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Entry version 62 (17 Jun 2020)
Sequence version 1 (09 Jul 2014)
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Protein

Prephenate dehydratase

Gene

pheA

Organism
Mycobacterium tuberculosis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-phenylalanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phenylpyruvate from prephenate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydratase (pheA)
This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phenylpyruvate from prephenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei182Essential for prephenate dehydratase activityUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00121;UER00345

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prephenate dehydrataseUniRule annotation (EC:4.2.1.51UniRule annotation)
Short name:
PDTUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pheAUniRule annotationImported
Synonyms:pheA_1Imported
ORF Names:AYJ03_020270Imported, DSI38_21300Imported, E5M05_13780Imported, ERS007663_03265Imported, ERS007741_01823Imported, ERS013471_00450Imported, ERS023446_01443Imported, ERS024276_02031Imported, ERS027659_02374Imported, ERS094182_03371Imported, GJE03_20175Imported, SAMEA2683035_00042Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1773 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000256245 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000049989 Componenti: Unassembled WGS sequence
  • UP000048600 Componenti: Unassembled WGS sequence
  • UP000047893 Componenti: Unassembled WGS sequence
  • UP000039953 Componenti: Unassembled WGS sequence
  • UP000075723 Componenti: Chromosome
  • UP000182946 Componenti: Unassembled WGS sequence
  • UP000046213 Componenti: Unassembled WGS sequence
  • UP000298175 Componenti: Unassembled WGS sequence
  • UP000388593 Componenti: Chromosome
  • UP000040993 Componenti: Unassembled WGS sequence
  • UP000050164 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 189Prephenate dehydrataseInterPro annotationAdd BLAST187
Domaini203 – 280ACTInterPro annotationAdd BLAST78

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CQC Bacteria
COG0077 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002912 ACT_dom
IPR008242 Chor_mutase/pphenate_deHydtase
IPR001086 Preph_deHydtase
IPR018528 Preph_deHydtase_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01842 ACT, 1 hit
PF00800 PDT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001500 Chor_mut_pdt_Ppr, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51671 ACT, 1 hit
PS00858 PREPHENATE_DEHYDR_2, 1 hit
PS51171 PREPHENATE_DEHYDR_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A045GP75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRIAYLGPE GTFTEAALVR MVAAGLVPET GPDALQRMPV ESAPAALAAV
60 70 80 90 100
RDGGADYACV PIENSIDGSV LPTLDSLAIG VRLQVFAETT LDVTFSIVVK
110 120 130 140 150
PGRNAADVRT LAAFPVAAAQ VRQWLAAHLP AADLRPAYSN ADAARQVADG
160 170 180 190 200
LVDAAVTSPL AAARWGLAAL ADGVVDESNA RTRFVLVGRP GPPPARTGAD
210 220 230 240 250
RTSAVLRIDN QPGALVAALA EFGIRGIDLT RIESRPTRTE LGTYLFFVDC
260 270 280 290 300
VGHIDDEAVA EALKAVHRRC ADVRYLGSWP TGPAAGAQPP LVDEASRWLA
310 320
RLRAGKPEQT LVRPDDQGAQ A
Length:321
Mass (Da):33,633
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA50F13226F788EE5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CNCN01000483 Genomic DNA Translation: CKO78931.1
CNFT01000554 Genomic DNA Translation: CKR90980.1
CQGE01000023 Genomic DNA Translation: CNM85492.1
CQPV01000624 Genomic DNA Translation: CNV42975.1
CQTT01000007 Genomic DNA Translation: CNY11222.1
CHKL01000175 Genomic DNA Translation: COW20853.1
CVKR01000030 Genomic DNA Translation: CRF27900.1
CP045962 Genomic DNA Translation: QGK80894.1
CP046529 Genomic DNA Translation: QGV23377.1
QSXJ01001071 Genomic DNA Translation: REM61698.1
FPTZ01000001 Genomic DNA Translation: SGG99864.1
SRLI01000027 Genomic DNA Translation: TGE02045.1

NCBI Reference Sequences

More...
RefSeqi
WP_003420906.1, NZ_WJSJ01000015.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AMC48362; AMC48362; RN05_4086
CKO78931; CKO78931; ERS024276_02031
CKR35069; CKR35069; ERS027653_01144
CKR90980; CKR90980; ERS027659_02374
CKS07917; CKS07917; ERS027644_02549
CKS11300; CKS11300; ERS027652_02744
CKT47781; CKT47781; ERS027666_02872
CNM85492; CNM85492; ERS023446_01443
CNV42975; CNV42975; ERS007663_03265
CNY11222; CNY11222; ERS013471_00450
COW20853; COW20853; ERS007741_01823
CRH09866; CRH09866; BN1213_00397
CRH14761; CRH14761; BN1303_02817

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1773.211.peg.3379

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CNCN01000483 Genomic DNA Translation: CKO78931.1
CNFT01000554 Genomic DNA Translation: CKR90980.1
CQGE01000023 Genomic DNA Translation: CNM85492.1
CQPV01000624 Genomic DNA Translation: CNV42975.1
CQTT01000007 Genomic DNA Translation: CNY11222.1
CHKL01000175 Genomic DNA Translation: COW20853.1
CVKR01000030 Genomic DNA Translation: CRF27900.1
CP045962 Genomic DNA Translation: QGK80894.1
CP046529 Genomic DNA Translation: QGV23377.1
QSXJ01001071 Genomic DNA Translation: REM61698.1
FPTZ01000001 Genomic DNA Translation: SGG99864.1
SRLI01000027 Genomic DNA Translation: TGE02045.1
RefSeqiWP_003420906.1, NZ_WJSJ01000015.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAMC48362; AMC48362; RN05_4086
CKO78931; CKO78931; ERS024276_02031
CKR35069; CKR35069; ERS027653_01144
CKR90980; CKR90980; ERS027659_02374
CKS07917; CKS07917; ERS027644_02549
CKS11300; CKS11300; ERS027652_02744
CKT47781; CKT47781; ERS027666_02872
CNM85492; CNM85492; ERS023446_01443
CNV42975; CNV42975; ERS007663_03265
CNY11222; CNY11222; ERS013471_00450
COW20853; COW20853; ERS007741_01823
CRH09866; CRH09866; BN1213_00397
CRH14761; CRH14761; BN1303_02817
PATRICifig|1773.211.peg.3379

Phylogenomic databases

eggNOGiENOG4105CQC Bacteria
COG0077 LUCA

Enzyme and pathway databases

UniPathwayiUPA00121;UER00345

Family and domain databases

InterProiView protein in InterPro
IPR002912 ACT_dom
IPR008242 Chor_mutase/pphenate_deHydtase
IPR001086 Preph_deHydtase
IPR018528 Preph_deHydtase_CS
PfamiView protein in Pfam
PF01842 ACT, 1 hit
PF00800 PDT, 1 hit
PIRSFiPIRSF001500 Chor_mut_pdt_Ppr, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS00858 PREPHENATE_DEHYDR_2, 1 hit
PS51171 PREPHENATE_DEHYDR_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A045GP75_MYCTX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A045GP75
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: June 17, 2020
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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