HSP90AB1

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
ATP hydrolysis activity Source: InterPro
CTP binding Source: Ensembl
dATP binding Source: Ensembl
GTP binding Source: Ensembl
protein folding chaperone Source: Ensembl
protein kinase binding Source: Ensembl
protein kinase regulator activity Source: Ensembl
sulfonylurea receptor binding Source: Ensembl
tau protein binding Source: Ensembl
transmembrane transporter binding Source: Ensembl
unfolded protein binding Source: InterPro
UTP binding Source: Ensembl

GO - Biological processⁱ

axon extension Source: Ensembl
cellular response to heat Source: Ensembl
cellular response to interleukin-4 Source: Ensembl
cellular response to organic cyclic compound Source: Ensembl
central nervous system neuron axonogenesis Source: Ensembl
establishment of cell polarity Source: Ensembl
negative regulation of complement-dependent cytotoxicity Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
negative regulation of proteasomal protein catabolic process Source: Ensembl
placenta development Source: Ensembl
positive regulation of cell size Source: Ensembl
positive regulation of cyclin-dependent protein kinase activity Source: Ensembl
positive regulation of peptidyl-serine phosphorylation Source: Ensembl
positive regulation of protein binding Source: Ensembl
positive regulation of protein import into nucleus Source: Ensembl
positive regulation of protein kinase B signaling Source: Ensembl
positive regulation of protein serine/threonine kinase activity Source: Ensembl
response to cocaine Source: Ensembl
response to salt stress Source: Ensembl
response to xenobiotic stimulus Source: Ensembl

Keywordsⁱ

Molecular function	ChaperoneARBA annotation
Biological process	Stress responseImported
Ligand	ATP-bindingARBA annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_aImported
Gene namesⁱ	Name:HSP90AB1Imported ORF Names:hCG_19001Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

VEuPathDBⁱ	HostDB:ENSG00000096384

VEuPathDBⁱ

HostDB:ENSG00000096384

PTM / Processingⁱ

Keywords - PTMⁱ

AcetylationARBA annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000096384, Expressed in hypothalamus and 252 other tissues

Bgeeⁱ

ENSG00000096384, Expressed in hypothalamus and 252 other tissues

Interactionⁱ

GO - Molecular functionⁱ

protein kinase binding Source: Ensembl
sulfonylurea receptor binding Source: Ensembl
tau protein binding Source: Ensembl
transmembrane transporter binding Source: Ensembl
unfolded protein binding Source: InterPro

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	A0A024RD80, 1 interactor

IntActⁱ

A0A024RD80, 1 interactor

Structureⁱ

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	35 – 189	HATPase_cInterPro annotationAdd BLAST		155

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	222 – 270	DisorderedSequence analysisAdd BLAST		49
Regionⁱ	696 – 724	DisorderedSequence analysisAdd BLAST		29

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	543 – 563	Sequence analysisAdd BLAST		21

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	241 – 270	Basic and acidic residuesSequence analysisAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the heat shock protein 90 family.ARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMⁱ	CLU_006684_1_3_1
OMAⁱ	TRMKAEQ
Database of Orthologous Groups More...OrthoDBⁱ	924636at2759

Family and domain databases

Gene3Dⁱ	1.20.120.790, 1 hit 3.30.565.10, 1 hit
HAMAPⁱ	MF_00505, HSP90, 1 hit
InterProⁱ	View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold
PANTHERⁱ	PTHR11528, PTHR11528, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit
PIRSFⁱ	PIRSF002583, Hsp90, 1 hit
PRINTSⁱ	PR00775, HEATSHOCK90
SMARTⁱ	View protein in SMART SM00387, HATPase_c, 1 hit
SUPFAMⁱ	SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS00298, HSP90, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A024RD80-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA 
        60         70         80         90        100
LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN 
       110        120        130        140        150
NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN 
       160        170        180        190        200
DDEQYAWESS AGGSFTVRAD HGEPIGRGTK VILHLKEDQT EYLEERRVKE 
       210        220        230        240        250
VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKDDEEKPKI 
       260        270        280        290        300
EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE 
       310        320        330        340        350
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK 
       360        370        380        390        400
NNIKLYVRRV FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI 
       410        420        430        440        450
LKVIRKNIVK KCLELFSELA EDKENYKKFY EAFSKNLKLG IHEDSTNRRR 
       460        470        480        490        500
LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES KEQVANSAFV 
       510        520        530        540        550
ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK 
       560        570        580        590        600
KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA 
       610        620        630        640        650
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA 
       660        670        680        690        700
VKDLVVLLFE TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP 
       710        720 
NAAVPDEIPP LEGDEDASRM EEVD

Length:724

Mass (Da):83,264

Last modified:July 9, 2014 - v1

Checksum:ⁱA93118C214D03810

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471081 Genomic DNA Translation: EAX04258.1 CH471081 Genomic DNA Translation: EAX04260.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001258898.1, NM_001271969.1 NP_001258899.1, NM_001271970.1 NP_031381.2, NM_007355.3

Genome annotation databases

GeneIDⁱ	3326
KEGGⁱ	hsa:3326
MANE-Selectⁱ	ENST00000371646.10; ENSP00000360709.5; NM_007355.4; NP_031381.2

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A024RD80	Heat shock protein HSP 90-beta	)	HUMAN		724	UniRef100_P08238
Heat shock protein 83		Heterotrigona itama		724
HS90B protein (Fragment)		Pteruthius melanotis		212
Heat shock protein HSP 90-beta-like		AILME		335
cDNA FLJ77842		HUMAN		362
+2

Protein	Similar proteins		Species	Score	Length	Source
A0A024RD80	Heat shock protein HSP 90-beta	)	HUMAN		724	UniRef90_P08238
Heat shock protein HSP 90-beta		MOUSE		724
Heat shock protein HSP 90-beta		RAT		724
Heat shock protein HSP 90-beta		PONAB		724
Heat shock protein 83		Heterotrigona itama		724
+256

Protein	Similar proteins		Species	Score	Length	Source
A0A024RD80	Heat shock protein HSP 90-beta	)	HUMAN		724	UniRef50_P08238
Heat shock protein HSP 90-beta		MOUSE		724
Heat shock protein HSP 90-beta		RAT		724
Heat shock protein HSP 90-beta		PONAB		724
Heat shock protein HSP 90-alpha 1		DANRE		725
+1100

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH471081 Genomic DNA Translation: EAX04258.1 CH471081 Genomic DNA Translation: EAX04260.1
RefSeqⁱ	NP_001258898.1, NM_001271969.1 NP_001258899.1, NM_001271970.1 NP_031381.2, NM_007355.3

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Protein-protein interaction databases

IntActⁱ	A0A024RD80, 1 interactor

IntActⁱ

A0A024RD80, 1 interactor

Protocols and materials databases

Antibodypediaⁱ	3929, 1728 antibodies from 47 providers
The DNASU plasmid repository More...DNASUⁱ	3326

Genome annotation databases

GeneIDⁱ	3326
KEGGⁱ	hsa:3326
MANE-Selectⁱ	ENST00000371646.10; ENSP00000360709.5; NM_007355.4; NP_031381.2

Organism-specific databases

CTDⁱ	3326
VEuPathDBⁱ	HostDB:ENSG00000096384

Phylogenomic databases

HOGENOMⁱ	CLU_006684_1_3_1
OMAⁱ	TRMKAEQ
OrthoDBⁱ	924636at2759

Miscellaneous databases

BioGRID-ORCSⁱ	3326, 110 hits in 1067 CRISPR screens
ChiTaRSⁱ	HSP90AB1, human
GenomeRNAiⁱ	3326

Gene expression databases

Bgeeⁱ	ENSG00000096384, Expressed in hypothalamus and 252 other tissues

Bgeeⁱ

ENSG00000096384, Expressed in hypothalamus and 252 other tissues

Family and domain databases

Gene3Dⁱ	1.20.120.790, 1 hit 3.30.565.10, 1 hit
HAMAPⁱ	MF_00505, HSP90, 1 hit
InterProⁱ	View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold
PANTHERⁱ	PTHR11528, PTHR11528, 1 hit
Pfamⁱ	View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit
PIRSFⁱ	PIRSF002583, Hsp90, 1 hit
PRINTSⁱ	PR00775, HEATSHOCK90
SMARTⁱ	View protein in SMART SM00387, HATPase_c, 1 hit
SUPFAMⁱ	SSF110942, SSF110942, 1 hit SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit
PROSITEⁱ	View protein in PROSITE PS00298, HSP90, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A024RD80_HUMAN
Accessionⁱ	A0A024RD80Primary (citable) accession number: A0A024RD80
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 9, 2014
	Last sequence update:	July 9, 2014
	Last modified:	January 19, 2022
	This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A024RD80 (A0A024RD80_HUMAN)

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Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Lysosome

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