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UniProtKB - A0A024SMV2 (XDH_HYPJR)
Protein
D-xylose 1-dehydrogenase (NADP(+))
Gene
xyd1
Organism
Hypocrea jecorina (strain ATCC 56765 / BCRC 32924 / NRRL 11460 / Rut C-30) (Trichoderma reesei)
Status
Functioni
NADP-dependent D-xylose dehydrogenase catalyzing the oxydation of D-xylose into D-xylonolactone. Displays also some, albeit lower activity with D-glucose, D-galactose and L-arabinose as substrate. Probably not involved in D-xylose degradation, as it has been shown that H.jecorina assimilates D-xylose via D-xylose reductase and xylitol dehydrogenase, and it is unable to grow on D-xylonic acid as sole carbon source. May play a role in the regeneration of NADP+ in the presence of D-xylose.
1 PublicationCatalytic activityi
- EC:1.1.1.1791 Publication
Kineticsi
- KM=250 µM for NADP+1 Publication
- KM=43 mM for D-xylose1 Publication
- KM=24 mM for D-glucose1 Publication
- KM=60 mM for L-arabinose1 Publication
- KM=100 mM for D-galactose1 Publication
- KM=145 mM for D-ribose1 Publication
- KM=390 mM for D-arabinose1 Publication
- Vmax=510 nmol/sec/mg enzyme toward NADP+1 Publication
- Vmax=500 nmol/sec/mg enzyme toward D-xylose1 Publication
- Vmax=130 nmol/sec/mg enzyme toward D-glucose1 Publication
- Vmax=117 nmol/sec/mg enzyme toward L-arabinose1 Publication
- Vmax=205 nmol/sec/mg enzyme toward D-galactose1 Publication
- Vmax=141 nmol/sec/mg enzyme toward D-ribose1 Publication
- Vmax=100 nmol/sec/mg enzyme toward D-arabinose1 Publication
GO - Molecular functioni
- D-xylose 1-dehydrogenase (NADP+) activity Source: UniProtKB-EC
- nucleotide binding Source: InterPro
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 1.1.1.179, 6451 |
SABIO-RKi | A0A024SMV2 |
Names & Taxonomyi
Protein namesi | Recommended name: D-xylose 1-dehydrogenase (NADP(+))1 Publication (EC:1.1.1.1791 Publication)Short name: XDH Alternative name(s): D-xylose-NADP dehydrogenase NADP(+)-dependent D-xylose dehydrogenase1 Publication |
Gene namesi | Name:xyd11 Publication ORF Names:M419DRAFT_31971 |
Organismi | Hypocrea jecorina (strain ATCC 56765 / BCRC 32924 / NRRL 11460 / Rut C-30) (Trichoderma reesei) |
Taxonomic identifieri | 1344414 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Hypocreaceae › Trichoderma › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000435965 | 1 – 391 | D-xylose 1-dehydrogenase (NADP(+))Add BLAST | 391 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Gfo/Idh/MocA family.Curated
Phylogenomic databases
HOGENOMi | CLU_023194_7_2_1 |
OrthoDBi | 943656at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000683, Gfo/Idh/MocA-like_OxRdtase_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01408, GFO_IDH_MocA, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024SMV2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASGNPYTLK WGIMATGGIA ETFCKDLLCN PAIRGADDVR HEIVAVASSS
60 70 80 90 100
SSKRAEEFLQ RIDGAFDAKT YGSYPELVAD PNVDIVYVAT PHSHHFQNTM
110 120 130 140 150
LALEAGKNVL CEKAFTVTAA QARKLVETAK AKKLFLMEAV WTRYFPLSIK
160 170 180 190 200
IRELIAAGEI GTVFRTIADL SINANSEQGQ ALKFADSHRM VNPDLAGGAT
210 220 230 240 250
LDLGVYPLTW VFQTLYHLQP EEDKEAPTVV ASSNKYTTGA DENTAIICSF
260 270 280 290 300
PRHNSIGIAS TTMRADTDPE KDTIPAVRIQ GSKGEIQVFF PTYRPLKYKV
310 320 330 340 350
VKTNGEAQTV DCPIPGDPAR KGSGHGMFWE ADECARCLRD GKLESATLPW
360 370 380 390
KESIVIMETM EEALRQGGVT YPELITTDVY DPKSPLNTGN Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF136590 mRNA Translation: ABO33081.1 KI911139 Genomic DNA Translation: ETS06670.1 |
Genome annotation databases
EnsemblFungii | ETS06670; ETS06670; M419DRAFT_31971 |
KEGGi | trr:M419DRAFT_31971 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF136590 mRNA Translation: ABO33081.1 KI911139 Genomic DNA Translation: ETS06670.1 |
3D structure databases
SMRi | A0A024SMV2 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | ETS06670; ETS06670; M419DRAFT_31971 |
KEGGi | trr:M419DRAFT_31971 |
Phylogenomic databases
HOGENOMi | CLU_023194_7_2_1 |
OrthoDBi | 943656at2759 |
Enzyme and pathway databases
BRENDAi | 1.1.1.179, 6451 |
SABIO-RKi | A0A024SMV2 |
Family and domain databases
InterProi | View protein in InterPro IPR000683, Gfo/Idh/MocA-like_OxRdtase_N IPR036291, NAD(P)-bd_dom_sf |
Pfami | View protein in Pfam PF01408, GFO_IDH_MocA, 1 hit |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | XDH_HYPJR | |
Accessioni | A0A024SMV2Primary (citable) accession number: A0A024SMV2 Secondary accession number(s): A8BT09 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 13, 2016 |
Last sequence update: | July 9, 2014 | |
Last modified: | June 2, 2021 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |