UniProtKB - A0A024RDX3 (A0A024RDX3_HUMAN)
Protein
P-type Cu(+) transporter
Gene
ATP7B
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:7.2.2.8ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 69 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 72 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 154 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 157 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 268 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 271 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 370 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 373 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 499 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 502 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 575 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 578 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- copper ion binding Source: InterPro
- copper transmembrane transporter activity, phosphorylative mechanism Source: Ensembl
GO - Biological processi
- cellular copper ion homeostasis Source: Ensembl
- cellular zinc ion homeostasis Source: Ensembl
- lactation Source: Ensembl
- protein maturation by copper ion transfer Source: Ensembl
Keywordsi
Molecular function | TranslocaseARBA annotation |
Biological process | Copper transportARBA annotation, Ion transport, Transport |
Ligand | ATP-bindingUniRule annotationARBA annotation, Copper, Metal-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ATP7BImported ORF Names:hCG_27492Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000123191.14 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane UniRule annotation
Golgi apparatus
- Golgi apparatus Source: HPA
- trans-Golgi network Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-UniRule
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 654 – 673 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 693 – 715 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 727 – 753 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 759 – 780 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 923 – 950 | HelicalUniRule annotationAdd BLAST | 28 | |
Transmembranei | 970 – 990 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1325 – 1347 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000123191, Expressed in testis and 157 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 125 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 144 – 210 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 258 – 327 | HMAInterPro annotationAdd BLAST | 70 | |
Domaini | 360 – 426 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 489 – 555 | HMAInterPro annotationAdd BLAST | 67 | |
Domaini | 565 – 631 | HMAInterPro annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 230 – 249 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 322 – 355 | DisorderedSequence analysisAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 335 – 355 | PolarSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation
Keywords - Domaini
RepeatARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OMAi | GMHCMIS |
OrthoDBi | 649559at2759 |
Family and domain databases
CDDi | cd00371, HMA, 6 hits |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR017969, Heavy-metal-associated_CS IPR006122, HMA_Cu_ion-bd IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00403, HMA, 6 hits |
SUPFAMi | SSF55008, SSF55008, 6 hits SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 2 hits TIGR00003, TIGR00003, 6 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit PS01047, HMA_1, 6 hits PS50846, HMA_2, 6 hits |
i Sequence
Sequence statusi: Complete.
A0A024RDX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEQERQITA REGASRKILS KLSLPTRAWE PAMKKSFAFD NVGYEGGLDG
60 70 80 90 100
LGPSSQVATS TVRILGMTCQ SCVKSIEDRI SNLKGIISMK VSLEQGSATV
110 120 130 140 150
KYVPSVVCLQ QVCHQIGDMG FEASIAEGKA ASWPSRSLPA QEAVVKLRVE
160 170 180 190 200
