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Entry version 37 (10 Feb 2021)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Fibronectin type III domain containing 3A, isoform CRA_b

Gene

FNDC3A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Fibronectin type III domain containing 3A, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNDC3AImported
ORF Names:hCG_1811703Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000102531.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1118 – 1141HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102531, Expressed in chorionic villus and 247 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A024RDV5, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A0A024RDV5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 313Fibronectin type-IIIInterPro annotationAdd BLAST102
Domaini317 – 409Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini413 – 506Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini510 – 604Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini608 – 701Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini705 – 795Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini805 – 894Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini895 – 989Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini990 – 1095Fibronectin type-IIIInterPro annotationAdd BLAST106

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 197DisorderedSequence analysisAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi112 – 142PolyampholyteSequence analysisAdd BLAST31

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
633003at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024RDV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGPAQVPMM SPNGSVPPIY VPPGYAPQVI EDNGVRRVVV VPQAPEFHPG
60 70 80 90 100
SHTVLHRSPH PPLPGFIPVP TMMPPPPRHM YSPVTGAGDM TTQYMPQYQS
110 120 130 140 150
SQVYGDVDAH STHGRSNFRD ERSSKTYERL QKKLKDRQGT QKDKMSSPPS
160 170 180 190 200
SPQKCPSPIN EHNGLIKGQI AGGINTGSAK IKSGKGKGGT QVDTEIEEKD
210 220 230 240 250
EETKAFEALL SNIVKPVASD IQARTVVLTW SPPSSLINGE TDESSVPELY
260 270 280 290 300
GYEVLISSTG KDGKYKSVYV GEETNITLND LKPAMDYHAK VQAEYNSIKG
310 320 330 340 350
TPSEAEIFTT LSCEPDIPNP PRIANRTKNS LTLQWKAPSD NGSKIQNFVL
360 370 380 390 400
EWDEGKGNGE FCQCYMGSQK QFKITKLSPA MGCKFRLSAR NDYGTSGFSE
410 420 430 440 450
EVLYYTSGCA PSMPASPVLT KAGITWLSLQ WSKPSGTPSD EGISYILEME
460 470 480 490 500
EETSGYGFKP KYDGEDLAYT VKNLRRSTKY KFKVIAYNSE GKSNPSEVVE
510 520 530 540 550
FTTCPDKPGI PVKPSVKGKI HSHSFKITWD PPKDNGGATI NKYVVEMAEG
560 570 580 590 600
SNGNKWEMIY SGATREHLCD RLNPGCFYRL RVYCISDGGQ SAVSESLLVQ
610 620 630 640 650
TPAVPPGPCL PPRLQGRPKA KEIQLRWGPP LVDGGSPISC YSVEMSPIEK
660 670 680 690 700
DEPREVYQGS EVECTVSSLL PGKTYSFRLR AANKMGFGPF SEKCDITTAP
710 720 730 740 750
GPPDQCKPPQ VTCRSATCAQ VNWEVPLSNG TDVTEYRLEW GGVEGSMQIC
760 770 780 790 800
YCGPGLSYEI KGLSPATTYY CRVQALSVVG AGPFSEVVAC VTPPSVPGIV
810 820 830 840 850
TCLQEISDDE IENPHYSPST CLAISWEKPC DHGSEILAYS IDFGDKQSLT
860 870 880 890 900
VGKVTSYIIN NLQPDTTYRI RIQALNSLGA GPFSHMIKLK TKPLPPDPPR
910 920 930 940 950
LECVAFSHQN LKLKWGEGTP KTLSTDSIQY HLQMEDKNGR FVSLYRGPCH
960 970 980 990 1000
TYKVQRLNES TSYKFCIQAC NEAGEGPLSQ EYIFTTPKSV PAALKAPKIE
1010 1020 1030 1040 1050
KVNDHICEIT WECLQPMKGD PVIYSLQVML GKDSEFKQIY KGPDSSFRYS
1060 1070 1080 1090 1100
SLQLNCEYRF RVCAIRQCQD SLGHQDLVGP YSTTVLFISQ RTEPPASTNR
1110 1120 1130 1140
DTVESTRTRR ALSDEQCAAV ILVLFAFFSI LIAFIIQYFV IK
Length:1,142
Mass (Da):125,822
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2136F2F51012A73F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471075 Genomic DNA Translation: EAX08809.1

NCBI Reference Sequences

More...
RefSeqi
NP_055738.3, NM_014923.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22862

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471075 Genomic DNA Translation: EAX08809.1
RefSeqiNP_055738.3, NM_014923.4

3D structure databases

SMRiA0A024RDV5
ModBaseiSearch...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2293, 119 antibodies

Genome annotation databases

GeneIDi22862

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22862
VEuPathDBiHostDB:ENSG00000102531.16

Phylogenomic databases

OrthoDBi633003at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22862, 6 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FNDC3A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22862

Gene expression databases

BgeeiENSG00000102531, Expressed in chorionic villus and 247 other tissues
ExpressionAtlasiA0A024RDV5, baseline and differential

Family and domain databases

CDDicd00063, FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF00041, fn3, 7 hits
SMARTiView protein in SMART
SM00060, FN3, 9 hits
SUPFAMiSSF49265, SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024RDV5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024RDV5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: February 10, 2021
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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