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Protein

Thymidine kinase

Gene

tdk

Organism
Escherichia coli
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi182ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi87 – 90ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:A8C65_06995Imported, A9R57_00175Imported, ACU57_17605Imported, AM266_12505Imported, APT13_20510Imported, AUQ13_16185Imported, BET08_38460Imported, BHS87_06500Imported, BJJ90_10870Imported, BUE81_18965Imported, BZL31_06495Imported, C4J69_06930Imported, C5N07_14800Imported, C9E25_09550Imported, CA593_21685Imported, DNQ41_10630Imported, EC3234A_230c00230Imported, EL75_2529Imported, EL79_2534Imported, EL80_2535Imported, ERS085365_01740Imported, ERS085416_00023Imported, ERS139211_03179Imported, ERS150873_03089Imported, NCTC11022_01022Imported, NCTC13148_00437Imported, NCTC13462_00804Imported, NCTC9010_03083Imported, NCTC9037_03126Imported, NCTC9060_00528Imported, NCTC9110_02722Imported, NCTC9117_03682Imported, NCTC9706_00225Imported, NCTC9962_06128Imported, RK56_003885Imported, SAMEA3472067_03015Imported, SAMEA3472080_01191Imported, SAMEA3484427_01680Imported, SAMEA3484429_01545Imported, SAMEA3752559_01273Imported, SAMEA3753106_02893Imported, SAMEA3753300_01537Imported, SAMEA3753391_01924Imported, SAMEA3753397_00765Imported, SK85_01372Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A037Y488-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTVVYTAEI DDRFGAGKVS
60 70 80 90 100
SRIGLSSPAK LFNQNSSLFD EIRAEHEQQA IHCVLVDECQ FLTRQQVYEL
110 120 130 140 150
SEVVDQLDIP VLCYGLRTDF RGELFIGSQY LLAWSDKLVE LKTICFCGRK
160 170 180 190 200
ASMVLRLDQA GRPYNEGEQV VIGGNERYVS VCRKHYKEAL QVDSLTAIQE

RHRHD
Length:205
Mass (Da):23,457
Last modified:July 9, 2014 - v1
Checksum:i533166D9EAD20E16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017631 Genomic DNA Translation: APT02479.1
CP021175 Genomic DNA Translation: ARR35502.1
CP029973 Genomic DNA Translation: AWV10716.1
CYAQ01000012 Genomic DNA Translation: CTS45052.1
CYCX01000001 Genomic DNA Translation: CTU79587.1
CYDH01000033 Genomic DNA Translation: CTW42117.1
CYFX01000021 Genomic DNA Translation: CTZ58921.1
JPKH01000037 Genomic DNA Translation: KGM69110.1
JPKL01000088 Genomic DNA Translation: KGM78640.1
JPMZ01000040 Genomic DNA Translation: KGM81550.1
LEUM01000009 Genomic DNA Translation: KLX99583.1
LDYI01000118 Genomic DNA Translation: KPO09370.1
LIVE01000018 Genomic DNA Translation: KQJ15284.1
LOOZ01000023 Genomic DNA Translation: KXR89365.1
LCVH01000230 Genomic DNA Translation: OAC28457.1
LZEH01000112 Genomic DNA Translation: OEI65362.1
MSEK01000134 Genomic DNA Translation: OLR85735.1
MCNL01001098 Genomic DNA Translation: ONK53052.1
NAFT01000024 Genomic DNA Translation: ORT08011.1
MUAB01000009 Genomic DNA Translation: OUK53234.1
LYBG01000474 Genomic DNA Translation: OWD72843.1
JWSO02000008 Genomic DNA Translation: PNP05540.1
PSSV01000005 Genomic DNA Translation: PPI95632.1
PUJR01000014 Genomic DNA Translation: PQP09357.1
PYRW01000012 Genomic DNA Translation: PSZ84709.1
QOWX01000032 Genomic DNA Translation: RCR54064.1
UARY01000009 Genomic DNA Translation: SPW71955.1
UCUN01000009 Genomic DNA Translation: SQK30297.1
UCZF01000006 Genomic DNA Translation: SQP86663.1
UDAQ01000021 Genomic DNA Translation: SQR68513.1
UDCU01000005 Genomic DNA Translation: SQU63081.1
UDDW01000002 Genomic DNA Translation: SQX12504.1
UDGC01000008 Genomic DNA Translation: SQY36686.1
UDGL01000007 Genomic DNA Translation: SQZ10176.1
UFYM01000003 Genomic DNA Translation: STD57994.1
UGCG01000003 Genomic DNA Translation: STI32702.1
UGCZ01000001 Genomic DNA Translation: STJ39640.1
UGDF01000003 Genomic DNA Translation: STJ66075.1
UGDG01000002 Genomic DNA Translation: STJ68665.1
UGDC01000003 Genomic DNA Translation: STJ81131.1
UGET01000004 Genomic DNA Translation: STL64458.1
UGED01000017 Genomic DNA Translation: STM14723.1
UGGJ01000004 Genomic DNA Translation: STN83288.1
UINI01000005 Genomic DNA Translation: SVF14993.1
UINP01000005 Genomic DNA Translation: SVF22861.1
RefSeqiWP_000068077.1, NZ_UILI01000025.1

