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Protein

UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligase

Gene

mpl

Organism
Escherichia coli O111:NM str. K6722
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramate + L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: peptidoglycan recycling

This protein is involved in the pathway peptidoglycan recycling, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan recycling and in Cell wall biogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 116ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00544

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramate--L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptandioate ligaseUniRule annotation (EC:6.3.2.45UniRule annotation)
Alternative name(s):
Murein peptide ligaseUniRule annotation
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligaseUniRule annotation
Gene namesi
Name:mplUniRule annotation
ORF Names:BY96_06780Imported
OrganismiEscherichia coli O111:NM str. K6722Imported
Taxonomic identifieri1446533 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000024307 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A027U8R7
SMRiA0A027U8R7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 101Mur_ligaseInterPro annotationAdd BLAST100
Domaini108 – 291Mur_ligase_MInterPro annotationAdd BLAST184
Domaini312 – 361Mur_ligase_CInterPro annotationAdd BLAST50

Sequence similaritiesi

Belongs to the MurCDEF family. Mpl subfamily.UniRule annotation

Family and domain databases

Gene3Di3.40.1190.10, 1 hit
3.90.190.20, 1 hit
HAMAPiMF_02020 Mpl, 1 hit
InterProiView protein in InterPro
IPR005757 Mpl
IPR036565 Mur-like_cat_sf
IPR004101 Mur_ligase_C
IPR036615 Mur_ligase_C_dom_sf
IPR013221 Mur_ligase_cen
IPR000713 Mur_ligase_N
PfamiView protein in Pfam
PF01225 Mur_ligase, 1 hit
PF02875 Mur_ligase_C, 1 hit
PF08245 Mur_ligase_M, 1 hit
SUPFAMiSSF53244 SSF53244, 1 hit
SSF53623 SSF53623, 1 hit
TIGRFAMsiTIGR01081 mpl, 1 hit

Sequencei

Sequence statusi: Complete.

A0A027U8R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIHILGICG TFMGGLAMLA RQLGHEVTGS DANVYPPMST LLEKQGIELI
60 70 80 90 100
QGYDASQLDP QPDLVIIGNA MTRGNPCVEA VLEKNIPYMS GPQWLHDFVL
110 120 130 140 150
RDRWVLAVAG THGKTTTAGM ATWILEQCGY KPGFVIGGVP GNFEVSARLG
160 170 180 190 200
ESDFFVIEAD EYDCAFFDKR SKFVHYCPRT LILNNLEFDH ADIFDDLKAI
210 220 230 240 250
QKQFHHLVRI VPGQGRIIWP ENDINLKQTM AMGCWSEQEL VGEQGHWQAK
260 270 280 290 300
KLTTDASEWE VLLDGEKVGE VKWSLVGEHN MHNGLMAIAA ARHVGVAPAD
310 320 330 340 350
AANALGSFIN ARRRLELRGE ANGVTVYDDF AHHPTAILAT LAALRGKVGG
360 370 380 390 400
TARIIAVLEP RSNTMKMGIC KDDLAPSLGR ADEVFLLQPA HIPWQVAEVA
410 420 430 440 450
EACVQPAHWS GDVDTLADMV VKTAQPGDHI LVMSNGGFGG IHQKLLDGLA

KKAEAAQ
Length:457
Mass (Da):49,879
Last modified:July 9, 2014 - v1
Checksum:i08C6FF7A3E89A0EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JHHU01000002 Genomic DNA Translation: EZD33955.1
RefSeqiWP_001219792.1, NZ_JHHU01000002.1

Genome annotation databases

EnsemblBacteriaiEZD33955; EZD33955; BY96_06780

Similar proteinsi

Entry informationi

Entry nameiA0A027U8R7_ECOLX
AccessioniPrimary (citable) accession number: A0A027U8R7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 25, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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