GMTCQSCVSS IEGKVRKLQG VVRVKVSLSN QEAVITYQPY LIQPEDLRDH
210 220 230 240 250
VNDMGFEAAI KSKVAPLSLG PIDIERLQST NPKRPLSSAN QNFNNSETLG
260 270 280 290 300
HQGSHVVTLQ LRIDGMHCKS CVLNIEENIG QLLGVQSIQV SLENKTAQVK
310 320 330 340 350
YDPSCTSPVA LQRAIEALPP GNFKVSLPDG AEGSGTDHRS SSSHSPGSPP
360 370 380 390 400
RNQVQGTCST TLIAIAGMTC ASCVHSIEGM ISQLEGVQQI SVSLAEGTAT
410 420 430 440 450
VLYNPSVISP EELRAAIEDM GFEASVVSES CSTNPLGNHS AGNSMVQTTD
460 470 480 490 500
GTPTSVQEVA PHTGRLPANH APDILAKSPQ STRAVAPQKC FLQIKGMTCA
510 520 530 540 550
SCVSNIERNL QKEAGVLSVL VALMAGKAEI KYDPEVIQPL EIAQFIQDLG
560 570 580 590 600
FEAAVMEDYA GSDGNIELTI TGMTCASCVH NIESKLTRTN GITYASVALA
610 620 630 640 650
TSKALVKFDP EIIGPRDIIK IIEEIGFHAS LAQRNPNAHH LDHKMEIKQW
660 670 680 690 700
KKSFLCSLVF GIPVMALMIY MLIPSNEPHQ SMVLDHNIIP GLSILNLIFF
710 720 730 740 750
ILCTFVQLLG GWYFYVQAYK SLRHRSANMD VLIVLATSIA YVYSLVILVV
760 770 780 790 800
AVAEKAERSP VTFFDTPPML FVFIALGRWL EHLAKSKTSE ALAKLMSLQA
810 820 830 840 850
TEATVVTLGE DNLIIREEQV PMELVQRGDI VKVVPGGKFP VDGKVLEGNT
860 870 880 890 900
MADESLITGE AMPVTKKPGS TVIAGSINAH GSVLIKATHV GNDTTLAQIV
910 920 930 940 950
KLVEEAQMSK APIQQLADRF SGYFVPFIII MSTLTLVVWI VIGFIDFGVV
960 970 980 990 1000
QRYFPNPNKH ISQTEVIIRF AFQTSITVLC IACPCSLGLA TPTAVMVGTG
1010 1020 1030 1040 1050
VAAQNGILIK GGKPLEMAHK IKTVMFDKTG TITHGVPRVM RVLLLGDVAT
1060 1070 1080 1090 1100
LPLRKVLAVV GTAEASSEHP LGVAVTKYCK EELGTETLGY CTDFQAVPGC
1110 1120 1130 1140 1150
GIGCKVSNVE GILAHSERPL SAPASHLNEA GSLPAEKDAV PQTFSVLIGN
1160 1170 1180 1190 1200
REWLRRNGLT ISSDVSDAMT DHEMKGQTAI LVAIDGVLCG MIAIADAVKQ
1210 1220 1230 1240 1250
EAALAVHTLQ SMGVDVVLIT GDNRKTARAI ATQVGINKVF AEVLPSHKVA
1260 1270 1280 1290 1300
KVQELQNKGK KVAMVGDGVN DSPALAQADM GVAIGTGTDV AIEAADVVLI
1310 1320 1330 1340 1350
RNDLLDVVAS IHLSKRTVRR IRINLVLALI YNLVGIPIAA GVFMPIGIVL
1360 1370 1380 1390 1400
QPWMGSAAMA ASSVSVVLSS LQLKCYKKPD LERYEAQAHG HMKPLTASQV
1410 1420 1430 1440 1450
SVHIGMDDRW RDSPRATPWD QVSYVSQVSL SSLTSDKPSR HSAAADDDGD
1460
KWSLLLNGRD EEQYI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471075 Genomic DNA Translation: EAX08894.1 CH471075 Genomic DNA Translation: EAX08896.1 |
RefSeqi | NP_000044.2, NM_000053.3 XP_005266487.1, XM_005266430.4 |
Genome annotation databases
GeneIDi | 540 |
KEGGi | hsa:540 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471075 Genomic DNA Translation: EAX08894.1 CH471075 Genomic DNA Translation: EAX08896.1 |
RefSeqi | NP_000044.2, NM_000053.3 XP_005266487.1, XM_005266430.4 |
3D structure databases
SMRi | A0A024RDX3 |
ModBasei | Search... |
Proteomic databases
MaxQBi | A0A024RDX3 |
Protocols and materials databases
Antibodypediai | 2396, 497 antibodies |
Genome annotation databases
GeneIDi | 540 |
KEGGi | hsa:540 |
Organism-specific databases
CTDi | 540 |
EuPathDBi | HostDB:ENSG00000123191.14 |
Phylogenomic databases
OMAi | GMHCMIS |
OrthoDBi | 649559at2759 |
Miscellaneous databases
BioGRID-ORCSi | 540, 2 hits in 841 CRISPR screens |
ChiTaRSi | ATP7B, human |
GenomeRNAii | 540 |
Gene expression databases
Bgeei | ENSG00000123191, Expressed in testis and 157 other tissues |
Family and domain databases
CDDi | cd00371, HMA, 6 hits |
Gene3Di | 3.40.1110.10, 1 hit |
InterProi | View protein in InterPro IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR017969, Heavy-metal-associated_CS IPR006122, HMA_Cu_ion-bd IPR006121, HMA_dom IPR036163, HMA_dom_sf IPR027256, P-typ_ATPase_IB IPR001757, P_typ_ATPase |
Pfami | View protein in Pfam PF00403, HMA, 6 hits |
SUPFAMi | SSF55008, SSF55008, 6 hits SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01525, ATPase-IB_hvy, 1 hit TIGR01494, ATPase_P-type, 2 hits TIGR00003, TIGR00003, 6 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit PS01047, HMA_1, 6 hits PS50846, HMA_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RDX3_HUMAN | |
Accessioni | A0A024RDX3Primary (citable) accession number: A0A024RDX3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 54 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |