UniProtKB - A0A024RBC5 (A0A024RBC5_HUMAN)
Protein
N-acetylglucosamine-6-sulfatase
Gene
GNS
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.UniRule annotation EC:3.1.6.14
Cofactori
Ca2+UniRule annotationARBA annotation
GO - Molecular functioni
- metal ion binding Source: UniProtKB-UniRule
- N-acetylglucosamine-6-sulfatase activity Source: UniProtKB-UniRule
GO - Biological processi
- glycosaminoglycan metabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Ligand | CalciumUniRule annotation, Metal-bindingUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: N-acetylglucosamine-6-sulfataseUniRule annotation (EC:3.1.6.14UniRule annotation)Alternative name(s): Glucosamine-6-sulfataseUniRule annotation |
Gene namesi | Name:GNSImported ORF Names:hCG_1640559Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000135677.10 |
Subcellular locationi
Keywords - Cellular componenti
LysosomeUniRule annotationPTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 91 | 3-oxoalanine (Cys)UniRule annotation | 1 |
Post-translational modificationi
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.UniRule annotation
Expressioni
Gene expression databases
Bgeei | ENSG00000135677, Expressed in metanephros and 252 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 384 | SulfataseInterPro annotationAdd BLAST | 338 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 1273622at2759 |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR012251, GlcNAc_6-SO4ase IPR015981, GlcNAc_6-SO4ase_met IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
PANTHERi | PTHR43108:SF5, PTHR43108:SF5, 1 hit |
Pfami | View protein in Pfam PF00884, Sulfatase, 1 hit |
PIRSFi | PIRSF036666, G6S, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit PS00149, SULFATASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RBC5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLPLAPGR LRRGSPRHLP SCSPALLLLV LGGCLGVFGV AAGTRRPNVV
60 70 80 90 100
LLLTDDQDEV LGGMTPLKKT KALIGEMGMT FSSAYVPSAL CCPSRASILT
110 120 130 140 150
GKYPHNHHVV NNTLEGNCSS KSWQKIQEPN TFPAILRSMC GYQTFFAGKY
160 170 180 190 200
LNEYGAPDAG GLEHVPLGWS YWYALEKNSK YYNYTLSING KARKHGENYS
210 220 230 240 250
VDYLTDVLAN VSLDFLDYKS NFEPFFMMIA TPAPHSPWTA APQYQKAFQN
260 270 280 290 300
VFAPRNKNFN IHGTNKHWLI RQAKTPMTNS SIQFLDNAFR KRWQTLLSVD
310 320 330 340 350
DLVEKLVKRL EFTGELNNTY IFYTSDNGYH TGQFSLPIDK RQLYEFDIKV
360 370 380 390 400
PLLVRGPGIK PNQTSKMLVA NIDLGPTILD IAGYDLNKTQ MDGMSLLPIL
410 420 430 440 450
RGASNLTWRS DVLVEYQGEG RNVTDPTCPS LSPGVSQCFP DCVCEDAYNN
460 470 480 490 500
TYACVRTMSA LWNLQYCEFD DQEVFVEVYN LTADPDQITN IAKTIDPELL
510 520 530 540 550
GKMNYRLMML QSCSGPTCRT PGVFDPGYRF DPRLMFSNRG SVRTRRFSKH
LL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178097 mRNA Translation: ALQ33555.1 CH471054 Genomic DNA Translation: EAW97138.1 CH471054 Genomic DNA Translation: EAW97140.1 |
RefSeqi | NP_002067.1, NM_002076.3 |
Genome annotation databases
GeneIDi | 2799 |
KEGGi | hsa:2799 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KU178097 mRNA Translation: ALQ33555.1 CH471054 Genomic DNA Translation: EAW97138.1 CH471054 Genomic DNA Translation: EAW97140.1 |
RefSeqi | NP_002067.1, NM_002076.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 2462, 228 antibodies |
Genome annotation databases
GeneIDi | 2799 |
KEGGi | hsa:2799 |
Organism-specific databases
CTDi | 2799 |
EuPathDBi | HostDB:ENSG00000135677.10 |
Phylogenomic databases
OrthoDBi | 1273622at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2799, 9 hits in 844 CRISPR screens |
ChiTaRSi | GNS, human |
GenomeRNAii | 2799 |
Gene expression databases
Bgeei | ENSG00000135677, Expressed in metanephros and 252 other tissues |
Family and domain databases
Gene3Di | 3.40.720.10, 1 hit |
InterProi | View protein in InterPro IPR017850, Alkaline_phosphatase_core_sf IPR012251, GlcNAc_6-SO4ase IPR015981, GlcNAc_6-SO4ase_met IPR024607, Sulfatase_CS IPR000917, Sulfatase_N |
PANTHERi | PTHR43108:SF5, PTHR43108:SF5, 1 hit |
Pfami | View protein in Pfam PF00884, Sulfatase, 1 hit |
PIRSFi | PIRSF036666, G6S, 1 hit |
SUPFAMi | SSF53649, SSF53649, 1 hit |
PROSITEi | View protein in PROSITE PS00523, SULFATASE_1, 1 hit PS00149, SULFATASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RBC5_HUMAN | |
Accessioni | A0A024RBC5Primary (citable) accession number: A0A024RBC5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | December 2, 2020 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |