UniProtKB - A0A024RBI1 (A0A024RBI1_HUMAN)
Protein
Submitted name:
D-amino-acid oxidase isoform 1
Gene
DAO
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
FADUniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 53 | SubstrateUniRule annotation | 1 | |
Binding sitei | 164 | FAD; via amide nitrogen and carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 182 | FADUniRule annotation | 1 | |
Binding sitei | 217 | SubstrateUniRule annotation | 1 | |
Binding sitei | 228 | SubstrateUniRule annotation | 1 | |
Binding sitei | 283 | SubstrateUniRule annotation | 1 | |
Binding sitei | 313 | SubstrateUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 37 – 38 | FADUniRule annotation | 2 | |
Nucleotide bindingi | 44 – 45 | FADUniRule annotation | 2 | |
Nucleotide bindingi | 49 – 51 | FADUniRule annotation | 3 | |
Nucleotide bindingi | 312 – 317 | FADUniRule annotation | 6 |
GO - Molecular functioni
- D-amino-acid oxidase activity Source: InterPro
- FAD binding Source: InterPro
GO - Biological processi
- D-amino acid metabolic process Source: InterPro
Keywordsi
Ligand | FADUniRule annotation, Flavoprotein |
Names & Taxonomyi
Protein namesi | Submitted name: D-amino-acid oxidase isoform 1ImportedSubmitted name: D-amino-acid oxidase, isoform CRA_cImported |
Gene namesi | Name:DAOImported ORF Names:hCG_14880Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000110887.7 |
Subcellular locationi
Peroxisome
- Peroxisome ARBA annotation
Peroxisome
- peroxisome Source: UniProtKB-SubCell
Keywords - Cellular componenti
PeroxisomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000110887, Expressed in liver and 110 other tissues |
ExpressionAtlasi | A0A024RBI1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 328 | DAOInterPro annotationAdd BLAST | 327 |
Sequence similaritiesi
Belongs to the DAMOX/DASOX family.ARBA annotation
Phylogenomic databases
OMAi | WPYRIEP |
OrthoDBi | 1363414at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR006181, D-amino_acid_oxidase_CS IPR023209, DAO IPR006076, FAD-dep_OxRdtase |
PANTHERi | PTHR11530, PTHR11530, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit |
PIRSFi | PIRSF000189, D-aa_oxidase, 1 hit |
PROSITEi | View protein in PROSITE PS00677, DAO, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RBI1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRVVVIGAGV IGLSTALCIH ERYHSVLQPL DIKVYADRFT PLTTTDVAAG
60 70 80 90 100
LWQPYLSDPN NPQEADWSQQ TFDYLLSHVH SPNAENLGLF LISGYNLFHE
110 120 130 140 150
AIPDPSWKDT VLGFRKLTPR ELDMFPDYGY GWFHTSLILE GKNYLQWLTE
160 170 180 190 200
RLTERGVKFF QRKVESFEEV AREGADVIVN CTGVWAGALQ RDPLLQPGRG
210 220 230 240 250
QIMKVDAPWM KHFILTHDPE RGIYNSPYII PGTQTVTLGG IFQLGNWSEL
260 270 280 290 300
NNIQDHNTIW EGCCRLEPTL KNARIIGERT GFRPVRPQIR LEREQLRTGP
310 320 330 340
SNTEVIHNYG HGGYGLTIHW GCALEAAKLF GRILEEKKLS RMPPSHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178015 mRNA Translation: ALQ33473.1 CH471054 Genomic DNA Translation: EAW97838.1 |
RefSeqi | NP_001908.3, NM_001917.4 XP_011536306.1, XM_011538004.2 XP_011536307.1, XM_011538005.2 |
Genome annotation databases
GeneIDi | 1610 |
KEGGi | hsa:1610 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178015 mRNA Translation: ALQ33473.1 CH471054 Genomic DNA Translation: EAW97838.1 |
RefSeqi | NP_001908.3, NM_001917.4 XP_011536306.1, XM_011538004.2 XP_011536307.1, XM_011538005.2 |
3D structure databases
SMRi | A0A024RBI1 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024RBI1 |
Protocols and materials databases
Antibodypediai | 30788, 289 antibodies |
DNASUi | 1610 |
Genome annotation databases
GeneIDi | 1610 |
KEGGi | hsa:1610 |
Organism-specific databases
CTDi | 1610 |
VEuPathDBi | HostDB:ENSG00000110887.7 |
Phylogenomic databases
OMAi | WPYRIEP |
OrthoDBi | 1363414at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1610, 7 hits in 986 CRISPR screens |
ChiTaRSi | DAO, human |
GenomeRNAii | 1610 |
Gene expression databases
Bgeei | ENSG00000110887, Expressed in liver and 110 other tissues |
ExpressionAtlasi | A0A024RBI1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006181, D-amino_acid_oxidase_CS IPR023209, DAO IPR006076, FAD-dep_OxRdtase |
PANTHERi | PTHR11530, PTHR11530, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit |
PIRSFi | PIRSF000189, D-aa_oxidase, 1 hit |
PROSITEi | View protein in PROSITE PS00677, DAO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RBI1_HUMAN | |
Accessioni | A0A024RBI1Primary (citable) accession number: A0A024RBI1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |