DNA Translation: CKR50936.1
CIEA01000028 Genomic DNA Translation: CKS34602.1
CNIS01000042 Genomic DNA Translation: CKU41067.1
CHDS01000003 Genomic DNA Translation: CNG17369.1
CQGE01000015 Genomic DNA Translation: CNM70234.1
CQPL01000050 Genomic DNA Translation: CNT87630.1
CSAD01000154 Genomic DNA Translation: COV25984.1
CHEE01000349 Genomic DNA Translation: COV57728.1
CSAM01000014 Genomic DNA Translation: COV58942.1
CHKL01000176 Genomic DNA Translation: COW21054.1
CSAJ01000505 Genomic DNA Translation: COW78132.1
QSXG01000353 Genomic DNA Translation: REN15914.1
FPPU01000021 Genomic DNA Translation: SGD62656.1
FPTZ01000011 Genomic DNA Translation: SGH73451.1
FPXX01000015 Genomic DNA Translation: SGM48443.1
SMOE01000094 Genomic DNA Translation: TFB21243.1
SZTS01000050 Genomic DNA Translation: TKR38744.1
RefSeqiWP_003413368.1, NZ_VOVY01000013.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC47034; AMC47034; RN05_2758
CFE38500; CFE38500; ERS007681_01023
CKR03847; CKR03847; ERS027644_00377
CKR45623; CKR45623; ERS027653_01355
CKR50936; CKR50936; ERS027661_01493
CKU41067; CKU41067; ERS031537_00470
CNG17369; CNG17369; ERS124361_00354
CNM70234; CNM70234; ERS023446_01042
CNT87630; CNT87630; ERS007670_00394
CNY30503; CNY30503; ERS013471_01154
COV25984; COV25984; ERS007679_01443
COV57728; COV57728; ERS007672_02061
COV58942; COV58942; ERS007722_00382
COW21054; COW21054; ERS007741_01829
COW78132; COW78132; ERS007720_03265
CRH11638; CRH11638; BN1303_01233
CRH15132; CRH15132; BN1213_03150
PATRICifig|1773.206.peg.3024

Phylogenomic databases

eggNOGiENOG4105CWR Bacteria
COG0317 LUCA

Family and domain databases

CDDicd00077 HDc, 1 hit
cd05399 NT_Rel-Spo_like, 1 hit
cd01668 TGS_RSH, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR002912 ACT_dom
IPR012675 Beta-grasp_dom_sf
IPR003607 HD/PDEase_dom
IPR004811 RelA/Spo_fam
IPR007685 RelA_SpoT
IPR004095 TGS
IPR012676 TGS-like
IPR033655 TGS_RelA
PfamiView protein in Pfam
PF13291 ACT_4, 1 hit
PF04607 RelA_SpoT, 1 hit
PF02824 TGS, 1 hit
SMARTiView protein in SMART
SM00471 HDc, 1 hit
SM00954 RelA_SpoT, 1 hit
SUPFAMiSSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00691 spoT_relA, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS51831 HD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045GTV1_MYCTX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045GTV1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 13, 2019
This is version 58 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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