Genome annotation databases

EnsemblBacteriaiCTS45052; CTS45052; ERS085365_01740
CTU79587; CTU79587; ERS085416_00023
CTW42117; CTW42117; ERS139211_03179
CTZ58921; CTZ58921; ERS150873_03089
KGM69110; KGM69110; EL75_2529
KGM78640; KGM78640; EL80_2535
KGM81550; KGM81550; EL79_2534
KIG79683; KIG79683; PU38_17130
KLX99583; KLX99583; SK85_01372
KPO09370; KPO09370; ACU57_17605
KQJ15284; KQJ15284; AM266_12505
KXQ40387; KXQ40387; AUQ01_08825
OAC28457; OAC28457; EC3234A_230c00230
OCO53015; OCO53015; AN669_0215565
ODH30841; ODH30841; A6803_09195
OEI65362; OEI65362; A9R57_00175
PATRICifig|562.10493.peg.1328

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017631 Genomic DNA Translation: APT02479.1
CP021175 Genomic DNA Translation: ARR35502.1
CP029973 Genomic DNA Translation: AWV10716.1
CYAQ01000012 Genomic DNA Translation: CTS45052.1
CYCX01000001 Genomic DNA Translation: CTU79587.1
CYDH01000033 Genomic DNA Translation: CTW42117.1
CYFX01000021 Genomic DNA Translation: CTZ58921.1
JPKH01000037 Genomic DNA Translation: KGM69110.1
JPKL01000088 Genomic DNA Translation: KGM78640.1
JPMZ01000040 Genomic DNA Translation: KGM81550.1
LEUM01000009 Genomic DNA Translation: KLX99583.1
LDYI01000118 Genomic DNA Translation: KPO09370.1
LIVE01000018 Genomic DNA Translation: KQJ15284.1
LOOZ01000023 Genomic DNA Translation: KXR89365.1
LCVH01000230 Genomic DNA Translation: OAC28457.1
LZEH01000112 Genomic DNA Translation: OEI65362.1
MSEK01000134 Genomic DNA Translation: OLR85735.1
MCNL01001098 Genomic DNA Translation: ONK53052.1
NAFT01000024 Genomic DNA Translation: ORT08011.1
MUAB01000009 Genomic DNA Translation: OUK53234.1
LYBG01000474 Genomic DNA Translation: OWD72843.1
JWSO02000008 Genomic DNA Translation: PNP05540.1
PSSV01000005 Genomic DNA Translation: PPI95632.1
PUJR01000014 Genomic DNA Translation: PQP09357.1
PYRW01000012 Genomic DNA Translation: PSZ84709.1
QOWX01000032 Genomic DNA Translation: RCR54064.1
UARY01000009 Genomic DNA Translation: SPW71955.1
UCUN01000009 Genomic DNA Translation: SQK30297.1
UCZF01000006 Genomic DNA Translation: SQP86663.1
UDAQ01000021 Genomic DNA Translation: SQR68513.1
UDCU01000005 Genomic DNA Translation: SQU63081.1
UDDW01000002 Genomic DNA Translation: SQX12504.1
UDGC01000008 Genomic DNA Translation: SQY36686.1
UDGL01000007 Genomic DNA Translation: SQZ10176.1
UFYM01000003 Genomic DNA Translation: STD57994.1
UGCG01000003 Genomic DNA Translation: STI32702.1
UGCZ01000001 Genomic DNA Translation: STJ39640.1
UGDF01000003 Genomic DNA Translation: STJ66075.1
UGDG01000002 Genomic DNA Translation: STJ68665.1
UGDC01000003 Genomic DNA Translation: STJ81131.1
UGET01000004 Genomic DNA Translation: STL64458.1
UGED01000017 Genomic DNA Translation: STM14723.1
UGGJ01000004 Genomic DNA Translation: STN83288.1
UINI01000005 Genomic DNA Translation: SVF14993.1
UINP01000005 Genomic DNA Translation: SVF22861.1
RefSeqiWP_000068077.1, NZ_UILI01000025.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCTS45052; CTS45052; ERS085365_01740
CTU79587; CTU79587; ERS085416_00023
CTW42117; CTW42117; ERS139211_03179
CTZ58921; CTZ58921; ERS150873_03089
KGM69110; KGM69110; EL75_2529
KGM78640; KGM78640; EL80_2535
KGM81550; KGM81550; EL79_2534
KIG79683; KIG79683; PU38_17130
KLX99583; KLX99583; SK85_01372
KPO09370; KPO09370; ACU57_17605
KQJ15284; KQJ15284; AM266_12505
KXQ40387; KXQ40387; AUQ01_08825
OAC28457; OAC28457; EC3234A_230c00230
OCO53015; OCO53015; AN669_0215565
ODH30841; ODH30841; A6803_09195
OEI65362; OEI65362; A9R57_00175
PATRICifig|562.10493.peg.1328

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A037Y488_ECOLX
AccessioniPrimary (citable) accession number: A0A037Y488
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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