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UniProtKB - A0A024RC04 (A0A024RC04_HUMAN)

Entry version 48 (10 Feb 2021)
Sequence version 1 (09 Jul 2014)
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Protein
Submitted name:

Zinc finger protein, X-linked, isoform CRA_a

Gene

ZFX

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein, X-linked, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZFXImported
ORF Names:hCG_18656Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000005889.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000005889, Expressed in kidney and 225 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A024RC04, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini425 – 455C2H2-typeInterPro annotationAdd BLAST31
Domaini456 – 478C2H2-typeInterPro annotationAdd BLAST23
Domaini488 – 515C2H2-typeInterPro annotationAdd BLAST28
Domaini519 – 547C2H2-typeInterPro annotationAdd BLAST29
Domaini548 – 575C2H2-typeInterPro annotationAdd BLAST28
Domaini576 – 604C2H2-typeInterPro annotationAdd BLAST29
Domaini605 – 632C2H2-typeInterPro annotationAdd BLAST28
Domaini633 – 661C2H2-typeInterPro annotationAdd BLAST29
Domaini662 – 689C2H2-typeInterPro annotationAdd BLAST28
Domaini690 – 718C2H2-typeInterPro annotationAdd BLAST29
Domaini719 – 746C2H2-typeInterPro annotationAdd BLAST28
Domaini747 – 775C2H2-typeInterPro annotationAdd BLAST29
Domaini776 – 803C2H2-typeInterPro annotationAdd BLAST28

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00096, zf-C2H2, 7 hits
PF04704, Zfx_Zfy_act, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00355, ZnF_C2H2, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A024RC04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDGLELQQ EPNSFFDATG ADGTHMDGDQ IVVEVQETVF VSDVVDSDIT 
        60         70         80         90        100
VHNFVPDDPD SVVIQDVIED VVIEDVQCPD IMEEADVSET VIIPEQVLDS 
       110        120        130        140        150
DVTEEVSLAH CTVPDDVLAS DITSASMSMP EHVLTGDSIH VSDVGHVGHV 
       160        170        180        190        200
GHVEHVVHDS VVEAEIVTDP LTTDVVSEEV LVADCASEAV IDANGIPVDQ 
       210        220        230        240        250
QDDDKGNCED YLMISLDDAG KIEHDGSSGM TMDTESEIDP CKVDGTCPEV 
       260        270        280        290        300
IKVYIFKADP GEDDLGGTVD IVESEPENDH GVELLDQNSS IRVPREKMVY 
       310        320        330        340        350
MTVNDSQPED EDLNVAEIAD EVYMEVIVGE EDAAAAAAAA AVHEQQMDDN 
       360        370        380        390        400
EIKTFMPIAW AAAYGNNSDG IENRNGTASA LLHIDESAGL GRLAKQKPKK 
       410        420        430        440        450
RRRPDSRQYQ TAIIIGPDGH PLTVYPCMIC GKKFKSRGFL KRHMKNHPEH 
       460        470        480        490        500
LAKKKYRCTD CDYTTNKKIS LHNHLESHKL TSKAEKAIEC DECGKHFSHA 
       510        520        530        540        550
GALFTHKMVH KEKGANKMHK CKFCEYETAE QGLLNRHLLA VHSKNFPHIC 
       560        570        580        590        600
VECGKGFRHP SELKKHMRIH TGEKPYQCQY CEYRSADSSN LKTHVKTKHS 
       610        620        630        640        650
KEMPFKCDIC LLTFSDTKEV QQHALIHQES KTHQCLHCDH KSSNSSDLKR 
       660        670        680        690        700
HIISVHTKDY PHKCDMCDKG FHRPSELKKH VAAHKGKKMH QCRHCDFKIA 
       710        720        730        740        750
DPFVLSRHIL SVHTKDLPFR CKRCRKGFRQ QSELKKHMKT HSGRKVYQCE 
       760        770        780        790        800
YCEYSTTDAS GFKRHVISIH TKDYPHRCEY CKKGFRRPSE KNQHIMRHHK 

EVGLP
Length:805
Mass (Da):90,522
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB074079D1762A0AD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471074 Genomic DNA Translation: EAW99013.1
CH471074 Genomic DNA Translation: EAW99014.1
CH471074 Genomic DNA Translation: EAW99015.1

NCBI Reference Sequences

More...RefSeqi		NP_001171555.1, NM_001178084.1
NP_001171556.1, NM_001178085.1
NP_003401.2, NM_003410.3
XP_005274648.1, XM_005274591.4
XP_005274649.1, XM_005274592.3
XP_011543881.1, XM_011545579.1
XP_011543883.1, XM_011545581.2
XP_016885283.1, XM_017029794.1
XP_016885284.1, XM_017029795.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7543

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471074 Genomic DNA Translation: EAW99013.1
CH471074 Genomic DNA Translation: EAW99014.1
CH471074 Genomic DNA Translation: EAW99015.1
RefSeqiNP_001171555.1, NM_001178084.1
NP_001171556.1, NM_001178085.1
NP_003401.2, NM_003410.3
XP_005274648.1, XM_005274591.4
XP_005274649.1, XM_005274592.3
XP_011543881.1, XM_011545579.1
XP_011543883.1, XM_011545581.2
XP_016885283.1, XM_017029794.1
XP_016885284.1, XM_017029795.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		577, 169 antibodies

Genome annotation databases

GeneIDi7543
KEGGihsa:7543

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7543
VEuPathDBiHostDB:ENSG00000005889.15

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7543, 51 hits in 523 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZFX, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7543

Gene expression databases

BgeeiENSG00000005889, Expressed in kidney and 225 other tissues
ExpressionAtlasiA0A024RC04, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR006794, Transcrp_activ_Zfx/Zfy-dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 7 hits
PF04704, Zfx_Zfy_act, 1 hit
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 13 hits
SUPFAMiSSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 7 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A024RC04_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A024RC04
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 9, 2014
Last sequence update: July 9, 2014
Last modified: February 10, 2021
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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