UniProtKB - A0A024RCN9 (A0A024RCN9_HUMAN)
Protein
Submitted name:
EHMT2
Gene
EHMT2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- histone-lysine N-methyltransferase activity Source: InterPro
- p53 binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | MethyltransferaseImported, Transferase |
Names & Taxonomyi
Protein namesi | Submitted name: EHMT2ImportedSubmitted name: Euchromatic histone-lysine N-methyltransferase 2, isoform CRA_cImported |
Gene namesi | Name:EHMT2Imported ORF Names:hCG_1811586Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000204371.11 |
Subcellular locationi
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000204371, Expressed in subventricular zone (inner) (primate) and 220 other tissues |
Interactioni
GO - Molecular functioni
- p53 binding Source: InterPro
Chemistry databases
BindingDBi | A0A024RCN9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 654 – 887 | ANK_REP_REGIONInterPro annotationAdd BLAST | 234 | |
Repeati | 684 – 716 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 717 – 749 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 750 – 774 | ANKPROSITE-ProRule annotationAdd BLAST | 25 | |
Repeati | 784 – 816 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 850 – 882 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 972 – 1035 | Pre-SETInterPro annotationAdd BLAST | 64 | |
Domaini | 1038 – 1155 | SETInterPro annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 262 | DisorderedSequence analysisAdd BLAST | 262 | |
Regioni | 280 – 386 | DisorderedSequence analysisAdd BLAST | 107 | |
Regioni | 548 – 608 | DisorderedSequence analysisAdd BLAST | 61 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 114 – 128 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 202 – 226 | PolyampholyteSequence analysisAdd BLAST | 25 | |
Compositional biasi | 280 – 295 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 296 – 328 | AcidicSequence analysisAdd BLAST | 33 | |
Compositional biasi | 338 – 365 | BasicSequence analysisAdd BLAST | 28 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotationPhylogenomic databases
OrthoDBi | 753093at2759 |
PhylomeDBi | A0A024RCN9 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR043550, EHMT1/EHMT2 IPR038034, EHMT2 IPR007728, Pre-SET_dom IPR001214, SET_dom |
PANTHERi | PTHR46307, PTHR46307, 1 hit PTHR46307:SF1, PTHR46307:SF1, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00468, PreSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS50867, PRE_SET, 1 hit PS50280, SET, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RCN9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAGAAAA AAAEGEAPAE MGALLLEKET RGATERVHGS LGDTPRSEET
60 70 80 90 100
LPKATPDSLE PAGPSSPASV TVTVGDEGAD TPVGATPLIG DESENLEGDG
110 120 130 140 150
DLRGGRILLG HATKSFPSSP SKGGSCPSRA KMSMTGAGKS PPSVQSLAMR
160 170 180 190 200
LLSMPGAQGA AAAGSEPPPA TTSPEGQPKV HRARKTMSKP GNGQPPVPEK
210 220 230 240 250
RPPEIQHFRM SDDVHSLGKV TSDLAKRRKL NSGGGLSEEL GSARRSGEVT
260 270 280 290 300
LTKGDPGSLE EWETVVGDDF SLYYDSYSVD ERVDSDSKSE VEALTEQLSE
310 320 330 340 350
EEEEEEEEEE EEEEEEEEEE EEEDEESGNQ SDRSGSSGRR KAKKKWRKDS
360 370 380 390 400
PWVKPSRKRR KREPPRAKEP RGVNGVGSSG PSEYMEVPLG SLELPSEGTL
410 420 430 440 450
SPNHAGVSND TSSLETERGF EELPLCSCRM EAPKIDRISE RAGHKCMATE
460 470 480 490 500
SVDGELSGCN AAILKRETMR PSSRVALMVL CETHRARMVK HHCCPGCGYF
510 520 530 540 550
CTAGTFLECH PDFRVAHRFH KACVSQLNGM VFCPHCGEDA SEAQEVTIPR
560 570 580 590 600
GDGVTPPAGT AAPAPPPLSQ DVPGRADTSQ PSARMRGHGE PRRPPCDPLA
610 620 630 640 650
DTIDSSGPSL TLPNGGCLSA VGLPLGPGRE ALEKALVIQE SERRKKLRFH
660 670 680 690 700
PRQLYLSVKQ GELQKVILML LDNLDPNFQS DQQSKRTPLH AAAQKGSVEI
710 720 730 740 750
CHVLLQAGAN INAVDKQQRT PLMEAVVNNH LEVARYMVQR GGCVYSKEED
760 770 780 790 800
GSTCLHHAAK IGNLEMVSLL LSTGQVDVNA QDSGGWTPII WAAEHKHIEV
810 820 830 840 850
IRMLLTRGAD VTLTDNEENI CLHWASFTGS AAIAEVLLNA RCDLHAVNYH
860 870 880 890 900
GDTPLHIAAR ESYHDCVLLF LSRGANPELR NKEGDTAWDL TPERSDVWFA
910 920 930 940 950
LQLNRKLRLG VGNRAIRTEK IICRDVARGY ENVPIPCVNG VDGEPCPEDY
960 970 980 990 1000
KYISENCETS TMNIDRNITH LQHCTCVDDC SSSNCLCGQL SIRCWYDKDG
1010 1020 1030 1040 1050
RLLQEFNKIE PPLIFECNQA CSCWRNCKNR VVQSGIKVRL QLYRTAKMGW
1060 1070 1080 1090 1100
GVRALQTIPQ GTFICEYVGE LISDAEADVR EDDSYLFDLD NKDGEVYCID
1110 1120 1130 1140 1150
ARYYGNISRF INHLCDPNII PVRVFMLHQD LRFPRIAFFS SRDIRTGEEL
1160 1170 1180 1190 1200
GFDYGDRFWD IKSKYFTCQC GSEKCKHSAE AIALEQSRLA RLDPHPELLP
1210
ELGSLPPVNT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KY500322 Genomic DNA Translation: AQY76810.1 KY500323 Genomic DNA Translation: AQY76811.1 CH471081 Genomic DNA Translation: EAX03544.1 |
RefSeqi | NP_006700.3, NM_006709.4 |
Genome annotation databases
GeneIDi | 10919 |
KEGGi | hsa:10919 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KY500322 Genomic DNA Translation: AQY76810.1 KY500323 Genomic DNA Translation: AQY76811.1 CH471081 Genomic DNA Translation: EAX03544.1 |
RefSeqi | NP_006700.3, NM_006709.4 |
3D structure databases
SMRi | A0A024RCN9 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024RCN9 |
Protocols and materials databases
Antibodypediai | 27888, 350 antibodies |
Genome annotation databases
GeneIDi | 10919 |
KEGGi | hsa:10919 |
Organism-specific databases
CTDi | 10919 |
EuPathDBi | HostDB:ENSG00000204371.11 |
Phylogenomic databases
OrthoDBi | 753093at2759 |
PhylomeDBi | A0A024RCN9 |
Miscellaneous databases
BioGRID-ORCSi | 10919, 75 hits in 851 CRISPR screens |
ChiTaRSi | EHMT2, human |
GenomeRNAii | 10919 |
Gene expression databases
Bgeei | ENSG00000204371, Expressed in subventricular zone (inner) (primate) and 220 other tissues |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR043550, EHMT1/EHMT2 IPR038034, EHMT2 IPR007728, Pre-SET_dom IPR001214, SET_dom |
PANTHERi | PTHR46307, PTHR46307, 1 hit PTHR46307:SF1, PTHR46307:SF1, 1 hit |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF05033, Pre-SET, 1 hit PF00856, SET, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00468, PreSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS50867, PRE_SET, 1 hit PS50280, SET, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RCN9_HUMAN | |
Accessioni | A0A024RCN9Primary (citable) accession number: A0A024RCN9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |