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Protein
Submitted name:

Lymphocyte cytosolic protein 1 (L-plastin), isoform CRA_a

Gene

LCP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi22 – 33PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi62 – 73PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Lymphocyte cytosolic protein 1 (L-plastin), isoform CRA_aImported
Gene namesi
Name:LCP1Imported
ORF Names:hCG_2020552Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000136167.13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiA0A024RDT4

Expressioni

Gene expression databases

BgeeiENSG00000136167 Expressed in 176 organ(s), highest expression level in blood
ExpressionAtlasiA0A024RDT4 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA0A024RDT4
SMRiA0A024RDT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 44EF-handInterPro annotationAdd BLAST36
Domaini49 – 84EF-handInterPro annotationAdd BLAST36
Domaini120 – 236Calponin-homology (CH)InterPro annotationAdd BLAST117
Domaini264 – 375Calponin-homology (CH)InterPro annotationAdd BLAST112
Domaini394 – 503Calponin-homology (CH)InterPro annotationAdd BLAST110
Domaini515 – 624Calponin-homology (CH)InterPro annotationAdd BLAST110

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
KOiK17276
OMAiNAFQMTE
OrthoDBiEOG091G03YP
PhylomeDBiA0A024RDT4

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039953 LCP-1
PANTHERiPTHR19961 PTHR19961, 1 hit
PTHR19961:SF35 PTHR19961:SF35, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

A0A024RDT4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARGSVSDEE MMELREAFAK VDTDGNGYIS FNELNDLFKA ACLPLPGYRV
60 70 80 90 100
REITENLMAT GDLDQDGRIS FDEFIKIFHG LKSTDVAKTF RKAINKKEGI
110 120 130 140 150
CAIGGTSEQS SVGTQHSYSE EEKYAFVNWI NKALENDPDC RHVIPMNPNT
160 170 180 190 200
NDLFNAVGDG IVLCKMINLS VPDTIDERTI NKKKLTPFTI QENLNLALNS
210 220 230 240 250
ASAIGCHVVN IGAEDLKEGK PYLVLGLLWQ VIKIGLFADI ELSRNEALIA
260 270 280 290 300
LLREGESLED LMKLSPEELL LRWANYHLEN AGCNKIGNFS TDIKDSKAYY
310 320 330 340 350
HLLEQVAPKG DEEGVPAVVI DMSGLREKDD IQRAECMLQQ AERLGCRQFV
360 370 380 390 400
TATDVVRGNP KLNLAFIANL FNRYPALHKP ENQDIDWGAL EGETREERTF
410 420 430 440 450
RNWMNSLGVN PRVNHLYSDL SDALVIFQLY EKIKVPVDWN RVNKPPYPKL
460 470 480 490 500
GGNMKKLENC NYAVELGKNQ AKFSLVGIGG QDLNEGNRTL TLALIWQLMR
510 520 530 540 550
RYTLNILEEI GGGQKVNDDI IVNWVNETLR EAKKSSSISS FKDPKISTSL
560 570 580 590 600
PVLDLIDAIQ PGSINYDLLK TENLNDDEKL NNAKYAISMA RKIGARVYAL
610 620
PEDLVEVNPK MVMTVFACLM GKGMKRV
Length:627
Mass (Da):70,288
Last modified:July 9, 2014 - v1
Checksum:i668E4AA6A3FC7B58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471075 Genomic DNA Translation: EAX08758.1
RefSeqiNP_002289.2, NM_002298.4
XP_005266431.1, XM_005266374.1
UniGeneiHs.381099
Hs.658408

Genome annotation databases

GeneIDi3936
KEGGihsa:3936

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471075 Genomic DNA Translation: EAX08758.1
RefSeqiNP_002289.2, NM_002298.4
XP_005266431.1, XM_005266374.1
UniGeneiHs.381099
Hs.658408

3D structure databases

ProteinModelPortaliA0A024RDT4
SMRiA0A024RDT4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA0A024RDT4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3936
KEGGihsa:3936

Organism-specific databases

CTDi3936
EuPathDBiHostDB:ENSG00000136167.13

Phylogenomic databases

eggNOGiKOG0046 Eukaryota
COG5069 LUCA
KOiK17276
OMAiNAFQMTE
OrthoDBiEOG091G03YP
PhylomeDBiA0A024RDT4

Miscellaneous databases

ChiTaRSiLCP1 human
GenomeRNAii3936

Gene expression databases

BgeeiENSG00000136167 Expressed in 176 organ(s), highest expression level in blood
ExpressionAtlasiA0A024RDT4 baseline and differential

Family and domain databases

CDDicd00014 CH, 2 hits
cd00051 EFh, 1 hit
Gene3Di1.10.418.10, 4 hits
InterProiView protein in InterPro
IPR001589 Actinin_actin-bd_CS
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039959 Fimbrin/Plastin
IPR039953 LCP-1
PANTHERiPTHR19961 PTHR19961, 1 hit
PTHR19961:SF35 PTHR19961:SF35, 1 hit
PfamiView protein in Pfam
PF00307 CH, 4 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00033 CH, 4 hits
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019 ACTININ_1, 1 hit
PS00020 ACTININ_2, 2 hits
PS50021 CH, 4 hits
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA0A024RDT4_HUMAN
AccessioniPrimary (citable) accession number: A0A024RDT4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: November 7, 2018
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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