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Protein
Submitted name:

Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b

Gene

ARHGEF7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_bImported
Gene namesi
Name:ARHGEF7Imported
ORF Names:hCG_1811466Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000102606.17

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSG00000102606 Expressed in 224 organ(s), highest expression level in corpus callosum

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 65SH3InterPro annotationAdd BLAST60
Domaini93 – 273DHInterPro annotationAdd BLAST181
Domaini295 – 400PHInterPro annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili239 – 259Sequence analysisAdd BLAST21
Coiled coili274 – 294Sequence analysisAdd BLAST21
Coiled coili594 – 635Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035789 BetaPIX_SH3
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR032409 GEF_CC
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF16523 betaPIX_CC, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A024RDY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDNSNNQLV VRAKFNFQQT NEDELSFSKG DVIHVTRVEE GGWWEGTLNG
60 70 80 90 100
RTGWFPSNYV REVKASEKPV SPKSGTLKSP PKGFDTTAIN KSYYNVVLQN
110 120 130 140 150
ILETENEYSK ELQTVLSTYL RPLQTSEKLS SANISYLMGN LEEICSFQQM
160 170 180 190 200
LVQSLEECTK LPEAQQRVGG CFLNLMPQMK TLYLTYCANH PSAVNVLTEH
210 220 230 240 250
SEELGEFMET KGASSPGILV LTTGLSKPFM RLDKYPTLLK ELERHMEDYH
260 270 280 290 300
TDRQDIQKSM AAFKNLSAQC QEVRKRKELE LQILTEAIRN WEGDDIKTLG
310 320 330 340 350
NVTYMSQVLI QCAGSEEKNE RYLLLFPNVL LMLSASPRMS GFIYQGKLPT
360 370 380 390 400
TGMTITKLED SENHRNAFEI SGSMIERILV SCNNQQDLQE WVEHLQKQTK
410 420 430 440 450
VTSVGNPTIK PHSVPSHTLP SHPVTPSSKH ADSKPAPLTP AYHTLPHPSH
460 470 480 490 500
HGTPHTTINW GPLEPPKTPK PWSLSCLRPA PPLRPSAALC YKEDLSKSPK
510 520 530 540 550
TMKKLLPKRK PERKPSDEEF ASRKSTAALE EDAQILKVIE AYCTSAKTRQ
560 570 580 590 600
TLNSSSRKES APQVLLPEEE KIIVEETKSN GQTVIEEKSL VDTVYALKDE
610 620 630 640
VQELRQDNKK MKKSLEEEQR ARKDLEKLVR KVLKNMNDPA WDETNL
Length:646
Mass (Da):73,140
Last modified:July 9, 2014 - v1
Checksum:iB5B5A83F0EBC28D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471085 Genomic DNA Translation: EAX09144.1
CH471085 Genomic DNA Translation: EAX09149.1
RefSeqiNP_001106985.1, NM_001113513.1
NP_001307780.1, NM_001320851.1
NP_003890.1, NM_003899.3
XP_016876313.1, XM_017020824.1
XP_016876314.1, XM_017020825.1
UniGeneiHs.508738

Genome annotation databases

GeneIDi8874

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471085 Genomic DNA Translation: EAX09144.1
CH471085 Genomic DNA Translation: EAX09149.1
RefSeqiNP_001106985.1, NM_001113513.1
NP_001307780.1, NM_001320851.1
NP_003890.1, NM_003899.3
XP_016876313.1, XM_017020824.1
XP_016876314.1, XM_017020825.1
UniGeneiHs.508738

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8874

Organism-specific databases

CTDi8874
EuPathDBiHostDB:ENSG00000102606.17

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA

Miscellaneous databases

ChiTaRSiARHGEF7 human
GenomeRNAii8874

Gene expression databases

BgeeiENSG00000102606 Expressed in 224 organ(s), highest expression level in corpus callosum

Family and domain databases

CDDicd00160 RhoGEF, 1 hit
cd12061 SH3_betaPIX, 1 hit
Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035789 BetaPIX_SH3
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR032409 GEF_CC
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF16523 betaPIX_CC, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF07653 SH3_2, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024RDY9_HUMAN
AccessioniPrimary (citable) accession number: A0A024RDY9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 10, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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