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UniProtKB - A0A024RB59 (A0A024RB59_HUMAN)
Protein
Phosphodiesterase
Gene
PDE1B
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
a divalent metal cationUniRule annotationNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 223 | Proton donorUniRule annotation | 1 | |
Metal bindingi | 227 | Divalent metal cation 1UniRule annotation | 1 | |
Metal bindingi | 263 | Divalent metal cation 1UniRule annotation | 1 | |
Metal bindingi | 264 | Divalent metal cation 1UniRule annotation | 1 | |
Metal bindingi | 264 | Divalent metal cation 2UniRule annotation | 1 | |
Binding sitei | 264 | cNMPUniRule annotation | 1 | |
Metal bindingi | 370 | Divalent metal cation 1UniRule annotation | 1 | |
Binding sitei | 370 | cNMPUniRule annotation | 1 | |
Binding sitei | 421 | cNMPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 223 – 227 | cNMPUniRule annotation | 5 |
GO - Molecular functioni
- 3',5'-cyclic-nucleotide phosphodiesterase activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- locomotory behavior Source: Ensembl
- regulation of dopamine metabolic process Source: Ensembl
- regulation of neurotransmitter levels Source: Ensembl
- response to amphetamine Source: Ensembl
- serotonin metabolic process Source: Ensembl
- signal transduction Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:PDE1BImported ORF Names:hCG_21934Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000123360 |
Expressioni
Gene expression databases
Bgeei | ENSG00000123360, Expressed in caudate nucleus and 129 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 146 – 503 | PDEaseInterPro annotationAdd BLAST | 358 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 447 – 474 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 494 – 536 | DisorderedSequence analysisAdd BLAST | 43 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 39 – 59 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 71 – 91 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 450 – 464 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_005940_1_0_1 |
OMAi | PCEEEPR |
OrthoDBi | 904682at2759 |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS IPR013706, PDEase_N |
Pfami | View protein in Pfam PF00233, PDEase_I, 1 hit PF08499, PDEase_I_N, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A024RB59-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELSPRSPPE MLEESDCPSP LELKSAPSKK MWIKLRSLLR YMVKQLENGE
60 70 80 90 100
INIEELKKNL EYTASLLEAV YIDETRQILD TEDELQELRS DAVPSEVRDW
110 120 130 140 150
LASTFTQQAR AKGRRAEEKP KFRSIVHAVQ AGIFVERMFR RTYTSVGPTY
160 170 180 190 200
STAVLNCLKN LDLWCFDVFS LNQAADDHAL RTIVFELLTR HNLISRFKIP
210 220 230 240 250
TVFLMSFLDA LETGYGKYKN PYHNQIHAAD VTQTVHCFLL RTGMVHCLSE
260 270 280 290 300
IELLAIIFAA AIHDYEHTGT TNSFHIQTKS ECAIVYNDRS VLENHHISSV
310 320 330 340 350
FRLMQDDEMN IFINLTKDEF VELRALVIEM VLATDMSCHF QQVKTMKTAL
360 370 380 390 400
QQLERIDKPK ALSLLLHAAD ISHPTKQWLV HSRWTKALME EFFRQGDKEA
410 420 430 440 450
ELGLPFSPLC DRTSTLVAQS QIGFIDFIVE PTFSVLTDVA EKSVQPLADE
460 470 480 490 500
DSKSKNQPSF QWRQPSLDVE VGDPNPDVVS FRSTWVKRIQ ENKQKWKERA
510 520 530
ASGITNQMSI DELSPCEEEA PPSPAEDEHN QNGNLD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471054 Genomic DNA Translation: EAW96788.1 CH471054 Genomic DNA Translation: EAW96789.1 CH471054 Genomic DNA Translation: EAW96791.1 |
RefSeqi | NP_000915.1, NM_000924.3 |
Genome annotation databases
GeneIDi | 5153 |
KEGGi | hsa:5153 |
MANE-Selecti | ENST00000243052.8; ENSP00000243052.3; NM_000924.4; NP_000915.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471054 Genomic DNA Translation: EAW96788.1 CH471054 Genomic DNA Translation: EAW96789.1 CH471054 Genomic DNA Translation: EAW96791.1 |
RefSeqi | NP_000915.1, NM_000924.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 15408, 385 antibodies from 30 providers |
DNASUi | 5153 |
Genome annotation databases
GeneIDi | 5153 |
KEGGi | hsa:5153 |
MANE-Selecti | ENST00000243052.8; ENSP00000243052.3; NM_000924.4; NP_000915.1 |
Organism-specific databases
CTDi | 5153 |
VEuPathDBi | HostDB:ENSG00000123360 |
Phylogenomic databases
HOGENOMi | CLU_005940_1_0_1 |
OMAi | PCEEEPR |
OrthoDBi | 904682at2759 |
Miscellaneous databases
BioGRID-ORCSi | 5153, 12 hits in 1041 CRISPR screens |
GenomeRNAii | 5153 |
Gene expression databases
Bgeei | ENSG00000123360, Expressed in caudate nucleus and 129 other tissues |
Family and domain databases
CDDi | cd00077, HDc, 1 hit |
Gene3Di | 1.10.1300.10, 1 hit |
InterProi | View protein in InterPro IPR003607, HD/PDEase_dom IPR023088, PDEase IPR002073, PDEase_catalytic_dom IPR036971, PDEase_catalytic_dom_sf IPR023174, PDEase_CS IPR013706, PDEase_N |
Pfami | View protein in Pfam PF00233, PDEase_I, 1 hit PF08499, PDEase_I_N, 1 hit |
PRINTSi | PR00387, PDIESTERASE1 |
SMARTi | View protein in SMART SM00471, HDc, 1 hit |
PROSITEi | View protein in PROSITE PS00126, PDEASE_I_1, 1 hit PS51845, PDEASE_I_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A024RB59_HUMAN | |
Accessioni | A0A024RB59Primary (citable) accession number: A0A024RB59 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 9, 2014 |
Last sequence update: | July 9, 2014 | |
Last modified: | January 19, 2022 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |