UniProtKB - A0A024RD91 (A0A024RD91_HUMAN)
Protein
Submitted name:
BCR downstream signaling 1, isoform CRA_a
Gene
BRDG1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- macrophage colony-stimulating factor receptor binding Source: Ensembl
- transmembrane receptor protein tyrosine kinase adaptor activity Source: Ensembl
GO - Biological processi
- cellular response to lipopolysaccharide Source: Ensembl
- negative regulation of macrophage chemotaxis Source: Ensembl
- negative regulation of macrophage colony-stimulating factor signaling pathway Source: Ensembl
- negative regulation of microglial cell migration Source: Ensembl
- negative regulation of phosphorylation Source: Ensembl
- negative regulation of ruffle assembly Source: Ensembl
- positive regulation of actin cytoskeleton reorganization Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of microglial cell activation Source: Ensembl
- positive regulation of microglial cell mediated cytotoxicity Source: Ensembl
- positive regulation of phagocytosis, engulfment Source: Ensembl
Names & Taxonomyi
Protein namesi | Submitted name: BCR downstream signaling 1, isoform CRA_aImported |
Gene namesi | Name:BRDG1Imported ORF Names:hCG_40344Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000035720.7 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000035720, Expressed in tonsil and 110 other tissues |
ExpressionAtlasi | A0A024RD91, baseline and differential |
Interactioni
GO - Molecular functioni
- macrophage colony-stimulating factor receptor binding Source: Ensembl
- transmembrane receptor protein tyrosine kinase adaptor activity Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 121 | PHInterPro annotationAdd BLAST | 97 | |
Domaini | 182 – 280 | SH2InterPro annotationAdd BLAST | 99 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 270 – 295 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 279 – 295 | PolyampholyteSequence analysisAdd BLAST | 17 |
Keywords - Domaini
SH2 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_043957_1_0_1 |
OMAi | NCANFTL |
OrthoDBi | 680358at2759 |
PhylomeDBi | A0A024RD91 |
Family and domain databases
CDDi | cd10403, SH2_STAP1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000980, SH2 IPR036860, SH2_dom_sf IPR039111, STAP1/STAP2 IPR035877, STAP1_SH2 |
PANTHERi | PTHR16186, PTHR16186, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00017, SH2, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RD91-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMAKKPPKPA PRRIFQERLK ITALPLYFEG FLLIKRSGYR EYEHYWTELR
60 70 80 90 100
GTTLFFYTDK KSIIYVDKLD IVDLTCLTEQ NSTEKNCAKF TLVLPKEEVQ
110 120 130 140 150
LKTENTESGE EWRGFILTVT ELSVPQNVSL LPGQVIKLHE VLEREKKRRI
160 170 180 190 200
ETEQSTSVEK EKEPTEDYVD VLNPMPACFY TVSRKEATEM LQKNPSLGNM
210 220 230 240 250
ILRPGSDSRN YSITIRQEID IPRIKHYKVM SVGQNYTIEL EKPVTLPNLF
260 270 280 290
SVIDYFVKET RGNLRPFICS TDENTGQEPS MEGRSEKLKK NPHIA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471057 Genomic DNA Translation: EAX05548.1 |
RefSeqi | NP_001304698.1, NM_001317769.1 NP_036240.1, NM_012108.3 |
Genome annotation databases
GeneIDi | 26228 |
KEGGi | hsa:26228 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471057 Genomic DNA Translation: EAX05548.1 |
RefSeqi | NP_001304698.1, NM_001317769.1 NP_036240.1, NM_012108.3 |
3D structure databases
SMRi | A0A024RD91 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 24136, 209 antibodies |
Genome annotation databases
GeneIDi | 26228 |
KEGGi | hsa:26228 |
Organism-specific databases
CTDi | 26228 |
EuPathDBi | HostDB:ENSG00000035720.7 |
Phylogenomic databases
HOGENOMi | CLU_043957_1_0_1 |
OMAi | NCANFTL |
OrthoDBi | 680358at2759 |
PhylomeDBi | A0A024RD91 |
Miscellaneous databases
BioGRID-ORCSi | 26228, 8 hits in 850 CRISPR screens |
ChiTaRSi | STAP1, human |
GenomeRNAii | 26228 |
Gene expression databases
Bgeei | ENSG00000035720, Expressed in tonsil and 110 other tissues |
ExpressionAtlasi | A0A024RD91, baseline and differential |
Family and domain databases
CDDi | cd10403, SH2_STAP1, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR000980, SH2 IPR036860, SH2_dom_sf IPR039111, STAP1/STAP2 IPR035877, STAP1_SH2 |
PANTHERi | PTHR16186, PTHR16186, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00017, SH2, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00252, SH2, 1 hit |
SUPFAMi | SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50001, SH2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RD91_HUMAN | |
Accessioni | A0A024RD91Primary (citable) accession number: A0A024RD91 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |