UniProtKB - A0A024RD47 (A0A024RD47_HUMAN)
Protein
Submitted name:
Nuclear receptor co-repressor 1, isoform CRA_a
Gene
NCOR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-bindingARBA annotation, ReceptorImported |
Names & Taxonomyi
Protein namesi | Submitted name: Nuclear receptor co-repressor 1, isoform CRA_aImported |
Gene namesi | Name:NCOR1Imported ORF Names:hCG_1999320Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000141027.20 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000141027, Expressed in corpus callosum and 238 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 435 – 486 | SANTInterPro annotationAdd BLAST | 52 | |
Domaini | 623 – 674 | SANTInterPro annotationAdd BLAST | 52 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 177 | DisorderedSequence analysisAdd BLAST | 177 | |
Regioni | 206 – 231 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 497 – 632 | DisorderedSequence analysisAdd BLAST | 136 | |
Regioni | 677 – 915 | DisorderedSequence analysisAdd BLAST | 239 | |
Regioni | 1022 – 1046 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 1184 – 1204 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1440 – 1459 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 1488 – 1554 | DisorderedSequence analysisAdd BLAST | 67 | |
Regioni | 1690 – 1759 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 1884 – 1922 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1943 – 1969 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 2006 – 2041 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 2067 – 2155 | DisorderedSequence analysisAdd BLAST | 89 | |
Regioni | 2287 – 2440 | DisorderedSequence analysisAdd BLAST | 154 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 308 – 328 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 39 | PolarSequence analysisAdd BLAST | 39 | |
Compositional biasi | 47 – 69 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 100 – 115 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 162 – 177 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 504 – 570 | PolyampholyteSequence analysisAdd BLAST | 67 | |
Compositional biasi | 605 – 620 | Pro-richSequence analysisAdd BLAST | 16 | |
Compositional biasi | 677 – 698 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 712 – 726 | AcidicSequence analysisAdd BLAST | 15 | |
Compositional biasi | 736 – 795 | PolarSequence analysisAdd BLAST | 60 | |
Compositional biasi | 823 – 859 | PolyampholyteSequence analysisAdd BLAST | 37 | |
Compositional biasi | 867 – 884 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 1488 – 1529 | PolarSequence analysisAdd BLAST | 42 | |
Compositional biasi | 1709 – 1732 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1907 – 1922 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1953 – 1967 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2020 – 2040 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 2067 – 2116 | PolarSequence analysisAdd BLAST | 50 | |
Compositional biasi | 2128 – 2142 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2347 – 2361 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 2371 – 2416 | PolarSequence analysisAdd BLAST | 46 |
Sequence similaritiesi
Belongs to the N-CoR nuclear receptor corepressors family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
OMAi | PNREWEE |
OrthoDBi | 12227at2759 |
Family and domain databases
CDDi | cd00167, SANT, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR031557, N-CoR_GPS2_interact IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF15784, GPS2_interact, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51293, SANT, 2 hits |
i Sequence
Sequence statusi: Complete.
A0A024RD47-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV
60 70 80 90 100
SQASQLLQQQ QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD
110 120 130 140 150
HDSLESKRPR LEQVSDSHFQ RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG
160 170 180 190 200
GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE LIQSMDRVDR EIAKVEQQIL
210 220 230 240 250
KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY DENRKKAEEA
260 270 280 290 300
HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR
310 320 330 340 350
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR
360 370 380 390 400
KQREQQERFQ RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL
410 420 430 440 450
SVIPPMMFDA EQRRVKFINM NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD
460 470 480 490 500
KFIQHPKNFG LIASYLERKS VPDCVLYYYL TKKNENYKAL VRRNYGKRRG
510 520 530 540 550
RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE KEDSKENTKE
560 570 580 590 600
KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA
610 620 630 640 650
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI
660 670 680 690 700
AKMVGTKSEA QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE
710 720 730 740 750
SVASTVSAQE DEDIEASNEE ENPEDSEVEA VKPSEDSPEN ATSRGNTEPA
760 770 780 790 800
VELEPTTETA PSTSPSLAVP STKPAEDESV ETQVNDSISA ETAEQMDVDQ
810 820 830 840 850
QEHSAEEGSV CDPPPATKAD SVDVEVRVPE NHASKVEGDN TKERDLDRAS
860 870 880 890 900
EKVEPRDEDL VVAQQINAQR PEPQSDNDSS ATCSADEDVD GEPERQRMFP
910 920 930 940 950
MDSKPSLLNP TGSILVSSPL KPNPLDLPQL QHRAAVIPPM VSCTPCNIPI
960 970 980 990 1000
GTPVSGYALY QRHIKAMHES ALLEEQRQRQ EQIDLECRSS TSPCGTSKSP
1010 1020 1030 1040 1050
NREWEVLQPA PHQVITNLPE GVRLPTTRPT RPPPPLIPSS KTTVASEKPS
1060 1070 1080 1090 1100
FIMGGSISQG TPGTYLTSHN QASYTQETPK PSVGSISLGL PRQQESAKSA
1110 1120 1130 1140 1150
TLPYIKQEEF SPRSQNSQPE GLLVRAQHEG VVRGTAGAIQ EGSITRGTPT
1160 1170 1180 1190 1200
SKISVESIPS LRGSITQGTP ALPQTGIPTE ALVKGSISRM PIEDSSPEKG
1210 1220 1230 1240 1250
REEAASKGHV IYEGKSGHIL SYDNIKNARE GTRSPRTAHE ISLKRSYESV
1260 1270 1280 1290 1300
EGNIKQGMSM RESPVSAPLE GLICRALPRG SPHSDLKERT VLSGSIMQGT
1310 1320 1330 1340 1350
PRATTESFED GLKYPKQIKR ESPPIRAFEG AITKGKPYDG ITTIKEMGRS
1360 1370 1380 1390 1400
IHEIPRQDIL TQESRKTPEV VQSTRPIIEG SISQGTPIKF DNNSGQSAIK
1410 1420 1430 1440 1450
HNVKSLITGP SKLSRGMPPL EIVPENIKVV ERGKYEDVKA GETVRSRHTS
1460 1470 1480 1490 1500
VVSSGPSVLR STLHEAPKAQ LSPGIYDDTS ARRTPVSYQN TMSRGSPMMN
1510 1520 1530 1540 1550
RTSDVTISSN KSTNHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH
1560 1570 1580 1590 1600
HRGSTAGEVY RSHLPTHLDP AMPFHRALDP AAAAYLFQRQ LSPTPGYPSQ
1610 1620 1630 1640 1650
YQLYAMENTR QTILNDYITS QQMQVNLRPD VARGLSPREQ PLGLPYPATR
1660 1670 1680 1690 1700
GIIDLTNMPP TILVPHPGGT STPPMDRITY IPGTQITFPP RPYNSASMSP
1710 1720 1730 1740 1750
GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP GSEQPGRPGS
1760 1770 1780 1790 1800
HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA
1810 1820 1830 1840 1850
GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE
1860 1870 1880 1890 1900
ENLRSRSAAV SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY
1910 1920 1930 1940 1950
SEAGKDKGPP PKSRYEEELR TRGKTTITAA NFIDVIITRQ IASDKDARER
1960 1970 1980 1990 2000
GSQSSDSSSS LSSHRYETPS DAIEVISPAS SPAPPQEKLQ TYQPEVVKAN
2010 2020 2030 2040 2050
QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG QVPRTHRLIT
2060 2070 2080 2090 2100
LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR
2110 2120 2130 2140 2150
YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI
2160 2170 2180 2190 2200
SPPQVPVVHE KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN
2210 2220 2230 2240 2250
TSPMVKSKKQ EIFRKLNSSG GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR
2260 2270 2280 2290 2300
GHSFADPASN LGLEDIIRKA LMGSFDDKVE DHGVVMSQPM GVVPGTANTS
2310 2320 2330 2340 2350
VVTSGETRRE EGDPSPHSGG VCKPKLISKS NSRKSKSPIP GQGYLGTERP
2360 2370 2380 2390 2400
SSVSSVHSEG DYHRQTPGWA WEDRPSSTGS TQFPYNPLTM RMLSSTPPTP
2410 2420 2430 2440
IACAPSAVNQ AAPHQQNRIW EREPAPLLSA QYETLSDSDD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471222 Genomic DNA Translation: EAX04492.1 CH471222 Genomic DNA Translation: EAX04493.1 |
RefSeqi | NP_006302.2, NM_006311.3 |
Genome annotation databases
GeneIDi | 9611 |
KEGGi | hsa:9611 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471222 Genomic DNA Translation: EAX04492.1 CH471222 Genomic DNA Translation: EAX04493.1 |
RefSeqi | NP_006302.2, NM_006311.3 |
3D structure databases
SMRi | A0A024RD47 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024RD47 |
Protocols and materials databases
Antibodypediai | 13188, 397 antibodies |
Genome annotation databases
GeneIDi | 9611 |
KEGGi | hsa:9611 |
Organism-specific databases
CTDi | 9611 |
EuPathDBi | HostDB:ENSG00000141027.20 |
Phylogenomic databases
OMAi | PNREWEE |
OrthoDBi | 12227at2759 |
Miscellaneous databases
BioGRID-ORCSi | 9611, 42 hits in 877 CRISPR screens |
ChiTaRSi | NCOR1, human |
GenomeRNAii | 9611 |
Gene expression databases
Bgeei | ENSG00000141027, Expressed in corpus callosum and 238 other tissues |
Family and domain databases
CDDi | cd00167, SANT, 2 hits |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR031557, N-CoR_GPS2_interact IPR001005, SANT/Myb IPR017884, SANT_dom |
Pfami | View protein in Pfam PF15784, GPS2_interact, 1 hit PF00249, Myb_DNA-binding, 1 hit |
SMARTi | View protein in SMART SM00717, SANT, 2 hits |
SUPFAMi | SSF46689, SSF46689, 2 hits |
PROSITEi | View protein in PROSITE PS51293, SANT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RD47_HUMAN | |
Accessioni | A0A024RD47Primary (citable) accession number: A0A024RD47 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |