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Protein

RNA 2',3'-cyclic phosphodiesterase

Gene

thpR

Organism
Escherichia coli O111:NM str. K6722
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Proton donorUniRule annotation1
Active sitei125Proton acceptorUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotation, LigaseImported

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 2',3'-cyclic phosphodiesteraseUniRule annotation (EC:3.1.4.-UniRule annotation)
Short name:
RNA 2',3'-CPDaseUniRule annotation
Gene namesi
Name:thpRUniRule annotation
ORF Names:BY96_04965Imported
OrganismiEscherichia coli O111:NM str. K6722Imported
Taxonomic identifieri1446533 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000024307 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliA0A027U356
SMRiA0A027U356
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 89LigT_PEaseInterPro annotationAdd BLAST79
Domaini92 – 164LigT_PEaseInterPro annotationAdd BLAST73

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 46HXTX 1UniRule annotation4
Motifi125 – 128HXTX 2UniRule annotation4

Sequence similaritiesi

Belongs to the 2H phosphoesterase superfamily. ThpR family.UniRule annotation

Phylogenomic databases

OMAiGVVWLGC

Family and domain databases

HAMAPiMF_01940 RNA_CPDase, 1 hit
InterProiView protein in InterPro
IPR009097 cNuc_Pdiesterase
IPR014051 Phosphoesterase_HXTX
IPR004175 RNA_CPDase
PANTHERiPTHR35561 PTHR35561, 1 hit
PfamiView protein in Pfam
PF02834 LigT_PEase, 2 hits
SUPFAMiSSF55144 SSF55144, 1 hit
TIGRFAMsiTIGR02258 2_5_ligase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A027U356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEPQRLFFA IDLPAEIREQ IIHWRATHFP PEAGRPVAAD NLHLTLAFLG
60 70 80 90 100
EVSAEKEKAL SLLAGRIRQP GFTLTLDDAG QWLRSRVVWL GMRQPPRGLI
110 120 130 140 150
QLANMLRSQA ARSGCFQSNR PFHPHITLLR DASEAVTIPP PGFNWSYAVT
160 170
EFTLYASSFA RGRTRYTPLK RWALTQ
Length:176
Mass (Da):19,934
Last modified:July 9, 2014 - v1
Checksum:i9DAA9FB3CE4F777E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JHHU01000018 Genomic DNA Translation: EZD31677.1
RefSeqiWP_001294700.1, NZ_JHHU01000018.1

Genome annotation databases

EnsemblBacteriaiEZD31677; EZD31677; BY96_04965

Similar proteinsi

Entry informationi

Entry nameiA0A027U356_ECOLX
AccessioniPrimary (citable) accession number: A0A027U356
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: March 28, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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