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UniProtKB - A0A024RB77 (A0A024RB77_HUMAN)
Protein
Submitted name:
Cyclin-dependent kinase 2, isoform CRA_b
Gene
CDK2
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- cyclin binding Source: Ensembl
- cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
- magnesium ion binding Source: Ensembl
GO - Biological processi
- G1/S transition of mitotic cell cycle Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of DNA-dependent DNA replication initiation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- potassium ion transport Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Cyclin-dependent kinase 2, isoform CRA_bImported |
Gene namesi | Name:CDK2Imported ORF Names:hCG_24992Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000123374 |
Subcellular locationi
Cytoskeleton
- centrosome Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- chromosome, telomeric region Source: Ensembl
- condensed chromosome Source: Ensembl
- cyclin A1-CDK2 complex Source: Ensembl
- cyclin A2-CDK2 complex Source: Ensembl
- cyclin E1-CDK2 complex Source: Ensembl
- cyclin E2-CDK2 complex Source: Ensembl
- transcription regulator complex Source: Ensembl
- X chromosome Source: Ensembl
- Y chromosome Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000123374, Expressed in ventricular zone and 215 other tissues |
ExpressionAtlasi | A0A024RB77, baseline and differential |
Interactioni
GO - Molecular functioni
- cyclin binding Source: Ensembl
Chemistry databases
BindingDBi | A0A024RB77 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 286 | Protein kinaseInterPro annotationAdd BLAST | 283 |
Sequence similaritiesi
Belongs to the protein kinase superfamily.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_000288_181_1_1 |
OMAi | HKEKCIY |
PhylomeDBi | A0A024RB77 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RB77-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR
60 70 80 90 100
EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP
110 120 130 140 150
LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINTEGA IKLADFGLAR
160 170 180 190 200
AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMVTRR
210 220 230 240 250
ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK
260 270 280 290
VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471054 Genomic DNA Translation: EAW96860.1 |
RefSeqi | NP_001789.2, NM_001798.4 |
Genome annotation databases
GeneIDi | 1017 |
KEGGi | hsa:1017 |
MANE-Selecti | ENST00000266970.9; ENSP00000266970.4; NM_001798.5; NP_001789.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471054 Genomic DNA Translation: EAW96860.1 |
RefSeqi | NP_001789.2, NM_001798.4 |
3D structure databases
SMRi | A0A024RB77 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A024RB77 |
Protocols and materials databases
Antibodypediai | 3404, 1711 antibodies from 50 providers |
DNASUi | 1017 |
Genome annotation databases
GeneIDi | 1017 |
KEGGi | hsa:1017 |
MANE-Selecti | ENST00000266970.9; ENSP00000266970.4; NM_001798.5; NP_001789.2 |
Organism-specific databases
CTDi | 1017 |
VEuPathDBi | HostDB:ENSG00000123374 |
Phylogenomic databases
HOGENOMi | CLU_000288_181_1_1 |
OMAi | HKEKCIY |
PhylomeDBi | A0A024RB77 |
Miscellaneous databases
BioGRID-ORCSi | 1017, 535 hits in 1128 CRISPR screens |
ChiTaRSi | CDK2, human |
GenomeRNAii | 1017 |
Gene expression databases
Bgeei | ENSG00000123374, Expressed in ventricular zone and 215 other tissues |
ExpressionAtlasi | A0A024RB77, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RB77_HUMAN | |
Accessioni | A0A024RB77Primary (citable) accession number: A0A024RB77 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | May 25, 2022 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |