UniProtKB - A0A024RD80 (A0A024RD80_HUMAN)
Protein
Submitted name:
Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a
Gene
HSP90AB1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: Ensembl
- CTP binding Source: Ensembl
- dATP binding Source: Ensembl
- GTP binding Source: Ensembl
- ion channel binding Source: Ensembl
- protein folding chaperone Source: Ensembl
- protein kinase binding Source: Ensembl
- protein kinase regulator activity Source: Ensembl
- sulfonylurea receptor binding Source: Ensembl
- tau protein binding Source: Ensembl
- unfolded protein binding Source: InterPro
- UTP binding Source: Ensembl
GO - Biological processi
- axon extension Source: Ensembl
- cellular response to drug Source: Ensembl
- cellular response to heat Source: Ensembl
- cellular response to interleukin-4 Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- central nervous system neuron axonogenesis Source: Ensembl
- establishment of cell polarity Source: Ensembl
- negative regulation of complement-dependent cytotoxicity Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- negative regulation of proteasomal protein catabolic process Source: Ensembl
- placenta development Source: Ensembl
- positive regulation of cell size Source: Ensembl
- positive regulation of cyclin-dependent protein kinase activity Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of protein kinase B signaling Source: Ensembl
- positive regulation of protein serine/threonine kinase activity Source: Ensembl
- regulation of cellular protein localization Source: Ensembl
- response to cocaine Source: Ensembl
- response to salt stress Source: Ensembl
Keywordsi
Biological process | Stress responseImported |
Names & Taxonomyi
Protein namesi | Submitted name: Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_aImported |
Gene namesi | Name:HSP90AB1Imported ORF Names:hCG_19001Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Lysosome
- lysosomal membrane Source: Ensembl
Plasma Membrane
- apical plasma membrane Source: Ensembl
- basolateral plasma membrane Source: Ensembl
- brush border membrane Source: Ensembl
- sperm head plasma membrane Source: Ensembl
Other locations
- axonal growth cone Source: Ensembl
- cell surface Source: Ensembl
- dendritic growth cone Source: Ensembl
- HSP90-CDC37 chaperone complex Source: Ensembl
- inclusion body Source: Ensembl
- neuronal cell body Source: Ensembl
- ooplasm Source: Ensembl
- perinuclear region of cytoplasm Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000096384 Expressed in 240 organ(s), highest expression level in hypothalamus |
ExpressionAtlasi | A0A024RD80 baseline and differential |
Interactioni
GO - Molecular functioni
- ion channel binding Source: Ensembl
- protein kinase binding Source: Ensembl
- sulfonylurea receptor binding Source: Ensembl
- tau protein binding Source: Ensembl
- unfolded protein binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 189 | HATPase_cInterPro annotationAdd BLAST | 155 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 222 – 270 | DisorderedSequence analysisAdd BLAST | 49 | |
Regioni | 696 – 724 | DisorderedSequence analysisAdd BLAST | 29 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 543 – 563 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 241 – 270 | PolyampholyteSequence analysisAdd BLAST | 30 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0019 Eukaryota KOG0020 Eukaryota COG0326 LUCA |
KOi | K04079 |
OMAi | RTDHGEP |
OrthoDBi | 924636at2759 |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505 HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR019805 Heat_shock_protein_90_CS IPR037196 HSP90_C IPR001404 Hsp90_fam IPR020575 Hsp90_N IPR020568 Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528 PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518 HATPase_c, 1 hit PF00183 HSP90, 1 hit |
PIRSFi | PIRSF002583 Hsp90, 1 hit |
PRINTSi | PR00775 HEATSHOCK90 |
SMARTi | View protein in SMART SM00387 HATPase_c, 1 hit |
SUPFAMi | SSF110942 SSF110942, 1 hit SSF54211 SSF54211, 1 hit SSF55874 SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298 HSP90, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RD80-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEEVHHGEE EVETFAFQAE IAQLMSLIIN TFYSNKEIFL RELISNASDA
60 70 80 90 100
LDKIRYESLT DPSKLDSGKE LKIDIIPNPQ ERTLTLVDTG IGMTKADLIN
110 120 130 140 150
NLGTIAKSGT KAFMEALQAG ADISMIGQFG VGFYSAYLVA EKVVVITKHN
160 170 180 190 200
DDEQYAWESS AGGSFTVRAD HGEPIGRGTK VILHLKEDQT EYLEERRVKE
210 220 230 240 250
VVKKHSQFIG YPITLYLEKE REKEISDDEA EEEKGEKEEE DKDDEEKPKI
260 270 280 290 300
EDVGSDEEDD SGKDKKKKTK KIKEKYIDQE ELNKTKPIWT RNPDDITQEE
310 320 330 340 350
YGEFYKSLTN DWEDHLAVKH FSVEGQLEFR ALLFIPRRAP FDLFENKKKK
360 370 380 390 400
NNIKLYVRRV FIMDSCDELI PEYLNFIRGV VDSEDLPLNI SREMLQQSKI
410 420 430 440 450
LKVIRKNIVK KCLELFSELA EDKENYKKFY EAFSKNLKLG IHEDSTNRRR
460 470 480 490 500
LSELLRYHTS QSGDEMTSLS EYVSRMKETQ KSIYYITGES KEQVANSAFV
510 520 530 540 550
ERVRKRGFEV VYMTEPIDEY CVQQLKEFDG KSLVSVTKEG LELPEDEEEK
560 570 580 590 600
KKMEESKAKF ENLCKLMKEI LDKKVEKVTI SNRLVSSPCC IVTSTYGWTA
610 620 630 640 650
NMERIMKAQA LRDNSTMGYM MAKKHLEINP DHPIVETLRQ KAEADKNDKA
660 670 680 690 700
VKDLVVLLFE TALLSSGFSL EDPQTHSNRI YRMIKLGLGI DEDEVAAEEP
710 720
NAAVPDEIPP LEGDEDASRM EEVD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471081 Genomic DNA Translation: EAX04258.1 CH471081 Genomic DNA Translation: EAX04260.1 |
RefSeqi | NP_001258898.1, NM_001271969.1 NP_001258899.1, NM_001271970.1 NP_031381.2, NM_007355.3 |
Genome annotation databases
GeneIDi | 3326 |
KEGGi | hsa:3326 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471081 Genomic DNA Translation: EAX04258.1 CH471081 Genomic DNA Translation: EAX04260.1 |
RefSeqi | NP_001258898.1, NM_001271969.1 NP_001258899.1, NM_001271970.1 NP_031381.2, NM_007355.3 |
3D structure databases
SMRi | A0A024RD80 |
ModBasei | Search... |
Proteomic databases
PRIDEi | A0A024RD80 |
Genome annotation databases
GeneIDi | 3326 |
KEGGi | hsa:3326 |
Organism-specific databases
CTDi | 3326 |
Phylogenomic databases
eggNOGi | KOG0019 Eukaryota KOG0020 Eukaryota COG0326 LUCA |
KOi | K04079 |
OMAi | RTDHGEP |
OrthoDBi | 924636at2759 |
Miscellaneous databases
ChiTaRSi | HSP90AB1 human |
GenomeRNAii | 3326 |
Gene expression databases
Bgeei | ENSG00000096384 Expressed in 240 organ(s), highest expression level in hypothalamus |
ExpressionAtlasi | A0A024RD80 baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505 HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594 HATPase_C IPR036890 HATPase_C_sf IPR019805 Heat_shock_protein_90_CS IPR037196 HSP90_C IPR001404 Hsp90_fam IPR020575 Hsp90_N IPR020568 Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528 PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518 HATPase_c, 1 hit PF00183 HSP90, 1 hit |
PIRSFi | PIRSF002583 Hsp90, 1 hit |
PRINTSi | PR00775 HEATSHOCK90 |
SMARTi | View protein in SMART SM00387 HATPase_c, 1 hit |
SUPFAMi | SSF110942 SSF110942, 1 hit SSF54211 SSF54211, 1 hit SSF55874 SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298 HSP90, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RD80_HUMAN | |
Accessioni | A0A024RD80Primary (citable) accession number: A0A024RD80 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | October 16, 2019 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |